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Oral cannabinoids in people living with HIV on effective antiretroviral therapy: CTN PT028-study protocol for a pilot randomised trial to assess safety, tolerability and effect on immune activation

INTRODUCTION: Despite antiretroviral therapy (ART), people living with HIV have higher rates of non-infectious chronic diseases. These conditions are driven by relatively high levels of inflammation persisting on ART compared with uninfected individuals. Chronic inflammation also contributes to HIV persistence during ART. Cannabis when taken orally may represent a way to reduce inflammation and strengthen immune responses. Before planning large interventional studies, it is important to ensure…

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Introduction: Despite antiretroviral therapy (ART), people living with HIV have higher rates of non-infectious chronic diseases. These conditions are driven by relatively high levels of inflammation persisting on ART compared with uninfected individuals. Chronic inflammation also contributes to HIV persistence during ART. Cannabis when taken orally may represent a way to reduce inflammation and strengthen immune responses. Before planning large interventional studies, it is important to ensure that cannabis taken orally is safe and well tolerated in people living with HIV. We propose to conduct a pilot randomised trial to examine the safety and tolerability of cannabis oils containing tetrahydrocannabinol (THC) and cannabidiol (CBD) consumed orally in people living with HIV. We will also measure inflammatory markers, markers of HIV persistence in peripheral blood cells and changes in the gastrointestinal microbiome.

Methods and analysis: Twenty-six people living with HIV having undetectable viral load for at least 3 years will be randomised to receive TN-TC11LM (THC:CBD in 1:1 ratio) or TN-TC19LM (THC:CBD in 1:9 ratio) capsules daily for 12 weeks. Safety and tolerability of these capsules will be assessed through haematological, hepatic and renal blood tests, face-to-face interviews and questionnaires. Proportions of participants without any signs of significant toxicity (grades 0-2 scores on the WHO toxicity scale) and who complete the study, as well as scores on quality of life and mood will be examined using descriptive statistics. The effects on inflammatory markers, markers of peripheral blood reservoir size and effect on the composition of the gastrointestinal microbiome will be assessed before and after study completion.

Ethics and dissemination: This study has been approved by the Research Institute of the McGill University Health Centre. A Data Safety Monitor will review safety information at regular intervals. The final manuscript will be submitted to an open-access journal within 6 months of study completion.

Trial registration number: NCT03550352.

Keywords: HIV reservoir; cannabinoids; cannabis; immune activation; inflammation; safety and tolerability.

Source: https://pubmed.ncbi.nlm.nih.gov/30659041/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1TQbL92JdzYTve0m3OsSoggMby2JyZDVBLRHiDMYZkT1hs6YNQ&fc=20200804223051&ff=20200825002725&v=2.11.5

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My experience with CBD

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I will not spend an hour summarizing my mental health. I will just say that for years I have been plagued by depression, anxiety, antisocial feelings, and over the past year or so a feeling of brain fog. I was diagnosed with ADD as a child and they decided I didn’t have it 2 years later but I know I likely still do. I decided to finally give CBD from the local Rite aid a try. After 4 days I can say that the brain fog is gone. A week ago I couldn’t even explain the feeling that plagued me. I still don’t feel anything close to a normal person but I can say that I have a better ability to process my brain that I haven’t felt in years. I reccomend anyone who is interested give CBD a try. I only hope the clowns in our country can get past the marijuana BS that they try to strong along and connect to CBD.

Source: https://www.reddit.com/r/CBD/comments/jlasaf/my_experience_with_cbd/

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Anyone tried 10DollarCartridge CBD carts?

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Visit our community site for vetted suppliers at http://theCBD.place. It’s time that this subject was given more internet exposure. We are here to discuss topics related to medical marijuana and our experiences using CBD. Please do not assume that anyone here is a medical professional.

Source: https://www.reddit.com/r/CBD/comments/jl95ga/anyone_tried_10dollarcartridge_cbd_carts/

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Anxiety and ADD?

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I went to a doctor to try and sort out my anxiety issues, they are becoming a bit much to self manage. They put me on Prozac and it was a complete nightmare, the side effects were horrible, not to mention all of the unspoken rules that came along with it, no drinking, no ibuprofen, and countless others.

I am a regular THC user and that seems to help control my anxiety in the evenings but I obviously do not use at work which is where the problem lies.

I have issues with general anxiety, social anxiety, and add. Can CBD help me? How do I know how much to take, and do I have to keep taking it as in does it wear off ever couple hours? I dont know anything about this stuff but I know that Prozac is NOT for me!!!

Source: https://www.reddit.com/r/CBD/comments/jl7gfk/anxiety_and_add/

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