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Pharmacokinetics of oral and intravenous cannabidiol and its antidepressant-like effects in chronic mild stress mouse model

Cannabidiol (CBD) exhibits significant efficacy in mental and inflammatory diseases. Several studies have recently reported on the rapid antidepressant-like effects of CBD, suggesting that CBD is a potential anti-depressant or anti-stress drug. However, CBD is mainly administered orally or by inhalation with poor bioavailability, resulting in high costs. We aim to explore the efficacy of long-term periodic administration of CBD in chronic mild stress (CMS) via two routes and its…

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Cannabidiol (CBD) exhibits significant efficacy in mental and inflammatory diseases. Several studies have recently reported on the rapid antidepressant-like effects of CBD, suggesting that CBD is a potential anti-depressant or anti-stress drug. However, CBD is mainly administered orally or by inhalation with poor bioavailability, resulting in high costs. We aim to explore the efficacy of long-term periodic administration of CBD in chronic mild stress (CMS) via two routes and its pharmacokinetics. We treated ICR mice with CBD administered orally and intravenously and then determined the kinetic constants. A single bolus intravenous injection of CBD resulted in a half-life of 3.9 h, mean residence time of 3.3 h, and oral bioavailability of about 8.6%. The antidepressant-like effects of periodically administered CBD on the chronic mild stress mouse model are evaluated. Results demonstrated that such treatment at a high dose of 100 mg/kg CBD (p.o.) or a low dose of 10 mg/kg CBD (i.v.), elicited significant antidepressant-like behavioral effects in forced swim test, following increased mRNA expression of brain-derived neurotrophic factor (BDNF) and synaptophysin in the prefrontal cortex and the hippocampus. Our findings are expected to provide a reference for the development of intravenous antidepressant formulations of CBD.

Keywords: CBD; CMS; Cannabidiol; Depression; Pharmacokinetics.

Source: https://pubmed.ncbi.nlm.nih.gov/31173966/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1TQbL92JdzYTve0m3OsSoggMby2JyZDVBLRHiDMYZkT1hs6YNQ&fc=20200804223051&ff=20200815202906&v=2.11.5

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My Mom Is In A Lot Of Pain. So Much Nerve Damage They Had To Remove 3 Disks In Her Neck. Assistance On CBD And Med Interactions, Please!

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My mom is taking Januvia, Glipizide, Lantus Injections, and Trulicity Injections. I really think gummies with CBD:THC 100:1 would really help her. Unfortunately, I have heard that diabetes medications might interfere with CBD and vice versa. Does anyone have any experience with interactions with these medications? None of her prescriptions have the grapefruit warning on the labels.

Edited to make corrections.

Source: https://www.reddit.com/r/CBD/comments/l23ooi/my_mom_is_in_a_lot_of_pain_so_much_nerve_damage/

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MP Trae el Flow del Año 3000: Su Papel en Red Bull, Su Anhelo de FMS y su Tema con Kódigo

ElPlanteo.com entrevista al freestyler y músico MP, también conocido como “El Juvenil”. Nacido en 1999 su nombre viene, según dice, de que se ve muy joven en escena.

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MP Trae el Flow del Año 3000: Su Papel en Red Bull, Su Anhelo de FMS y su Tema con Kódigo | High Times





























Source: https://hightimes.com/espanol/mp-trae-el-flow-del-ano-3000-su-papel-en-red-bull-su-anhelo-de-fms-y-su-tema-con-kodigo/

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Bert Kreischer on Comedy Shows During COVID And Hanging Out With Snoop Dogg

Comedian Bert Kreisher is a “go big or go home” type of man.

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Bert Kreischer on Comedy Shows During COVID And Hanging Out With Snoop Dogg | High Times






























Source: https://hightimes.com/celebrities/bert-kreischer-comedy-shows-during-covid-hanging-out-with-snoop-dogg/

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