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What you need to know about CBD and Opiods

The statistics in both the US and in Europe looks bleak with rising opioid-related deaths and rampant opioid addiction. Although medications with opioids in them are effective at treating pain, they have hard-core side effects, and most worryingly, are ridiculously addictive. The staggering rate of addiction to prescription and non prescription medication is a crisis […]

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The statistics in both the US and in Europe looks bleak with rising opioid-related deaths and rampant opioid addiction. Although medications with opioids in them are effective at treating pain, they have hard-core side effects, and most worryingly, are ridiculously addictive. The staggering rate of addiction to prescription and non prescription medication is a crisis that has medical community grasping for alternative treatments. Continue reading to see if CBD (cannabidoil) could be the answer we’ve all been waiting for.

Opioids have been used for Millennia

Opioids are among the world’s oldest drugs, with evidence of their use traced back as far as the Stone Age. Historians and archaeologists have discovered evidence of opioid use among quite a few major civilisations. Now snap forward to modern day, and the continued use of opioid medication is as pervasive as it’s ever been. Legal, pharmaceutical opioid drugs include morphine, methadone, oxycodone, and the extremely powerful fentanyl. Heroin is also an opioid; but thankfully, it is illegal globally.

Opioids in the West have been used since the 19th century thanks to their effective pain-relieving and anaesthetic properties. However, they have a list of side effects longer than your arm ; side effects include sedation, nausea, respiratory depression, and constipation, the list goes on. Together with a high rate of addiction, their potency is a recipe for disaster.

Opioid addiction is on the rise

In a 2017 report by the European Monitoring Centre for Drugs and Addiction it draws attention to just how serious the situation has become. Drug overdose deaths in Europe have risen for the third year in a row, with heroin attributed to many cases. The picture is perhaps worse in North America, with the region experiencing “considerable morbidity and mortality associated with the misuse of prescription opioids”. There is no denying that opioid misuse and addiction are two incredibly challenging issues, but what they do highlight is a clear need for alternative treatment options.

We need alternative options to satisfy two fronts: firstly, pain relief that is not as addictive, and secondly, a medication that can restore to health patients and support the therapy of opioid addiction. It is important understanding how opioids interact with the human body before we discover how CBD could be adifferent treatment that tackles both of these issues.

What is it that opioids do, and how do they function?

Opioids bind to our opioid receptors in our central and peripheral nervous system as well as our GI tract. Once opioids bind to a receptor, they act directly on the central nervous system to diminish the feeling of pain, or in the case of our digestive system, to reduce motor activity and stress response.

Circumstances like the type of opioid, its potency, the location of the receptor, and if it is an agonist or antagonist of that receptor all play a role in the possible biological outcome. With enough research, we could learn to control the reactions taking place. At the moment, there is evidence to support a build-up of tolerance to opioids. Increasing the dosage may be needed to provide the same level of pain relief over time, which in turn leads to greater severity of side effects and an increased likelihood of addiction.

CBD could be the answer in helping to tackle the opioid crisis on multiple fronts

With a deeper understanding of how opioids interact and the risks associated with continued use, it is easy to see how valuable alternative treatments are. The close relationship between cannabinoids, and the endocannabinoid system, and acute or chronic pain have been observed across numerous studies. A noteworthy number of cannabinoid receptors are linked to our nervous system, and it is believed that interactivity between these receptors and cannabinoids could be an alternative route to harmful opioid medication.

CBD was found to “suppress chronic inflammatory and neuropathic pain without causing apparent analgesic tolerance” in a rodent model performed by the Laboratory for Integrative Neuroscience. However, that only potentially solves one half of the issue. The other is discovering non-opioid medications to deal with opioid addiction.

Happily, CBD may have solved this problem as well. A review into the early phase development of cannabidiol as a treatment for addiction found that CBD has the potential “to inhibit drug-seeking behaviour“. The review took into account preclinical animal investigations and human clinical trials, but did acknowledge that “further exploration” was needed to establish CBD’s efficacy as a therapeutic intervention for opioid relapse.

The need for alternative treatments is significant

Alternative treatments for pain—ones that don’t impose the same severity of side effects, and that carry far lower rates of addiction—are paramount. The perfect alternative would be one that is widely accessible, safe, and with minimal potential for abuse. Thankfully, the growing acceptance of cannabinoids and their medicinal use appears to go hand in hand with the base requirements of opioid alternatives. Most appear well-tolerated, and in the case of CBD, “exhibit(s) no effects indicative of any abuse or dependence potential” according to a review by the World Health Organisation.

Both cannabinoids and opioids work using a similar principle—they interact with receptors that trigger biological reactions. Despite their impact on the body being worlds apart, it is this similarity in their mechanism that makes cannabinoids one of the most viable alternatives for treating opioid addiction. As part of a comprehensive treatment programme, the research above indicates that cannabinoids like CBD could potentially be used to break the cycle of addiction associated with opioids.

Only more research and a greater acceptance of cannabinoid-based treatments will ascertain their true potential in tackling addiction and pain management.

Source: https://thecbdoilcompany.co.za/what-you-need-to-know-about-cbd-and-opiods/?utm_source=rss&utm_medium=rss&utm_campaign=what-you-need-to-know-about-cbd-and-opiods

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Medipharm Labs Has Taken Another Major Step Forward To Advance The Company’s Entry Into The Pharmaceutical Sector

Last year, we highlighted MediPharm Labs Corp. (TSX: LABS) (OTCQX: MEDIF) (FSE: MLZ) as one of the most misunderstood and undervalued cannabis companies. Following a series of transformational announcements, we remain bullish on the business and believe that our readers need to be aware of how the story has advanced so far this year. A […]

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Last year, we highlighted MediPharm Labs Corp. (TSX: LABS) (OTCQX: MEDIF) (FSE: MLZ) as one of the most misunderstood and undervalued cannabis companies. Following a series of transformational announcements, we remain bullish on the business and believe that our readers need to be aware of how the story has advanced so far this year.

A few weeks ago, MediPharm Labs announced an important milestone and was issued a Cannabis Drug License (CDL) from Health Canada. The license is necessary for the company to manufacture and supply cannabis-based drugs. The products that are allowed with a CDL include pharmaceutical prescription drugs that have a drug identification number (DIN).

Through this achievement, MediPharm is positioned to be an essential part of the pharmaceutical industry supply chain and we consider this to be a major market opportunity for it. During the last few years, interest in pharmaceutical products that are derived from cannabis has been steadily increasing. MediPharm’s management team executed flawlessly on a strategy to be granted a CDL and we consider this to be a testament to the strength and perseverance of the management team.

Unlike many publicly traded cannabis companies, MediPharm is led by a management team that is focused on executing on previously announced growth initiatives and the granting of the CDL is a perfect example of this.

Going forward, the opportunity for MediPharm with its existing pharmaceutical customers to produce existing approved cannabis drugs or develop and manufacture new and innovative drugs through later stage clinical trials is significant and believe the market is missing out on something substantial.

Another reason we are favorable on the granting of the CDL is due to the potential for MediPharm to work with additional large and smaller pharmaceutical companies. Currently, there are thousands of active cannabis focused clinical trials taking place and we expect the CDL to serve as a substantial growth driver for the business over the long-term.

In the near-term, MediPharm is well positioned to supply cannabis based pharmaceutical drugs and active pharmaceutical ingredients (APIs) to other CDL license holders and clinical research trials for novel drug discovery. We believe the market is discounting the impact that this initiative will have on the business and find the risk-reward profile to be favorable.

During the last year, MediPharm has reported transformational developments and we expect these changes to lead to revenue growth, margin appreciation, and multiple expansion. At current levels, MediPharm is trading at a substantial discount to its peers and believe this disconnect is going to change as the management continues to execute and create value for shareholders.

If you are interested in learning more about how MediPharm Labs is positioned to capitalizing on an emerging vertical of the cannabis industry, please send an email to support@technical420.com with the subject “MediPharm Labs” to be added to our distribution list.

Pursuant to an agreement between StoneBridge Partners LLC and Medipharm Labs we have been hired for a period of 180 days beginning August 18, 2020 and ending March 18, 2021 to publicly disseminate information about (LABS) including on the Website and other media including Facebook and Twitter. We are being paid $6,000 per month (LABS) for or were paid “ZERO” shares of unrestricted or restricted common shares. We own zero (0) shares of (LABS), which we purchased in the open market. We plan to sell the “ZERO” shares of (LABS) that we hold during the time the Website and/or Facebook and Twitter Information recommends that investors or visitors to the website purchase without further notice to you. We may buy or sell additional shares of (LABS) in the open market at any time, including before, during or after the Website and Information, provide public dissemination of favorable Information.

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Michael Berger

Michael Berger is Managing Partner of StoneBridge Partners LLC. SBP continues to drive market awareness for leading firms in the cannabis industry throughout the U.S. and abroad.

Source: https://technical420.com/cannabis-article/medipharm-labs-has-taken-another-major-step-forward-to-advance-the-companys-entry-into-pharmaceutical-sector/

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Pure Extracts Submits Multiple SKUs to Health Canada for Approval

Pure Extracts Technologies Corp. (CSE: PULL) (OTC: PRXTF) (XFRA: A2QJAJ) (“Pure Extracts” or the “Company”), a plant-based extraction company focused on cannabis, hemp, functional mushrooms and the rapidly emerging psychedelic sector, is pleased to announce that its wholly owned subsidiary, Pure Extracts Manufacturing Corp.’s distribution partner has submitted a Notice of New Cannabis Product (“NNCP”) […]

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Pure Extracts Technologies Corp. (CSE: PULL) (OTC: PRXTF) (XFRA: A2QJAJ) (“Pure Extracts” or the “Company”), a plant-based extraction company focused on cannabis, hemp, functional mushrooms and the rapidly emerging psychedelic sector, is pleased to announce that its wholly owned subsidiary, Pure Extracts Manufacturing Corp.’s distribution partner has submitted a Notice of New Cannabis Product (“NNCP”) application to Health Canada on behalf of the company seeking approval for its retail cannabis products including cannabis extracts and edible cannabis.

The company submitted over 20 Stock Keeping Unit (SKU) product identifiers for approval including THC vapes, CBD vapes, 1:1 blended vapes, and 3 different flavours/formulations of gummies. The company plans to launch these products under its ‘Pure Pulls Vapes’ and ‘Pure Chews Gummies’ branded product lines and is looking forward to having them listed for sale with provincially authorized distributors and retailers nationwide.

Pure Extracts is continuing to develop its portfolio of cannabis 2.0 products with emphasis on its 34 proprietary formulations of ‘Pure Pulls’ branded full spectrum oil (FSO) vape products and on its new line of ‘Pure Chews’ edible gummies manufactured under license from Taste-T, LLC, the manufacturer of Fireball cannabis gummies.

Pure Extracts CEO, Ben Nikolaevsky, remarked, “We create products that are in high demand by provincially authorized distributors and retailers nationwide, and are looking forward to having our high quality, FSO products in consumers’ hands early in Q2 of this year.”

About Pure Extracts Technologies Corp. (CSE: PULL) (OTC: PRXTF) (XFRA: A2QJAJ)
Pure Extracts features an all-new, state-of-the-art processing facility located just 20 minutes north of world-famous Whistler, British Columbia. The bespoke facility has been constructed to European Union GMP standards aiming towards export sales of products and formulations, including those currently restricted in Canada, into European jurisdictions where they are legally available. On September 25, 2020, Pure Extracts was granted its Standard Processing License by Health Canada under the Cannabis Act and the Company’s stock began trading on the Canadian Securities Exchange (CSE) on November 5, 2020. Find out more at https://pureextractscorp.com/.

For further information please contact Empire Communications Group at (604) 343-2724.

ON BEHALF OF THE BOARD
Ben Nikolaevsky
Ben Nikolaevsky
CEO and Director

The CSE has neither approved nor disapproved the contents of this press release.

This news release contains forward-looking statements relating to the future operations of Pure Extracts, and the other statements are not historical facts. Forward-looking statements are often identified by terms such as “will”, “may”, “should”, “anticipate”, “expects” and similar expressions. All statements other than statements of historical fact, included in this release, including, without limitation, statements regarding the future plans and objectives of Pure Extracts’, are forward-looking statements and involve risks and uncertainties. There can be no assurance that such statements will prove to be accurate and actual results and future events could differ materially from those anticipated in such statements. Important factors that could cause actual results to differ materially from the expectations of Pure Extracts include risks detailed from time to time in the filings made by Pure Extracts under securities regulations.

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Michael Berger

Michael Berger is Managing Partner of StoneBridge Partners LLC. SBP continues to drive market awareness for leading firms in the cannabis industry throughout the U.S. and abroad.

Source: https://technical420.com/cannabis-article/pure-extracts-submits-multiple-skus-to-health-canada-for-approval/

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What CBD Oil is Right For Me?

What CBD Oil is Right For Me? There are so many wonderful cannabis products out there, but the big question you are probably asking yourself is: What CBD Oil is Right For Me? First off, let’s get this little disclaimer out of the way so we can carry on. Every one reacts to cannabis differently, […]

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What CBD Oil is Right For Me?

There are so many wonderful cannabis products out there, but the big question you are probably asking yourself is: What CBD Oil is Right For Me?

First off, let’s get this little disclaimer out of the way so we can carry on.

Every one reacts to cannabis differently, so expect some trial and error when exploring the best oil-option for you.

Now that that’s out of the way, we can move on to some interesting and helping tips to help you choose and decide.


Choosing How To Take CBD

CBD oil products come in a wide range of concentrations, meaning some have higher doses of cannabidiol than others.

The higher the concentration, the more potent the CBD oil is.

You can choose to take CBD in a capsule or as a straight-up oil – the method is entirely up to you.

CBD-Capsule

If you’re easily confused by milligrams or percentages like I was, it’s important to know two things: some products contain the amount of CBD in milligrams, for example: 300mg’s, while others will include the percentage, for example: 28% CBD.

No matter what number the company has listed, the higher it is, the stronger or more potent the oil will be.


I’m Just Starting To Use CBD Oil

If you’re new to the CBD oil world, just use what I like to call: ” The Marijuana Mantra” which goes a little something like this:

picture of a cannabis leaf for edible marijuana

“Dose LOW and Dose SLOW”

— The Marijuana Mantra


You can gradually work your way up to higher doses. Just notice how it affects your body, and then adjust accordingly.

If you’re using CBD for medicinal purposes, most MD’s (at least here in Canada) will encourage you to start at 0.5 ml, for example, for three days and then increase slightly again after 3 days.

Subtlety is key, so your body can adjust and regulate what’s going on and you can too!


What Are The Different Kinds of CBD?

There are two most common types of CBD Oil. Full-spectrum CBD, and CBD isolate.

Full-spectrum oils contain all of the active cannabinoids and terpenes found within the plant, while CBD isolate is pure cannabidiol, and nothing else.

With a full-spectrum CBD oil, it encourages what’s called the entourage effect. It’s when cannabinoids AND terpenes (natural chemicals found within the cannabis plant) boost each other’s effects while they interact and mingle inside your body.

Isolate oils do not, because the terpenes are removed – so there are benefits to both oils, and your body needs to show you which one works best.

Homemade cannabis capsules with cbd

CBD Oil VS Capsules

Just as important as choosing the right concentration, you should consider how you’re going to consume CBD.

You can take CBD oil sublingually (meaning: under the tongue) with an oil dropper, or you can choose to get CBD capsules or gummies which is easy to eat and easier to manage the dosage.

These products still contain the same active ingredients, but the onset and actual duration of effects might vary from person to person.

When you take CBD oil under your tongue, the cannabinoid has a direct path to the bloodstream and your absorption rate is higher.

But that being said, when the effects of edibles or capsules do start – they actually last longer than if you took it under the tongue!

It just depends on your lifestyle, and desired effects.

the difference between cbd and cbg

CBD On A Budget

If you’re on a budget or financially strapped, you’ll need to take price into consideration.

CBD oils with a higher concentration might be slightly more pricey, but it means it may last longer so you won’t have to constantly order, wait and pay for shipping frequently.

Check for companies who are transparent and honest with their numbers, tests and results.

You can feel great knowing that you have a high-quality, lab-tested, and certified product to put into your body.


The Bottom Line

The bottom line is that there isn’t a ‘best’ CBD oil for any particular person, circumstance or wellness goal.

Talk with your medical professionals, and determine what to start with, and create a journal or note on your smartphone to document your feelings.

Feeling better? Keep going!

Feeling not-so-hot? Change the type, dose or frequency of ingestion to start noticing the wonderful and beneficial effects of CBD oil.


To learn more about how you can cook with CBD oil, or create yummy recipes check out our recipe index here.

If you’re looking to up-level your canna-cooking game, you may want to start here.

Share our post and comment below! We’d love to hear from you.

Source: https://www.cannadish.net/what-cbd-oil-is-right-for-me/

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