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Source of cannabinoids: what is available, what is used, and where does it come from?

Cannabis sativa L. is an ancient medicinal plant wherefrom over 120 cannabinoids are extracted. In the past two decades, there has been increasing interest in the therapeutic potential of cannabis-based treatments for neurological disorders such as epilepsy, and there is now evidence for the medical use of cannabis and its effectiveness for a wide range of diseases. Cannabinoid treatments for pain and spasticity in patients with multiple sclerosis (Nabiximols) have been approved in several…

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Cannabis sativa L. is an ancient medicinal plant wherefrom over 120 cannabinoids are extracted. In the past two decades, there has been increasing interest in the therapeutic potential of cannabis-based treatments for neurological disorders such as epilepsy, and there is now evidence for the medical use of cannabis and its effectiveness for a wide range of diseases. Cannabinoid treatments for pain and spasticity in patients with multiple sclerosis (Nabiximols) have been approved in several countries. Cannabidiol (CBD), in contrast to tetra-hydro-cannabidiol (THC), is not a controlled substance in the European Union, and over the years there has been increasing use of CBD-enriched extracts and pure CBD for seizure disorders, particularly in children. No analytical controls are mandatory for CBD-based products and a pronounced variability in CBD concentrations in commercialized CBD oil preparations has been identified. Randomized controlled trials of plant-derived CBD for treatment of Lennox-Gastaut syndrome (LGS) and Dravet syndrome (DS) have provided evidence of anti-seizure effects, and in June 2018, CBD was approved by the Food and Drug Administration as an add-on antiepileptic drug for patients two years of age and older with LGS or DS. Medical cannabis, with various ratios of CBD and THC and in different galenic preparations, is licensed in many European countries for several indications, and in July 2019, the European Medicines Agency also granted marketing authorisation for CBD in association with clobazam, for the treatment of seizures associated with LGS or DS. The purpose of this article is to review the availability of cannabis-based products and cannabinoid-based medicines, together with current regulations regarding indications in Europe (as of July 2019). The lack of approval by the central agencies, as well as social and political influences, have led to significant variation in usage between countries.

Keywords: Dravet syndrome; Lennox-Gastaut syndrome; antiepileptic drugs; cannabidiol; cannabinoids; cannabis-based products; legislation.

Source: https://pubmed.ncbi.nlm.nih.gov/31941643/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=14S2P3JOHoFcMo3M7TFdHK-QVNqlBZlxBx1Kmm5Bxn5762lgWa&fc=20200804222140&ff=20200813015519&v=2.11.5

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Introducing SARMS South Africa

What are SARMS, South Africa? Selective Androgen Receptor Modulator (SARMs) are a novel class of cutting-edge performance enhancing supplements which exhibit similar effects to androgenic drugs but are much more selective in their actions and have minimised side effects. They work by binding to your androgen receptors, through targeted tissue selection. SARMs represent a step […]

The post Introducing SARMS South Africa appeared first on CBD Oil Cape Town – Natural Therapy SA.

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What are SARMS, South Africa?

Selective Androgen Receptor Modulator (SARMs) are a novel class of cutting-edge performance enhancing supplements which exhibit similar effects to androgenic drugs but are much more selective in their actions and have minimised side effects. They work by binding to your androgen receptors, through targeted tissue selection.

SARMs represent a step towards safer class of androgenic supplements and their usage extends beyond muscle building and fat loss and well into the medical space as the medical applications are limitless.

SARMS were in fact created by accident. In the early Nineties a Professor James T Dalton was working on cutting edge treatments for Prostate cancer. When he stumbled across molecule andarine (The first SARM) , although molecule anadarine was not very effective with regards to treating prostate cancer, it showed remarkable effects on enhancing muscle growth.

SARMS development has come a long way since then and these days there are SARMS for all sorts of physical enhancements. The most notable use is in the Body Building world where incredible gains in physical strength and muscle are achieved as well as the promotion of lean muscle and fat loss. In the medical space, there are countless peer reviewed studies that show the medical applications of SARMS in conditions that result in muscle loss, Chemotherapy recovery and weight management to name but a few. In short, SARMS are the cutting edge of medical innovation.

Source: https://naturaltherapy.co.za/2021/01/26/introducing-sarms-south-africa/

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A good oil based sweetener?

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Hello. I hope someone can advice. I have some distillate and I’m mixing it with mct. I’ve found the taste quite harsh. I think a natural based sweetener would take the edge off. Does anyone know of a natural oil based sweeter that would mix well?

Thanks

Source: https://www.reddit.com/r/CBD/comments/l5disn/a_good_oil_based_sweetener/

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CBD and Alcohol: Are They Safe to Mix?

If you’ve been to a bar recently, you may have noticed that CBD has become a staple on cocktail menus. Breweries have also started adding CBD to their beer, claiming it enhances relaxation or negates some of alcohol’s negative effects. What really happens when you mix CBD and alcohol? And is it safe?  Unfortunately, research… View Article

The post CBD and Alcohol: Are They Safe to Mix? appeared first on The CBD Insider.

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cbd and alcohol

If you’ve been to a bar recently, you may have noticed that CBD has become a staple on cocktail menus. Breweries have also started adding CBD to their beer, claiming it enhances relaxation or negates some of alcohol’s negative effects.

What really happens when you mix CBD and alcohol? And is it safe? 

Unfortunately, research is very limited. We know some of their effects, but we’re far from understanding all of the ways they interact together in the body. 

The little we do know is complicated by the fact that everyone processes CBD a little differently, so the effect it has on alcohol consumption is not predictable.

However, there have been no instances of serious adverse effects from mixing the two (apart from the well-known risks of excessive alcohol consumption). And, some studies claim that taking CBD with alcohol may be beneficial

In this article, we’ll explain the benefits and risks of taking alcohol and CBD together. We’ll also look at CBD as a potential hangover cure.  

Table of Contents

  1. How do CBD and Alcohol Interact in the Body?
  2. The Benefits of CBD Oil and Alcohol
  3. The Risks of CBD and Alcohol
  4. Does CBD Help with Hangovers
  5. Is it Safe to Mix Alcohol and CBD?

How do CBD and Alcohol Interact in the Body?

how cbd and alcohol interact

Taking CBD oil and alcohol together initiates hundreds of chemical reactions in the body. Due to limited research, we know very little about these reactions, and when it comes to CBD, many are still a mystery. 

Here’s what we know so far.

Alcohol inhibits your central nervous system, making you less sensitive to pain and other unpleasant sensations, but this also leads to poor motor skills.

Alcohol increases the happiness hormone dopamine, and it is a GABA agonist. When binding with GABA receptors, your stress levels plummet and your confidence rises. 

As the body processes alcohol, it can significantly damage the liver, kidneys, and brain. Uncomfortable side effects are felt the day after excessive drinking in the form of a hangover.

CBD affects the body in some of the same ways as alcohol.

For example, CBD also binds with GABA receptors, causing a sedated, relaxed sensation. CBD boosts levels of hormones like dopamine and serotonin, both mood boosters. This has led some to believe that CBD and alcohol may amplify each other’s effects

However, CBD may also negate some of the negative effects of alcohol. It could protect your cells from the stress caused by alcohol processing and prevent inflammation caused by excess alcohol consumption. 

CBD is not known to have any serious side effects or cause damage to the body. It does not lead to dependency, even when taken in large doses. 

Below, we’ll take a closer look at the benefits and risks of mixing alcohol and CBD. 

The Benefits of CBD Oil and Alcohol

The Risks of CBD and Alcohol

  • CBD and alcohol may cause extreme fatigue and drowsiness: Some claim to feel extremely drowsy after mixing CBD and alcohol, which may be caused by high GABA modulation along with increased serotonin and dopamine levels.   
  • CBD and alcohol may cause dangerous levels of intoxication: If CBD amplifies the effects of alcohol, it could cause higher-than-anticipated intoxication levels, especially for those who are not regular users of either substance. 
  • Mixing CBD and alcohol is unpredictable: There are at least seven mutations of the CB2 receptor (CBD binds to this receptor in the endocannabinoid system), which means people may experience the combination of CBD and alcohol in very different ways. 
  • Mixing CBD and alcohol is not well understood: Due to the lack of research on mixing CBD and alcohol, it is inherently risky to take them together.   

Does CBD Help with Hangovers? 

does cbd help with hangovers

There is no evidence that CBD can “cure” or prevent a hangover. But there is evidence that CBD can reduce the negative symptoms of a hangover

CBD’s anti-inflammatory properties may help to relieve discomfort from headaches and muscle aches caused by alcohol.

CBD has been found to effectively reduce nausea and vomiting, which could prevent stomach aches the morning after. 

Alcohol’s effects on GABA can cause an excess of glutamate in the brain the next day. This imbalance can cause anxiety, nervousness, and jitters. CBD can boost levels of GABA back to normal, decreasing anxiety and moodiness. 

Is it Safe to Mix Alcohol and CBD?

At the moment, it’s not possible to say whether CBD and alcohol are safe to mix. There isn’t enough reliable research to draw a conclusion. 

There have been no serious complications or side effects reported from mixing CBD and alcohol. We theorize that it is likely safe to take them together if both are consumed in low doses because of this anecdotal evidence. 

However, in this case, it may not be worth taking them together. In the above studies, many of the benefits of taking CBD with alcohol were only apparent when CBD was administered in high doses.

Low doses of CBD may not do anything but increase the price of your drink.

Due to a lack of research, we cannot recommend mixing high doses of either substance.

Though, if you drink a bit too much, we recommend taking CBD the morning after to help with hangover symptoms such as headache, nausea, and anxiety. 

The CBD Insider Editorial Team

The mission of The CBD Insider is to provide consumers with a way to find high-quality, safe, and well-formulated CBD products. Our editorial team of passionate industry professionals achieves this mission by providing unbiased, trustworthy, and well-researched reporting about the CBD industry.

Source: https://thecbdinsider.com/knowledge-center/cbd-and-alcohol/

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