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Treatment of Fragile X Syndrome with Cannabidiol: A Case Series Study and Brief Review of the Literature

Fragile X syndrome (FXS) is an X-linked dominant disorder caused by a mutation in the fragile X mental retardation 1 gene. Cannabidiol (CBD) is an exogenous phytocannabinoid with therapeutic potential for individuals with anxiety, poor sleep, and cognitive deficits, as well as populations with endocannabinoid deficiencies, such as those who suffer from FXS. The objective of this study was to provide a brief narrative review of recent literature on endocannabinoids and FXS and to present a case…

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Fragile X syndrome (FXS) is an X-linked dominant disorder caused by a mutation in the fragile X mental retardation 1 gene. Cannabidiol (CBD) is an exogenous phytocannabinoid with therapeutic potential for individuals with anxiety, poor sleep, and cognitive deficits, as well as populations with endocannabinoid deficiencies, such as those who suffer from FXS. The objective of this study was to provide a brief narrative review of recent literature on endocannabinoids and FXS and to present a case series describing three patients with FXS who were treated with oral CBD-enriched (CBD+) solutions. We review recent animal and human studies of endocannabinoids in FXS and present the cases of one child and two adults with FXS who were treated with various oral botanical CBD+ solutions delivering doses of 32.0 to 63.9 mg daily. Multiple experimental and clinical models of FXS combine to highlight the therapeutic potential of CBD for management of FXS. All three patients described in the case series exhibited functional benefit following the use of oral CBD+ solutions, including noticeable reductions in social avoidance and anxiety, as well as improvements in sleep, feeding, motor coordination, language skills, anxiety, and sensory processing. Two of the described patients exhibited a reemergence of a number of FXS symptoms following cessation of CBD+ treatment (e.g., anxiety), which then improved again after reintroduction of CBD+ treatment. Findings highlight the importance of exploring the therapeutic potential of CBD within the context of rigorous clinical trials.

Keywords: CBD; cannabidiol; endocannabinoid system; fragile X syndrome; oral solution.

Source: https://pubmed.ncbi.nlm.nih.gov/30944868/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1LgINZmdEb7hTii13TOa5DGOR2cvkVQ2sw4N7-xSaEiod6ucE1&fc=20200804221722&ff=20200814111229&v=2.11.5

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What kind of pod systems can you use with cbd?

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Hey, I’ve recently started using cbd gummy’s to help with my anxiety attacks, but I’ve noticed it doesn’t take effect fast enough to really help. I want to try out vaping it but I am not really interested in using disposables. Can you use any kind of pod systems to vape eliquid?

Source: https://www.reddit.com/r/CBD/comments/l49kgi/what_kind_of_pod_systems_can_you_use_with_cbd/

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pre-made tincture are more expensive?

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I’ve been looking around for tinctures, mainly full spectrum 1000mg/30 mL. The price for this has been hovering around $60-$70 from several vendors. However as I was browsing through powders, I found 1000mg full spectrum powder for just $30 at cbdistillery, at half the cost of pre-made full spectrum tincture. Is the price difference mainly just convenience? Pre-made tinctures seem to be far more expensive than a DIY. I understand you’d need to buy a carrier oil to make a tincture, so the total cost at first purchase would be more than $30, but one would be set for making additional cbd tinctures in the future.

Source: https://www.reddit.com/r/CBD/comments/l49ga2/premade_tincture_are_more_expensive/

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Have you guys noticed any synergetic effect of drinking coffe after/before taking cbd?

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Visit our community site for vetted suppliers at http://theCBD.place. It’s time that this subject was given more internet exposure. We are here to discuss topics related to medical marijuana and our experiences using CBD. Please do not assume that anyone here is a medical professional.

Source: https://www.reddit.com/r/CBD/comments/l4749q/have_you_guys_noticed_any_synergetic_effect_of/

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