Cannabigerol or CBG is a non-psychoactive compound that is naturally present in the cannabis plant.
Several studies highlight the difficulty in the classification of the compounds present in the cannabis plant due to the genetic variability. This is the challenge that is progressively addressed.
These are the two vital compounds found in Tea. Quite simple, is it not?!
Therefore, in this article, I am going to try and make it simple and easy to help you understand about CBG. I am happy to share this open-minded discussion on the different compounds of Cannabis plants. Because studies on cannabis are increasingly applied in a multitude of domains, including folk medicine, pharmaceuticals, construction, recreational use, forensic science, genetic engineering, and textile fiber, bioplastic, and more.
When we increase our awareness and knowledge in science, we could try and apply this in our day to day lives.
Genetics of CBG
Reports claim that CBG is the precursor to the more commonly known cannabinoids CBD and THC. In the post, what is CBN? We understood that it is the non-enzymatic oxidation by-product of THC that is derived after prolonged storage at high temperatures.
Conversely, CBG is the compound that is present in the cannabis plant. Moreover, it is accumulated in certain types of cannabis Sativa L. But what is cannabis Sativa L?
‘Cannabis’ is the name of the plant. ‘Sativa’ means ‘sown’ indicating the cultivated form of the plant, and ‘L’ refers to Carolus Linneaeus, the Swedish botanist who was the first to scientifically classify this herb in the year 1745.
A 2005 research that focussed on the study of CBG reports that plants that have a strong CBG potent have been found in different fiber hemp accessions. This is because cannabis research that focussed on evaluating its medicinal properties classified them into several phenotypes.
Phenotype classifications are based on their height, color, and length of leaf, including their chemical constituency.
A 2016 study reports that in 1971, cannabis was first characterized into two phenotypes.
- Drug Type
- Fiber Type
Firstly, When the THC: CBD ratio is > 1, it was classified under the drug type.
Secondly, when the ratio is < 1, it got grouped in the fiber type category. Studies that succeeded this added that if THC: CBD was close to 1 was called an intermediate category.
In 1987, another finding contributed about one more chemical variation that had very low THC and CBD but with a predominant constituent, CBG.
Similarly, a 2018 study reported three Species:
- a fiber-type, named C. Sativa L.,
- a drug-type, characterized by high levels of the psychoactive compound THC (Δ9-THC), named C. indica Lam.,
- and that had intermediate properties, named C. ruderalis Janisch.
Moreover, this study further added that the fiber type ( C.Sativa) is divided into five different chemotypes ( based on their cannabinoid composition).
The table below would aid assist in easy understanding.
|I||drug type plants with a predominance of Δ9-THC-type cannabinoids||-Medicinal or recreational purposes,
|II||plants with intermediate characteristics between drug-type and fiber-type plants||-Textile or food purpose|
|III & IV||fiber-type plants containing high levels of nonpsychoactive cannabinoids and very low amounts of psychoactive ones|| Textile or food purposes
– Contain cannabinoid acids, cannabidiolic acid (CBDA), cannabigerolic acid (CBGA), followed by their decarboxylated forms: cannabidiol (CBD) and cannabigerol (CBG)
|V||fiber-type plants containing almost no cannabinoids||– European countries have approved for commercial use.
-The Commercial value of hemp and a legal limit of 0.2-0.3% THC is usually applied.
Therefore, the different cannabinoids present in the cannabis plant possess distinct characteristics. Although the measurements of its most dominant cannabinoids THC and CBD play a prominent role, some of the other factors that contribute to this difference could be summarized as:
- Environmental parameters, fertilization
- Sex of the plant
- Interaction of genes
- Growth stage, harvest time
- Storage conditions, etc
Uses of Cannabigerol
Firstly research on CBG and its potential health benefits is limited and prevailing studies that primarily discuss the genetics of CBG range from the year 2005- 2016. Hence, it is indispensable to mention that clinical studies or evidence-based research in this domain are rather slow compared to the speed at which technology is advancing. This is due to the complexity of pharmacological research.
However, studies reveal that:
- CBG is the non-psychotropic phytocannabinoid,
- It may exert beneficial actions with therapeutic potential via cannabinoid receptors.
Therefore CBG’s potential to impact Inflammatory bowel diseases ( on animal models), Glaucoma, bladder dysfunctions, neuroprotective properties, bacterial infections, cancer conditions, appetite stimulation, are promising. But research is yet to prove CBG’s interaction in the body.
Wrap up points
- CBG is a non-psychoactive compound and a precursor to the popular cannabinoids CBD and THC
- CBG has slowly started gaining popularity among different sections of society.
- Commercial hemp varieties have CBG and CBGA as the predominant cannabinoids
- It is considered to be used in the unregulated market for hemp oils and derivates
- Large scale research and studies are essential to present the potential pharmacological benefits of phytocannabinoids that includes CBG, CBN, CBC, and CBDV.
Newbie q: Is Broad Spectrum worth taking over Isolate?
Does the extra substances in Broad spectrum really have any benefit without any THC?
I read the following but I dont know enough yet to agree or not: “You cannot get an entourage effect without THC. You cannot therefore completely extract the THC and call it anything but an isolate. You most certainly cannot claim it gives “the benefits of a full spectrum” because it literally cannot do so. There is no such thing as “broad spectrum.” It’s a nonsense term that companies selling isolates are using to trick you into buying their weakened products.”
What are the thoughts of people, esp. those who’ve tried broad and isolate?
HOPE™ Products for Autism Launch in Australia After Earlier US Debuts in Pennsylvania and Louisiana
Zelira Therapeutics Ltd (ASX: ZLD, OTCQB: ZLDAF) just announced that its proprietary cannabinoid medicines, HOPE 1™ and HOPE 2™are now available by prescription to patients in Australia. The HOPE™ forumations, developed by Zelira and noted autism advocate Erica Daniels, first launched in 2019 in Pennsylvania and this fall in Louisiana. “We have had great success […]
Zelira Therapeutics Ltd (ASX: ZLD, OTCQB: ZLDAF) just announced that its proprietary cannabinoid medicines, HOPE 1™ and HOPE 2™are now available by prescription to patients in Australia. The HOPE™ forumations, developed by Zelira and noted autism advocate Erica Daniels, first launched in 2019 in Pennsylvania and this fall in Louisiana.
“We have had great success with HOPE™ in the US and are thrilled to be able to offer it to patients as a treatment option through the Therapeutic Goods Administration’s (TGA) Special Access Scheme,” says Osagie Imosogie, Chairman of Zelira Therapuetics. “Zelira is proud of this latest achievement in our mission to bring cannabinoid medicine to patients around the world.”
The HOPE™ cannabinoid medicines were developed to support the needs of patients with Autism Spectrum Disorder (ASD) by Daniels and Zelira Therapeutics, which then licensed the proprietary formulas to Ilera Healthcare in Pennsylvania and Ilera Holistic Healthcare in Louisiana. HOPE™ has since established itself as one of the top selling formulated medicinal cannabis products in Ilera Healthcare’s portfolio.
“Autism families are finally beginning to have access to a truly better alternative than the harsh pharmaceuticals of the past and I am so proud that HOPE is now available in Australia,” says Erica Daniels, founder of Hope Grows for Autism and co-creator of the HOPE forumalations. “What started off as a labor of love to find a way to treat my own son is now helping parents around the world.”
HOPE™ is part of Zelira’s family of revenue generating medicinal cannabis formulations. The products consist of two pharmaceutical-grade proprietary formulations developed as pharmaceutical-grade products targeting Autism Spectrum Disorder (ASD) as a disease indication.
“Following the success of the HOPE™ launches in Pennsylvania and Louisiana, we are excited to make these products available to patients and physicians in Australia,” says Dr. Richard Hopkins, Zelira’s global Managing Director. “This represents another key milestone in our commitment to bring the benefits of HOPE™ to patients in global markets.”
How long till I have a “normal” THC high again after vaping CBD?
This week I started vaping CBD to try and cut back on my weed consumption during the week as it was starting to interfere with my college classes. The results have blown me out of the water so far, but I’ve also noticed how dampened my THC highs have become. I’m fine with it during the week as I don’t feel awful waking up after a late night sesh and can get my stuff done, but over the weekend I like to indulge a little more since I’ve cut back so much during the week. About how long does it typically take after pausing CBD consumption (I last vaped around 6 pm yesterday) to feel a full, normal high? I do appreciate the calm nature of the highs when you’re loaded up with CBD but it’s just not as satisfying for me in my free time. Any help appreciated 🙂
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