Connect with us

Heartland

Pharmacokinetics, Safety, and Clinical Efficacy of Cannabidiol Treatment in Osteoarthritic Dogs

Objectives: The objectives of this study were to determine basic oral pharmacokinetics, and assess safety and analgesic efficacy of a cannabidiol (CBD) based oil in dogs with osteoarthritis (OA). Methods: Single-dose pharmacokinetics was performed using two different doses of CBD enriched (2 and 8 mg/kg) oil. Thereafter, a randomized placebo-controlled, veterinarian, and owner blinded, cross-over study was conducted. Dogs received each of two treatments: CBD oil (2 mg/kg) or placebo oil every 12…

Republished by Plato

Published

on

Objectives: The objectives of this study were to determine basic oral pharmacokinetics, and assess safety and analgesic efficacy of a cannabidiol (CBD) based oil in dogs with osteoarthritis (OA). Methods: Single-dose pharmacokinetics was performed using two different doses of CBD enriched (2 and 8 mg/kg) oil. Thereafter, a randomized placebo-controlled, veterinarian, and owner blinded, cross-over study was conducted. Dogs received each of two treatments: CBD oil (2 mg/kg) or placebo oil every 12 h. Each treatment lasted for 4 weeks with a 2-week washout period. Baseline veterinary assessment and owner questionnaires were completed before initiating each treatment and at weeks 2 and 4. Hematology, serum chemistry and physical examinations were performed at each visit. A mixed model analysis, analyzing the change from enrollment baseline for all other time points was utilized for all variables of interest, with a p ≤ 0.05 defined as significant. Results: Pharmacokinetics revealed an elimination half-life of 4.2 h at both doses and no observable side effects. Clinically, canine brief pain inventory and Hudson activity scores showed a significant decrease in pain and increase in activity (p < 0.01) with CBD oil. Veterinary assessment showed decreased pain during CBD treatment (p < 0.02). No side effects were reported by owners, however, serum chemistry showed an increase in alkaline phosphatase during CBD treatment (p < 0.01). Clinical significance: This pharmacokinetic and clinical study suggests that 2 mg/kg of CBD twice daily can help increase comfort and activity in dogs with OA.

Keywords: CBD oil; canine; cannabidiol; hemp; osteoarthritis; pharmacokinetic.

Source: https://pubmed.ncbi.nlm.nih.gov/30083539/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1TUbR4JfRTv1rbahLd1HaiF0w5ryO5ocWB3_xk3Prq78L0AEhI&fc=20200804222312&ff=20200815235258&v=2.11.5

Heartland

Need to get some cbd seeds for outdoor growing, any recommendations?

Republished by Plato

Published

on

Visit our community site for vetted suppliers at http://theCBD.place. It’s time that this subject was given more internet exposure. We are here to discuss topics related to medical marijuana and our experiences using CBD. Please do not assume that anyone here is a medical professional.

Coinsmart. Beste Bitcoin-Börse in Europa
Source: https://www.reddit.com/r/CBD/comments/mrvfhj/need_to_get_some_cbd_seeds_for_outdoor_growing/

Continue Reading

Heartland

Love Hemp in UK got the top CBD award if your looking for good CBD

Republished by Plato

Published

on

Visit our community site for vetted suppliers at http://theCBD.place. It’s time that this subject was given more internet exposure. We are here to discuss topics related to medical marijuana and our experiences using CBD. Please do not assume that anyone here is a medical professional.

Coinsmart. Beste Bitcoin-Börse in Europa
Source: https://www.reddit.com/r/CBD/comments/mrvcwh/love_hemp_in_uk_got_the_top_cbd_award_if_your/

Continue Reading

Heartland

Will CBD help appetite?

Republished by Plato

Published

on

Visit our community site for vetted suppliers at http://theCBD.place. It’s time that this subject was given more internet exposure. We are here to discuss topics related to medical marijuana and our experiences using CBD. Please do not assume that anyone here is a medical professional.

Coinsmart. Beste Bitcoin-Börse in Europa
Source: https://www.reddit.com/r/CBD/comments/mrv114/will_cbd_help_appetite/

Continue Reading
Uncategorized4 days ago

Halo Collective Announces New Appointment to Board of Directors and Completes Securities Issuance to Independent Consultants, Related Parties, and Suppliers

Metal4 days ago

Registration open for IHEA annual meeting

Heartland2 days ago

Real Brands Inc. CEO Discusses Corporate Goals and Resolve in Audio Interview with …

Heartland4 days ago

Asia Pacific IoT command centre to be established in Adelaide

Heartland2 days ago

Harvard Study Finds Cannabis Effective for Chronic Pain

Heartland1 day ago

First time with WNC or any Indoor CBD in general.

Heartland4 days ago

does cbd help with dizziness?

Heartland1 day ago

Any sales for goin on ?

Heartland2 days ago

I just bought this brand that I have never seen before. Has anyone ever heard of it?

Heartland3 days ago

Are Delta-8 THC Syringes the Most Practical Way to Medicate?

Heartland20 hours ago

At Virtual Forum, Wisconsin Gov. Tony Evers Calls on Lawmakers to Legalize Cannabis

Heartland5 days ago

Heartland5 days ago

Heartland5 days ago

Heartland4 days ago

Heartland4 days ago

Heartland8 hours ago

The future of the cannabis industry and sports

Heartland5 days ago

Heartland4 days ago

Auckland CBD shop among newest locations of interest for Covid-positive border worker

Heartland4 days ago

Heartland3 days ago

Heartland2 days ago

Heartland4 days ago

Heartland4 days ago

Heartland4 days ago

Heartland4 days ago

Heartland4 days ago

Northeast Regulators Talk Cannabis, Real Estate, and Regional Collaboration

Heartland5 days ago

Do you have a favorite CBD product?

News5 days ago

Get Ready for Some Volatility

Heartland4 days ago

Are there usually deals on 4/20? Especially at WNC.

Trending

A Cloud Nine Capital Entity Copyright © 2020 – All Rights Reserved Proudly Made in America