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Proteomic characterization of copper stress response in Cannabis sativa roots

Cannabis sativa is an annual herb with very high biomass and capability to absorb and accumulate heavy metals in roots and shoots; it is therefore a good candidate for phytoremediation of soils contaminated with metals. Copper is an essential micronutrient for all living organisms, it participates as an important redox component in cellular electron transport chains; but is extremely toxic to plants at high concentrations. The aim of this work was to investigate copper effects on the root…

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Cannabis sativa is an annual herb with very high biomass and capability to absorb and accumulate heavy metals in roots and shoots; it is therefore a good candidate for phytoremediation of soils contaminated with metals. Copper is an essential micronutrient for all living organisms, it participates as an important redox component in cellular electron transport chains; but is extremely toxic to plants at high concentrations. The aim of this work was to investigate copper effects on the root proteome of C. sativa, whose genome is still unsequenced. Copper stress induced the suppression of two proteins, the down-regulation of seven proteins, while five proteins were up-regulated. The resulting differences in protein expression pattern were indicative of a plant adaptation to chronic stress and were directed to the reestablishment of the cellular and redox homeostasis.

Source: https://pubmed.ncbi.nlm.nih.gov/17352425/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1XAOX_jnjTyCUo06Xbq0lslwi760CIxcWfQx0n9x5BPH5yV1sN&fc=20200804212910&ff=20200814211142&v=2.11.5

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30 Best Stoner Coloring Books on Amazon

We’ve put together a comprehensive list of the 30 best stoner coloring books on Amazon! These weed-themed coloring books make …

Read more30 Best Stoner Coloring Books on Amazon

The post 30 Best Stoner Coloring Books on Amazon appeared first on The Cannabis School.

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We’ve put together a comprehensive list of the 30 best stoner coloring books on Amazon! These weed-themed coloring books make for a fun activity that helps spark your creativity and imagination. Each coloring book found below will have a direct link to it’s listing on Amazon, this will help you easily view or purchase it. Activities like this help enhance the cannabis experience by allowing the user to concentrate on a fun task. The level of your visual indulgence during your “high” is important in determining how much you’ll enjoy it. In other words, what better tools for meditation and recreation than cannabis and coloring?

The condensed list below contains the links to all the best stoner coloring books found in this article:

Condensed List:

  1. The Stoner’s Psychedelic Coloring Book
  2. A Coloring Book For Stoners: Stress Relieving Psychedelic Art For Adults
  3. Let’s Get High And Color: An Adult Coloring Book
  4. Stoner Things: Stoner Coloring Book
  5. Stoner Things Volume 2: Colouring Book for Adults
  6. Princess Stoner Coloring Book
  7. Disney Princess Stoner Coloring Book:
  8. Princess Stoner Coloring Book: Great Coloring Book For Adults Stress Relief & Relaxation
  9. Princess Coloring Book: Cool and Relaxing Design – Great Coloring Book for Adults Relaxation and Stress Relief
  10. Disney Stoner Colouring Book: 
  11. The Stoner Babes Coloring Book By Katie Guinn
  12. Trippy Chicks Adult Coloring Book
  13. Stoner Coloring Book: The Psychedelic Coloring Book for Relaxation and Stress Relief, Stoner Coloring
  14. Animals Smoking Weed: Colouring Book By Kristin Harris
  15. Wiz Khalifa’s Weed Farm Coloring Book
  16. Fresh Baked Cannabis Coloring Book for Weed Lovers: Volume 3
  17. Fresh Baked Cannabis Coloring Book for Weed Lovers: Fun Marijuana and Pot Themed Images to Color – Volume 1
  18. Fresh Baked Cannabis Coloring Book
  19. Marijuana Strains: Adult Coloring Book
  20. Stoner Coloring Book: The Stoner’s Psychedelic Coloring Book
  21. Trippy Advisor- An Irreverent Coloring Book For Adults:
  22. Day Trip: The Stoner’s Psychedelic Coloring Book
  23. Stoner Coloring Book: A Psychedelic Coloring Book for Adults
  24. Not Your Kids Stoner Coloring Book:
  25. A Psychedelic Coloring Book For Adults:
  26. Psychedelic Coloring Book
  27. The Trippy Hippie Coloring Book
  28. Reefer Madness Mandala and Quote Coloring Book For Adults: 
  29. Stoner Activity Book
  30. High Life Coloring & Activity Book (Volume 1)

Red, glossy eyes are the trademark of a good high. This stoner coloring book features 25 hand-drawn stoner designs for you to color. With 50 pages in total, you don’t even have to worry about ruining the next page’s design with your color’s tint. 

It comes in two price variants, $7.99 for paperback and $20.49 for a spiral bound book, perfect for gifts! Oh and it has a free PDF inside too!

Product Features:

  • 25 unique designs
  • 50 single side printing on both white and black papers
  • Available in paperback and spiral bound variants
  • Free PDF!

If you liked this, check out a similar one below:

 Price: $4.99

Get your hands on this humorous coloring book which includes 17 unique designs and “black light” versions of 15 of them, making a total of 33 pages to color! 

Product Features:

  • 66 total pages with 33 single-side printed pages to color
  • 17 unique designs
  • Glossy paper
  • Suitable for pencil colours, markers, pens and crayons

With the title inspired by the Netflix hit show “Stranger Things”, this is a perfect gift for fans of the show! The book includes 16 unique designs and also includes inverted background versions for many of them. One of the best stoner coloring books.

Product Features:

  • 31 pages to colour
  • 16 unique designs
  • Glossy paper
  • Suitable for color pencils, pens, markers and crayons.

Not quite satisfied? Check out another “Stranger Things” inspired option below!

Calling all our stoner girls! This Disney princess inspired stoner coloring book has all your favourite Disney princess stories with a 420 twist. Now you get to reimagine all the fairytales while in your most creative state. 

Product Features:

  • 27 unique designs 54 pages in total
  • Single side high quality printed pages
  • Suitable for colouring pencils, markers, crayons etc

If you liked this theme, check out similar princess stoner colouring books below!

Disney Princess stoner coloring book.
Disney princess stoner coloring book with two girls smoking on the cover.
Disney character stoner coloring book cover.

Another one for our Disney lovers, because who doesn’t love this dynamic six! We can already hear Donald Duck’s high quacks!

Product Features:

  • 25 unique illustrations
  • High quality paper
  • Single side printing
  • 8.5*11 inches size
The stoner babes coloring book cover.

This artistic representation of empowered women and gender fluid people who relish the herb is a wonderful gift for all the intellectual and mindful people in your friend circle. With over 60 intricate images of tattoos, marijuana bouquets, patterned garb, shape-filled backgrounds and gorgeous faces, you’ll find new meanings to life inspired by the art in this colouring book!

Product Features:

  • 60 single-sided printed pages
  • High-quality paper
  • 8.5*11 inches size
  • Suitable for pencil colours, crayons, markers etc.

If you liked this artistry, then check out the next similar one below!

The Trippy Chicks Coloring book features mystical women channelling their inner goddesses. Expect to find religious symbols, long locks, reptiles and mandalas.

Presenting another gift option for our stoner guys, although with designs so intricate and detailed, even the girls won’t be able to resist it. You can draw for days on end with this book, filling it with colours and creating your own psychedelic paradise. 

Product Features:

  • Premium glossy cover
  • Single sided pages to avoid bleed through
  • 8.5*11 inches size
  • High quality white paper
Animals smoking weed stoner coloring book with a fish on the cover smoking a joint.

From the Dinosaurs of Jurassic Park to reefer madness and game of stoned, this book is guaranteed to leave you in fits of laughter. Kristin Harris really amped up his game with this one!

Product Features:

  • 26 unique images
  • Test image to try out your colors
  • High-quality paper
  • 8.5*11 inches size
The Wiz Khalifa's weed farm stoner coloring book.

Wiz Khalifa is back yet again with a pro-cannabis statement in the form of his new product “The Wiz Khalifa Weed Farm Coloring Book”.

This stress-relieving coloring book is slightly on the pricier edge, going at $14.95, but is rightly so, because with featured iconic images from LA to Amsterdam and events like Danksgiving and Wiz’s Birthday, it’s a direct sneak peek into Khalifa’s weed empire!

Fresh baked stoner coloring book volume 3 edition.

The Fresh Baked series is a designer brainchild of independent artists who came together to design fun pot-themed images and humourous marijuana designs for people who like to relieve stress through coloring while high. 

Product Features:

  • Fun cannabis inspired designs
  • Original images
  • High-quality paper
  • 8.5*11 inches size
  • Part of a series of three

If you liked this, be sure to check out Fresh Baked Volume 1 and 2! A perfect gift bundle for Birthdays or Christmas!

Fresh baked stoner coloring book for weed lovers. The cover has a bong smoking a jay.
The fresh baked cannabis coloring book for weed lovers.
Marijuana strains adult coloring book cover. This cover includes a man sitting down meditating with his seven chakras.

Not all Cannabis is the same. There are a ton of varieties and so many different strains to choose from. Check out this colouring book that not only lets you have a fun time with Cannabis, but also educates you on the different varieties out there. The book has illustrations of popular strains like the Harlequin, Grape Ape, Dance World, Cherry Pie, Frankenstein, and Laughing Buddha. One of the best stoner coloring books.

So gather your friends and take turns to color and try the Cannabis varieties drawn in the book, who knows, you may find your next favourite party strain here!

Product Features:

  • Paperback
  • Unique Illustrations
  • Cannabis strain designs
  • 8.5*11 inches size
Stoner coloring book jumbo edition cover, the blue background has stars shining through it.

Does your trip make you feel like a part of an alternate universe too? If so, you will love this coloring book that transports you directly into a psychedelic world. 

Product Features:

  • 30 high quality illustrations
  • Single side printing to avoid bleed through
  • 8.5 x 11’’ size 

If you liked this, check out similar books that also promise a great trip!

Trippy advisor the psychedelic coloring book for stoners. The cover is painted in rainbow with joints on it.
Day trip alien coloring book, made with colorful designs and shapes.
A cover for a stoner coloring book that is sold on amazon. The cover includes designs of mushrooms and fun animals.
"Not your kids coloring books", stoner coloring book with a fun avatar on the front blowing out smoke.
A psychedelic coloring book for adults with a blue woman smoking a joint on the front cover.
A psychedelic coloring book made with colorful patterns and shapes.

Marijuana, meditate and contemplate: that’s our mantra. With 35 unique and beautiful kaleidoscopic designs, color in magical mushrooms and mandalas and make your trip a memorable one. 

Product Features:

  • 8.5*11 sized pages
  • Single-sided printing on white paper
  • 35 unique illustrations
  • High quality 60lb paper

If you like coloring in Mandalas, check out these two as well:

The trippy hippie coloring book cover, including the face of a girl hippie.
Reefer madness stoner coloring book cover with a pot leaf on the front.
A stoner coloring book with a potleaf on the front smoking a joint.

We saved the absolute best for the last. Get your hands on the Stoner Activity Book that not only has coloring pages, but also crosswords, puzzles, trippy mazes and more for a variety of activities to do while high! 

If you like this type of product, also check out this stoner coloring and activity book:

the cover of a Stoner coloring book, high life, by jay anthony

So there you have it! The 30 best stoner coloring books on Amazon! If you enjoyed this list, check out our article on the 30 Best Stoner Gifts on Amazon! Leave a comment with what you would like to see next!

Source: https://www.thecannaschool.ca/best-stoner-coloring-books/

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Antioxidant Function of Phytocannabinoids: Molecular Basis of Their Stability and Cytoprotective Properties under UV-irradiation

In this contribution, a comprehensive study of the redox transformation, electronic structure, stability and photoprotective properties of phytocannabinoids is presented. The non-psychotropic cannabidiol (CBD), cannabigerol (CBG), cannabinol (CBN), cannabichromene (CBC), and psychotropic tetrahydrocannabinol (THC) isomers and iso-THC were included in the study. The results show that under aqueous ambient conditions at pH 7.4, non-psychotropic cannabinoids are slight or moderate electron-donors…

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. 2021 Jan 13;S0891-5849(21)00025-3.

doi: 10.1016/j.freeradbiomed.2021.01.012. Online ahead of print.

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Jan Vacek et al. Free Radic Biol Med. .

Abstract

In this contribution, a comprehensive study of the redox transformation, electronic structure, stability and photoprotective properties of phytocannabinoids is presented. The non-psychotropic cannabidiol (CBD), cannabigerol (CBG), cannabinol (CBN), cannabichromene (CBC), and psychotropic tetrahydrocannabinol (THC) isomers and iso-THC were included in the study. The results show that under aqueous ambient conditions at pH 7.4, non-psychotropic cannabinoids are slight or moderate electron-donors and they are relatively stable, in the following order: CBD>CBG≥CBN>CBC. In contrast, psychotropic Δ9-THC degrades approximately one order of magnitude faster than CBD. The degradation (oxidation) is associated with the transformation of OH groups and changes in the double-bond system of the investigated molecules. The satisfactory stability of cannabinoids is associated with the fact that their OH groups are fully protonated at pH 7.4 (pKa is ≥ 9). The instability of CBN and CBC was accelerated after exposure to UVA radiation, with CBD (or CBG) being stable for up to 24 h. To support their topical applications, an in vitro dermatological comparative study of cytotoxic, phototoxic and UVA or UVB photoprotective effects using normal human dermal fibroblasts (NHDF) and keratinocytes (HaCaT) was done. NHDF are approx. twice as sensitive to the cannabinoids’ toxicity as HaCaT. Specifically, toxicity IC50 values for CBD after 24 h of incubation are 7.1 and 12.8 μM for NHDF and HaCaT, respectively. None of the studied cannabinoids were phototoxic. Extensive testing has shown that CBD is the most effective protectant against UVA radiation of the studied cannabinoids. For UVB radiation, CBN was the most effective. The results acquired could be used for further redox biology studies on phytocannabinoids and evaluations of their mechanism of action at the molecular level. Furthermore, the UVA and UVB photoprotectivity of phytocannabinoids could also be utilized in the development of new cannabinoid-based topical preparations.

Keywords: (photo)stability; UVA/UVB photoprotection; dermal fibroblasts; electronic structure; keratinocytes; oxidation; phytocannabinoids.

Conflict of interest statement

Declaration of Competing Interest J.S. has financial interest in CB21 Pharma Ltd., CBDepot Ltd. and PharmaCan Ltd. J.V. is a president of the scientific board of CB21 Pharma Ltd. All other authors declare that they have no conflicts of interest with the contents of this article.

Source: https://pubmed.ncbi.nlm.nih.gov/33453360/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1zmroqAMnEquTZFTfdGx1V1gPEavo-Be3-FKTecJpOlB7LykCL&fc=20200804213506&ff=20210117055210&v=2.14.2

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Disposition of Phytocannabinoids, Their Acidic Precursors and Their Metabolites in Biological Matrices of Healthy Individuals Treated with Vaporized Medical Cannabis

Inhalation by vaporization is a useful application mode for medical cannabis. In this study, we present the disposition of Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD), their acidic precursors, and their metabolites in serum, oral fluid, and urine together with the acute pharmacological effects in 14 healthy individuals treated with vaporized medical cannabis. THC and CBD peaked firstly in serum and then in oral fluid, with higher concentrations in the first biological matrices and…

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Inhalation by vaporization is a useful application mode for medical cannabis. In this study, we present the disposition of Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD), their acidic precursors, and their metabolites in serum, oral fluid, and urine together with the acute pharmacological effects in 14 healthy individuals treated with vaporized medical cannabis. THC and CBD peaked firstly in serum and then in oral fluid, with higher concentrations in the first biological matrices and consequent higher area under the curve AUCs. Acidic precursors Δ-9-tetrahydrocannabinolic acid A (THCA) and cannabidiolic acid (CBDA) showed a similar time course profile but lower concentrations due to the fact that vaporization partly decarboxylated these compounds. All THC and CBD metabolites showed a later onset with respect to the parent compounds in the absorption phase and a slower decrease to baseline. In agreement with serum kinetics, THC-COOH-GLUC and 7-COOH-CBD were the significantly most excreted THC and CBD metabolites. The administration of vaporized medical cannabis induced prototypical effects associated with the administration of cannabis or THC in humans, with a kinetic trend overlapping that of parent compounds and metabolites in serum. The pharmacokinetics of cannabinoids, their precursors, and their metabolites in biological fluids of individuals treated with vaporized medical cannabis preparations showed a high interindividual variability as in the case of oral medical cannabis decoction and oil. Inhaled medical cannabis was absorbed into the organism earlier than decoction and oil. Cannabinoids reached higher systemic concentrations, also due to the fact that the acid precursors decarboxylated to parent cannabinoids at high temperatures, and consequently, the physiological and subjective effects occurred earlier and resulted with higher intensity. No serious adverse effects were observed.

Keywords: cannabidiol; cannabidiol metabolism; cannabis; medical cannabis.

Source: https://pubmed.ncbi.nlm.nih.gov/33451073/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1TUbR4JfRTv1rbahLd1HaiF0w5ryO5ocWB3_xk3Prq78L0AEhI&fc=20200804222312&ff=20210117023326&v=2.14.2

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