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Neuroprotective and Neuromodulatory Effects Induced by Cannabidiol and Cannabigerol in Rat Hypo-E22 cells and Isolated Hypothalamus

CONCLUSION: The CBD modulates hypothalamic neuromodulators consistently with its anorexigenic role, whereas the CBG effect on the same mediators suggests alternative mechanisms, possibly involving peripheral pathways.

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Background: Cannabidiol (CBD) and cannabigerol (CBG) are non-psychotropic terpenophenols isolated from Cannabis sativa, which, besides their anti-inflammatory/antioxidant effects, are able to inhibit, the first, and to stimulate, the second, the appetite although there are no studies elucidating their role in the hypothalamic appetite-regulating network. Consequently, the aim of the present research is to investigate the role of CBD and CBG in regulating hypothalamic neuromodulators. Comparative evaluations between oxidative stress and food intake-modulating mediators were also performed.

Methods: Rat hypothalamic Hypo-E22 cells and isolated tissues were exposed to either CBD or CBG, and the gene expressions of neuropeptide (NP)Y, pro-opiomelanocortin (POMC) and fatty acid amide hydrolase were assessed. In parallel, the influence of CBD on the synthesis and release of dopamine (DA), norepinephrine (NE), and serotonin (5-HT) was evaluated. The 3-hydroxykinurenine/kinurenic acid (3-HK/KA) ratio was also determined.

Results: Both CBD and CBG inhibited NPY and POMC gene expression and decreased the 3-HK/KA ratio in the hypothalamus. The same compounds also reduced hypothalamic NE synthesis and DA release, whereas the sole CBD inhibited 5-HT synthesis.

Conclusion: The CBD modulates hypothalamic neuromodulators consistently with its anorexigenic role, whereas the CBG effect on the same mediators suggests alternative mechanisms, possibly involving peripheral pathways.

Keywords: cannabidiol; cannabigerol; hypothalamus; kinurenine pathway; neuropeptide; neurotransmitter.

Source: https://pubmed.ncbi.nlm.nih.gov/31941059/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1TQbL92JdzYTve0m3OsSoggMby2JyZDVBLRHiDMYZkT1hs6YNQ&fc=20200804223051&ff=20200813025731&v=2.11.5

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Looking for something to help with my…everything

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I have a laundry list of conditions, both physical and mental. I am looking at a few different types of CBD, namely vape juices and flowers. I am looking for strains that help with anxiety, depression, insomnia, PTSD, mood swings, and nerve and joint pain. I take medication for all of these things, but these conditions still plague my life. Are there any specific strains or flowers I should be looking at?

Source: https://www.reddit.com/r/CBD/comments/l4icle/looking_for_something_to_help_with_myeverything/

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Recipes for making CBD Flower into gummies?

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My wife uses the CBD flower and I was thinking about making her flower into gummies. A friend of her gave her 2 ounces of flower, but that’s way too much for her to use before it goes bad. I tried googling some stuff but it’s all pretty confusing and it was like factory production of CBD. Any info this group may have will be very helpful!

Source: https://www.reddit.com/r/CBD/comments/l4gnwh/recipes_for_making_cbd_flower_into_gummies/

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New T5 strain from Roots and Herb Farm

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Visit our community site for vetted suppliers at http://theCBD.place. It’s time that this subject was given more internet exposure. We are here to discuss topics related to medical marijuana and our experiences using CBD. Please do not assume that anyone here is a medical professional.

Source: https://www.reddit.com/r/CBD/comments/l4gjgf/new_t5_strain_from_roots_and_herb_farm/

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