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Pharmacokinetics of Bedrocan®, a cannabis oil extract, in fasting and fed dogs: An explorative study

The aim of this study was to explore the pharmacokinetics of the two main active compounds (THC and CBD) contained in the cannabis oil extract Bedrocan® in fasting and fed dogs. Bedrocan® (20% delta-9-tetrahydrocannabinol [THC] and 0.5% cannabidiol [CBD]) was administered at 1.5 and 0.037 mg/kg THC and CBD, respectively in fasted and fed dogs according to a 2 × 2 cross over study design. The quantification of the two active ingredients was performed by LC/MS. No detectable concentrations of CDB…

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. 2019 Apr;123:26-28.

doi: 10.1016/j.rvsc.2018.12.003. Epub 2018 Dec 17.

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Beata Łebkowska-Wieruszewska et al. Res Vet Sci. .

Abstract

The aim of this study was to explore the pharmacokinetics of the two main active compounds (THC and CBD) contained in the cannabis oil extract Bedrocan® in fasting and fed dogs. Bedrocan® (20% delta-9-tetrahydrocannabinol [THC] and 0.5% cannabidiol [CBD]) was administered at 1.5 and 0.037 mg/kg THC and CBD, respectively in fasted and fed dogs according to a 2 × 2 cross over study design. The quantification of the two active ingredients was performed by LC/MS. No detectable concentrations of CDB were found at any collection time. THC was quantifiable from 0.5 to 10 h, although there was large inter-subject variability. Fed dogs showed a longer absorption phase (Tmax 5 vs 1.25 h) and lower maximal blood concentration (7.1 vs 24 ng/mL) compared with the fasted group. A larger AUC was found in the fasted group; the relative oral bioavailability in fed animals was 48.22%.

Keywords: Bedrocan®; Cannabis oil extract; Dogs; Food; Medical marijuana.

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Source: https://pubmed.ncbi.nlm.nih.gov/30580232/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1TUbR4JfRTv1rbahLd1HaiF0w5ryO5ocWB3_xk3Prq78L0AEhI&fc=20200804222312&ff=20200815235258&v=2.11.5

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Questions about AVD carts

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I’m relatively new to CBD and i’ve just gotten my order from hemp barn and i was surprised to see i receieved an avd cart rather than a ccell my questions are:

  1. is avd better than ccells?

  2. What voltage should I run avd carts at? It hits weaker than my last cart

  3. Is my avd disposable cart refillable?

Source: https://www.reddit.com/r/CBD/comments/jlpa2v/questions_about_avd_carts/

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Heartland

Trump’s Department of Justice Is Harassing Legal Weed Companies Because Bill Barr Hates Pot

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A DOJ whistleblower says that because of Barr’s personal antipathy toward cannabis, the department is deliberately harassing legal cannabis companies with pointless investigations. The top brass around Barr knows that these probes are absolutely bogus.

Source: https://www.reddit.com/r/CBD/comments/jlp467/trumps_department_of_justice_is_harassing_legal/

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CBD, Abilify? Will it interact with 2.5mg a day

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My doc is ant-cannabis she sees no medicinal value in cannabis. I don’t smoke weed and that’s the only med I’m taking. Thought maybe some other people in a similar situation could give me some info. I know it’s metabolised by the same enzyme I don’t want a build up of Abilify although with a so low dose does it matter is my question?

Source: https://www.reddit.com/r/CBD/comments/jlogep/cbd_abilify_will_it_interact_with_25mg_a_day/

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