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The Role of Combination Calcipotriol plus Betamethasone Dipropionate Gel in the Treatment of Moderate-to-Severe Scalp Seborrhoeic Dermatitis
CONCLUSION: CBD gel should be considered as an option for SSD cases not adequately controlled by prior conventional treatment.

Objectives: This study aimed to investigate the off-label use of a combination calcipotriol plus betamethasone dipropionate (CBD) gel in the treatment of moderate-to-severe scalp seborrhoeic dermatitis (SSD).
Methods: This retrospective study involved 32 patients with SSD who were prescribed CBD gel at the Subang Jaya Medical Centre, Selangor, Malaysia, between January 2016 and December 2017. The Physician Global Assessment Scale was used to assess disease severity. Itching/discomfort was evaluated using a visual analogue scale.
Results: The mean age was 35.8 ± 6.9 years. Severe disease was seen in 53.1%. Complete clearance was recorded in 15.6%, 40.6% and 59.4% of patients at weeks two, six and 10, respectively. By week 10, 87.5% had achieved marked improvement. Both mean itching and discomfort scores significantly improved at weeks two, six and 10 (P <0.001). Better outcomes were significantly associated with disease duration and itching intensity and discomfort at presentation (P <0.050).
Conclusion: CBD gel should be considered as an option for SSD cases not adequately controlled by prior conventional treatment.
Keywords: Betamethasone Dipropionate; Calcipotriol Drug Combination; Off-Label Use; Scalp Dermatosis; Seborrheic Dermatitis; Treatment Effectiveness.
Heartland
30 Best Stoner Coloring Books on Amazon
We’ve put together a comprehensive list of the 30 best stoner coloring books on Amazon! These weed-themed coloring books make …
Read more30 Best Stoner Coloring Books on Amazon
The post 30 Best Stoner Coloring Books on Amazon appeared first on The Cannabis School.
We’ve put together a comprehensive list of the 30 best stoner coloring books on Amazon! These weed-themed coloring books make for a fun activity that helps spark your creativity and imagination. Each coloring book found below will have a direct link to it’s listing on Amazon, this will help you easily view or purchase it. Activities like this help enhance the cannabis experience by allowing the user to concentrate on a fun task. The level of your visual indulgence during your “high” is important in determining how much you’ll enjoy it. In other words, what better tools for meditation and recreation than cannabis and coloring?
The condensed list below contains the links to all the best stoner coloring books found in this article:
Condensed List:
- The Stoner’s Psychedelic Coloring Book
- A Coloring Book For Stoners: Stress Relieving Psychedelic Art For Adults
- Let’s Get High And Color: An Adult Coloring Book
- Stoner Things: Stoner Coloring Book
- Stoner Things Volume 2: Colouring Book for Adults
- Princess Stoner Coloring Book
- Disney Princess Stoner Coloring Book:
- Princess Stoner Coloring Book: Great Coloring Book For Adults Stress Relief & Relaxation
- Princess Coloring Book: Cool and Relaxing Design – Great Coloring Book for Adults Relaxation and Stress Relief
- Disney Stoner Colouring Book:
- The Stoner Babes Coloring Book By Katie Guinn
- Trippy Chicks Adult Coloring Book
- Stoner Coloring Book: The Psychedelic Coloring Book for Relaxation and Stress Relief, Stoner Coloring
- Animals Smoking Weed: Colouring Book By Kristin Harris
- Wiz Khalifa’s Weed Farm Coloring Book
- Fresh Baked Cannabis Coloring Book for Weed Lovers: Volume 3
- Fresh Baked Cannabis Coloring Book for Weed Lovers: Fun Marijuana and Pot Themed Images to Color – Volume 1
- Fresh Baked Cannabis Coloring Book
- Marijuana Strains: Adult Coloring Book
- Stoner Coloring Book: The Stoner’s Psychedelic Coloring Book
- Trippy Advisor- An Irreverent Coloring Book For Adults:
- Day Trip: The Stoner’s Psychedelic Coloring Book
- Stoner Coloring Book: A Psychedelic Coloring Book for Adults
- Not Your Kids Stoner Coloring Book:
- A Psychedelic Coloring Book For Adults:
- Psychedelic Coloring Book
- The Trippy Hippie Coloring Book
- Reefer Madness Mandala and Quote Coloring Book For Adults:
- Stoner Activity Book
- High Life Coloring & Activity Book (Volume 1)

Red, glossy eyes are the trademark of a good high. This stoner coloring book features 25 hand-drawn stoner designs for you to color. With 50 pages in total, you don’t even have to worry about ruining the next page’s design with your color’s tint.
It comes in two price variants, $7.99 for paperback and $20.49 for a spiral bound book, perfect for gifts! Oh and it has a free PDF inside too!
Product Features:
- 25 unique designs
- 50 single side printing on both white and black papers
- Available in paperback and spiral bound variants
- Free PDF!
If you liked this, check out a similar one below:

Price: $4.99

Get your hands on this humorous coloring book which includes 17 unique designs and “black light” versions of 15 of them, making a total of 33 pages to color!
Product Features:
- 66 total pages with 33 single-side printed pages to color
- 17 unique designs
- Glossy paper
- Suitable for pencil colours, markers, pens and crayons

With the title inspired by the Netflix hit show “Stranger Things”, this is a perfect gift for fans of the show! The book includes 16 unique designs and also includes inverted background versions for many of them. One of the best stoner coloring books.
Product Features:
- 31 pages to colour
- 16 unique designs
- Glossy paper
- Suitable for color pencils, pens, markers and crayons.
Not quite satisfied? Check out another “Stranger Things” inspired option below!


Calling all our stoner girls! This Disney princess inspired stoner coloring book has all your favourite Disney princess stories with a 420 twist. Now you get to reimagine all the fairytales while in your most creative state.
Product Features:
- 27 unique designs 54 pages in total
- Single side high quality printed pages
- Suitable for colouring pencils, markers, crayons etc
If you liked this theme, check out similar princess stoner colouring books below!




Another one for our Disney lovers, because who doesn’t love this dynamic six! We can already hear Donald Duck’s high quacks!
Product Features:
- 25 unique illustrations
- High quality paper
- Single side printing
- 8.5*11 inches size

This artistic representation of empowered women and gender fluid people who relish the herb is a wonderful gift for all the intellectual and mindful people in your friend circle. With over 60 intricate images of tattoos, marijuana bouquets, patterned garb, shape-filled backgrounds and gorgeous faces, you’ll find new meanings to life inspired by the art in this colouring book!
Product Features:
- 60 single-sided printed pages
- High-quality paper
- 8.5*11 inches size
- Suitable for pencil colours, crayons, markers etc.
If you liked this artistry, then check out the next similar one below!

The Trippy Chicks Coloring book features mystical women channelling their inner goddesses. Expect to find religious symbols, long locks, reptiles and mandalas.

Presenting another gift option for our stoner guys, although with designs so intricate and detailed, even the girls won’t be able to resist it. You can draw for days on end with this book, filling it with colours and creating your own psychedelic paradise.
Product Features:
- Premium glossy cover
- Single sided pages to avoid bleed through
- 8.5*11 inches size
- High quality white paper

From the Dinosaurs of Jurassic Park to reefer madness and game of stoned, this book is guaranteed to leave you in fits of laughter. Kristin Harris really amped up his game with this one!
Product Features:
- 26 unique images
- Test image to try out your colors
- High-quality paper
- 8.5*11 inches size

Wiz Khalifa is back yet again with a pro-cannabis statement in the form of his new product “The Wiz Khalifa Weed Farm Coloring Book”.
This stress-relieving coloring book is slightly on the pricier edge, going at $14.95, but is rightly so, because with featured iconic images from LA to Amsterdam and events like Danksgiving and Wiz’s Birthday, it’s a direct sneak peek into Khalifa’s weed empire!

The Fresh Baked series is a designer brainchild of independent artists who came together to design fun pot-themed images and humourous marijuana designs for people who like to relieve stress through coloring while high.
Product Features:
- Fun cannabis inspired designs
- Original images
- High-quality paper
- 8.5*11 inches size
- Part of a series of three
If you liked this, be sure to check out Fresh Baked Volume 1 and 2! A perfect gift bundle for Birthdays or Christmas!


Not all Cannabis is the same. There are a ton of varieties and so many different strains to choose from. Check out this colouring book that not only lets you have a fun time with Cannabis, but also educates you on the different varieties out there. The book has illustrations of popular strains like the Harlequin, Grape Ape, Dance World, Cherry Pie, Frankenstein, and Laughing Buddha. One of the best stoner coloring books.
So gather your friends and take turns to color and try the Cannabis varieties drawn in the book, who knows, you may find your next favourite party strain here!
Product Features:
- Paperback
- Unique Illustrations
- Cannabis strain designs
- 8.5*11 inches size

Does your trip make you feel like a part of an alternate universe too? If so, you will love this coloring book that transports you directly into a psychedelic world.
Product Features:
- 30 high quality illustrations
- Single side printing to avoid bleed through
- 8.5 x 11’’ size
If you liked this, check out similar books that also promise a great trip!






Marijuana, meditate and contemplate: that’s our mantra. With 35 unique and beautiful kaleidoscopic designs, color in magical mushrooms and mandalas and make your trip a memorable one.
Product Features:
- 8.5*11 sized pages
- Single-sided printing on white paper
- 35 unique illustrations
- High quality 60lb paper
If you like coloring in Mandalas, check out these two as well:



We saved the absolute best for the last. Get your hands on the Stoner Activity Book that not only has coloring pages, but also crosswords, puzzles, trippy mazes and more for a variety of activities to do while high!
If you like this type of product, also check out this stoner coloring and activity book:

So there you have it! The 30 best stoner coloring books on Amazon! If you enjoyed this list, check out our article on the 30 Best Stoner Gifts on Amazon! Leave a comment with what you would like to see next!
Source: https://www.thecannaschool.ca/best-stoner-coloring-books/
Heartland
Antioxidant Function of Phytocannabinoids: Molecular Basis of Their Stability and Cytoprotective Properties under UV-irradiation
In this contribution, a comprehensive study of the redox transformation, electronic structure, stability and photoprotective properties of phytocannabinoids is presented. The non-psychotropic cannabidiol (CBD), cannabigerol (CBG), cannabinol (CBN), cannabichromene (CBC), and psychotropic tetrahydrocannabinol (THC) isomers and iso-THC were included in the study. The results show that under aqueous ambient conditions at pH 7.4, non-psychotropic cannabinoids are slight or moderate electron-donors…

. 2021 Jan 13;S0891-5849(21)00025-3.
doi: 10.1016/j.freeradbiomed.2021.01.012. Online ahead of print.
Affiliations
Item in Clipboard
Free Radic Biol Med. .
Abstract
In this contribution, a comprehensive study of the redox transformation, electronic structure, stability and photoprotective properties of phytocannabinoids is presented. The non-psychotropic cannabidiol (CBD), cannabigerol (CBG), cannabinol (CBN), cannabichromene (CBC), and psychotropic tetrahydrocannabinol (THC) isomers and iso-THC were included in the study. The results show that under aqueous ambient conditions at pH 7.4, non-psychotropic cannabinoids are slight or moderate electron-donors and they are relatively stable, in the following order: CBD>CBG≥CBN>CBC. In contrast, psychotropic Δ9-THC degrades approximately one order of magnitude faster than CBD. The degradation (oxidation) is associated with the transformation of OH groups and changes in the double-bond system of the investigated molecules. The satisfactory stability of cannabinoids is associated with the fact that their OH groups are fully protonated at pH 7.4 (pKa is ≥ 9). The instability of CBN and CBC was accelerated after exposure to UVA radiation, with CBD (or CBG) being stable for up to 24 h. To support their topical applications, an in vitro dermatological comparative study of cytotoxic, phototoxic and UVA or UVB photoprotective effects using normal human dermal fibroblasts (NHDF) and keratinocytes (HaCaT) was done. NHDF are approx. twice as sensitive to the cannabinoids’ toxicity as HaCaT. Specifically, toxicity IC50 values for CBD after 24 h of incubation are 7.1 and 12.8 μM for NHDF and HaCaT, respectively. None of the studied cannabinoids were phototoxic. Extensive testing has shown that CBD is the most effective protectant against UVA radiation of the studied cannabinoids. For UVB radiation, CBN was the most effective. The results acquired could be used for further redox biology studies on phytocannabinoids and evaluations of their mechanism of action at the molecular level. Furthermore, the UVA and UVB photoprotectivity of phytocannabinoids could also be utilized in the development of new cannabinoid-based topical preparations.
Keywords: (photo)stability; UVA/UVB photoprotection; dermal fibroblasts; electronic structure; keratinocytes; oxidation; phytocannabinoids.
Copyright © 2021 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of Competing Interest J.S. has financial interest in CB21 Pharma Ltd., CBDepot Ltd. and PharmaCan Ltd. J.V. is a president of the scientific board of CB21 Pharma Ltd. All other authors declare that they have no conflicts of interest with the contents of this article.
Heartland
Disposition of Phytocannabinoids, Their Acidic Precursors and Their Metabolites in Biological Matrices of Healthy Individuals Treated with Vaporized Medical Cannabis
Inhalation by vaporization is a useful application mode for medical cannabis. In this study, we present the disposition of Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD), their acidic precursors, and their metabolites in serum, oral fluid, and urine together with the acute pharmacological effects in 14 healthy individuals treated with vaporized medical cannabis. THC and CBD peaked firstly in serum and then in oral fluid, with higher concentrations in the first biological matrices and…

Inhalation by vaporization is a useful application mode for medical cannabis. In this study, we present the disposition of Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD), their acidic precursors, and their metabolites in serum, oral fluid, and urine together with the acute pharmacological effects in 14 healthy individuals treated with vaporized medical cannabis. THC and CBD peaked firstly in serum and then in oral fluid, with higher concentrations in the first biological matrices and consequent higher area under the curve AUCs. Acidic precursors Δ-9-tetrahydrocannabinolic acid A (THCA) and cannabidiolic acid (CBDA) showed a similar time course profile but lower concentrations due to the fact that vaporization partly decarboxylated these compounds. All THC and CBD metabolites showed a later onset with respect to the parent compounds in the absorption phase and a slower decrease to baseline. In agreement with serum kinetics, THC-COOH-GLUC and 7-COOH-CBD were the significantly most excreted THC and CBD metabolites. The administration of vaporized medical cannabis induced prototypical effects associated with the administration of cannabis or THC in humans, with a kinetic trend overlapping that of parent compounds and metabolites in serum. The pharmacokinetics of cannabinoids, their precursors, and their metabolites in biological fluids of individuals treated with vaporized medical cannabis preparations showed a high interindividual variability as in the case of oral medical cannabis decoction and oil. Inhaled medical cannabis was absorbed into the organism earlier than decoction and oil. Cannabinoids reached higher systemic concentrations, also due to the fact that the acid precursors decarboxylated to parent cannabinoids at high temperatures, and consequently, the physiological and subjective effects occurred earlier and resulted with higher intensity. No serious adverse effects were observed.
Keywords: cannabidiol; cannabidiol metabolism; cannabis; medical cannabis.
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