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Pharmacology of Medical Cannabis

The Cannabis plant has been used for many of years as a medicinal agent in the relief of pain and seizures. It contains approximately 540 natural compounds including more than 100 that have been identified as phytocannabinoids due to their shared chemical structure. The predominant psychotropic component is Δ⁹-tetrahydrocannabinol (Δ⁹-THC), while the major non-psychoactive ingredient is cannabidiol (CBD). These compounds have been shown to be partial agonists or antagonists at the prototypical…

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The Cannabis plant has been used for many of years as a medicinal agent in the relief of pain and seizures. It contains approximately 540 natural compounds including more than 100 that have been identified as phytocannabinoids due to their shared chemical structure. The predominant psychotropic component is Δ9-tetrahydrocannabinol (Δ9-THC), while the major non-psychoactive ingredient is cannabidiol (CBD). These compounds have been shown to be partial agonists or antagonists at the prototypical cannabinoid receptors, CB1 and CB2. The therapeutic actions of Δ9-THC and CBD include an ability to act as analgesics, anti-emetics, anti-inflammatory agents, anti-seizure compounds and as protective agents in neurodegeneration. However, there is a lack of well-controlled, double blind, randomized clinical trials to provide clarity on the efficacy of either Δ9-THC or CBD as therapeutics. Moreover, the safety concerns regarding the unwanted side effects of Δ9-THC as a psychoactive agent preclude its widespread use in the clinic. The legalization of cannabis for medicinal purposes and for recreational use in some regions will allow for much needed research on the pharmacokinetics and pharmocology of medical cannabis. This brief review focuses on the use of cannabis as a medicinal agent in the treatment of pain, epilepsy and neurodegenerative diseases. Despite the paucity of information, attention is paid to the mechanisms by which medical cannabis may act to relieve pain and seizures.

Keywords: CBD; Cannabinoids; Medicinal; THC.

Source: https://pubmed.ncbi.nlm.nih.gov/31332738/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1TQbL92JdzYTve0m3OsSoggMby2JyZDVBLRHiDMYZkT1hs6YNQ&fc=20200804223051&ff=20200815134947&v=2.11.5

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CBD Dabs/flower? What should I expect?

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So I’ve been staying off weed since march of this year so I could pass drug tests for work if I needed to and now since I get my first paycheck pretty soon I’ve been thinking about CBD flower or Dabs specifically dabs. I had mostly smoked flower and got carts (from disp) but I had only done dabs once. but the torch I had gotten was pretty cheap and it had melted whilst using it and I didn’t properly do it so I had to kind of free base what I had. But since then I’ve thought that maybe doing CBD dabs would be a better alternative to tincture since it get’s to the head quicker and my tolerance for weed is about 0. But I’m still iffy considering the reputation Dabs have. I’ve been taking a look at different brands but secret nature and extract labs have kind of got my attention. Both have a pretty good reputation and secret nature has lab test PDFs and codes you can scan with their flower and extracts. But I’m still pretty on the fence on what to do personally. I feel like I’d be better off with flower but I don’t want to smell like weed and I don’t want to burn my lungs off taking a hot dab.

Source: https://www.reddit.com/r/CBD/comments/jgtg60/cbd_dabsflower_what_should_i_expect/

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Switching to CBD Carts to get off THC carts?

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Visit our community site for vetted suppliers at http://theCBD.place. It’s time that this subject was given more internet exposure. We are here to discuss topics related to medical marijuana and our experiences using CBD. Please do not assume that anyone here is a medical professional.

Source: https://www.reddit.com/r/CBD/comments/jgsr8u/switching_to_cbd_carts_to_get_off_thc_carts/

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Ascariasis in common bile duct resulting in a subhepatic abscess

CONCLUSIONS: Ascariasis should be considered in endemic areas and early endoscopic intervention and medical therapy can be effective for extrahepatic involvement.

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Case Reports

. Jul-Sep 2020;83(3):488-490.

Affiliations

  • PMID: 33094600

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Case Reports

B C Anzali et al. Acta Gastroenterol Belg. .

Abstract

Background: Biliary system ascariasis can be a rare cause of acute abdomen.

Patient report: A 70-year-old woman presented with abdominal pain for two weeks. She complained of a right upper quadrant (RUQ) pain, intermittent vomiting and weight loss. Physical examination showed RUQ and epigastric tenderness without rebound tenderness or guarding. Laboratory finding exhibited leukocytosis and mildly elevated liver enzymes.

Results: Abdominal sonography showed distended gallbladder and a tubular lesion inside the common bile duct (CBD) in favor of a parasitic lesion. A large ascaris roundworm and blood clots were extracted from the CBD by endoscopic retrograde cholangiopancreatography and sphincterotomy. After 7 days, the disease process was complicated with a subhepatic abscess formation which was managed conservatively. Finally, the patient was discharged home in fair condition after 12 days of hospitalization.

Conclusions: Ascariasis should be considered in endemic areas and early endoscopic intervention and medical therapy can be effective for extrahepatic involvement.

Keywords: Abdominal abscess; abdominal pain; ascariasis; common bile duct; endoscopic retrograde cholangiopancreatography.

Conflict of interest statement

The authors declare that they have no conflict of interest

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Source: https://pubmed.ncbi.nlm.nih.gov/33094600/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=14S2P3JOHoFcMo3M7TFdHK-QVNqlBZlxBx1Kmm5Bxn5762lgWa&fc=20200804222140&ff=20201023141346&v=2.12.6

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