Heartland
THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders
There is a strong association between cannabis use and schizophrenia but the underlying cellular links are poorly understood. Neurons derived from human-induced pluripotent stem cells (hiPSCs) offer a platform for investigating both baseline and dynamic changes in human neural cells. Here, we exposed neurons derived from hiPSCs to Δ⁹-tetrahydrocannabinol (THC), and identified diagnosis-specific differences not detectable in vehicle-controls. RNA transcriptomic analyses revealed that THC…

There is a strong association between cannabis use and schizophrenia but the underlying cellular links are poorly understood. Neurons derived from human-induced pluripotent stem cells (hiPSCs) offer a platform for investigating both baseline and dynamic changes in human neural cells. Here, we exposed neurons derived from hiPSCs to Δ9-tetrahydrocannabinol (THC), and identified diagnosis-specific differences not detectable in vehicle-controls. RNA transcriptomic analyses revealed that THC administration, either by acute or chronic exposure, dampened the neuronal transcriptional response following potassium chloride (KCl)-induced neuronal depolarization. THC-treated neurons displayed significant synaptic, mitochondrial, and glutamate signaling alterations that may underlie their failure to activate appropriately; this blunted response resembles effects previously observed in schizophrenia hiPSC- derived neurons. Furthermore, we show a significant alteration in THC-related genes associated with autism and intellectual disability, suggesting shared molecular pathways perturbed in neuropsychiatric disorders that are exacerbated by THC.
Heartland
Placed an order with Plain Jane, didn’t receive order confirmation email.
Hey guys, just want to hear from some people who have ordered from them before and know if thats normal or not. This is my first time ordering from them, I took a screenshot when I checked out and it gave me my order number, I definitely put in the right email and stuff.
Usually most transactions online result in an instant email that notifies they got my order, I got nothing at all, just seems pretty weird and makes me a bit worried.
Is this normal?
Source: https://www.reddit.com/r/CBD/comments/ltugeb/placed_an_order_with_plain_jane_didnt_receive/
Heartland
I Tried Tommy Chong's Good Vibes Protocol CBD & It Changed Everything
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