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The potential effects of hemp seed/evening primrose oils on the mammalian target of rapamycin complex 1 and interferon-gamma genes expression in experimental autoimmune encephalomyelitis

The mammalian target of rapamycin (mTOR) has a fundamental role in the metabolism, growth, and regulation of the immune system. The interferon gamma (IFN-γ)derived from T helper 1 (Th1) cells is a prominent pro-inflammatory cytokine in multiple sclerosis (MS) and its animal model, the experimental autoimmune encephalomyelitis (EAE). Due to the exclusive role of rapamycin (RAPA) in mTOR complex 1 (mTORC1) inhibition, essentially Th1 differentiation and IFN-γ production, we evaluated the potential…

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Fig. 3

Pathological analysis of brain sections. Group A, RAPA + HSO/EPO-treated mice showed (A1) a large number of inflammatory cells, strings of the non-myelin axon, neuronophagia, (A2) vacuolation, spongy lesions, and (A3) extensive demyelination; group B, rapamycin-treated mice showed (B1) infiltration of inflammatory cells, (B2) spongiotic zones, and (B3) demyelination; group C, HSO/EPO-treated mice showed (C1), a few inflammatory cells and (C2,3) without spongy lesions and demyelination; group D, EAE mice showed (D1) extensive focal inflammatory cells, (D2) extensive vacuolation, zones of spongy degeneration, and (D3) demyelination; group E1-3, the section of the brain of naive mice exhibited no clinical signs. The first row was stained with H&E, the second and third rows were stained with LFB; F, histological score: 0 = no pathology, 1 = no tissue damage but minor inflammation, 2 = modest inflammation, prime tissue damage and demyelination, 3 = moderate tissue damage (demyelination, neuronal loss, tissue damage, cell death, neuronal vacuolation, and neuronophagia), 4 = necrosis (loss of all tissue elements entirely with associated cellular remains). Data presented as mean ± SEM. *P value ≤ 0.05 is significant. EAE, experimental autoimmune encephalomyelitis; HSO/EPO, hemp seed oil/evening primrose oil; RAPA, rapamycin; H&E, hematoxylin and eosin; LFB, luxol fast blue.

Source: https://pubmed.ncbi.nlm.nih.gov/30607150/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1lg0RU4SkRVNqPFA7e6OZattw-Uzcw0dBEajJBQqmhHlNZ8MdX&fc=20200804212534&ff=20200813215111&v=2.11.5

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Heartland

Republished by Plato

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