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O-Methyl Phytocannabinoids: Semi-synthesis, Analysis in Cannabis Flowerheads, and Biological Activity

Published

2 years ago

April 2, 2019

Republished by Plato

. 2019 Aug;85(11-12):981-986.

doi: 10.1055/a-0883-5383. Epub 2019 Apr 1.

Affiliations

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Diego Caprioglio et al. Planta Med. 2019 Aug.

. 2019 Aug;85(11-12):981-986.

doi: 10.1055/a-0883-5383. Epub 2019 Apr 1.

Affiliations

¹ Dipartimento di Scienze del Farmaco, Università del Piemonte Orientale, Novara, Italy.
² Dipartimento di Farmacia, Università di Napoli Federico II, Napoli, Italy.
³ Maimonides Biomedical Research Institute of Córdoba; Department of Cellular Biology, Physiology and Immunology, University of Córdoba; University Hospital Reina Sofía, Córdoba, Spain.

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Abstract

A general protocol for the selective mono-O-methylation of resorcinyl phytocannabinoids was developed. The availability of semisynthetic monomethyl analogues of cannabigerol, cannabidiol, and cannabidivarin (1A: -3A: , respectively) made it possible to quantify these minor phytocannabinoids in about 40 different chemotypes of fiber hemp. No chemotype significantly accumulated mono-O-methyl cannabidiol (2B: ) or its lower homologue (3B: ), while at least three chemotypes containing consistent amounts (≥ 400 mg/kg) of O-methylcannabigerol (1B: ) were identified. O-Methylation of alkyl phytocannabinoids (1B: -3B: ) does not significantly change the activity on peroxisome proliferator-activated receptors in contrast to what was reported for phenethyl analogues.

Georg Thieme Verlag KG Stuttgart · New York.

Conflict of interest statement

The authors declare no conflict of interest.

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Source: https://pubmed.ncbi.nlm.nih.gov/30934093/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=18gXB4q-CV5o0kQDSCt3HqwNcsXbn1PxqekJlWJaIbT8zAG16G&fc=20200804213200&ff=20200814034525&v=2.11.5

Related Topics:activity analysis cannabinoid cannabis heartland hemp protocol research search

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