Connect with us

Heartland

Molecular mechanisms of maternal cannabis and cigarette use on human neurodevelopment

Prenatal development is highly sensitive to maternal drug use due to the vulnerability for disruption of the fetal brain with its ongoing neurodevelopment, resulting in lifelong consequences that can enhance risk for psychiatric disorders. Cannabis and cigarettes are the most commonly used illicit and licit substances, respectively, among pregnant women. Although the behavioral consequences of prenatal cannabis and cigarette exposure have been well-documented in epidemiological and clinical…

Republished by Plato

Published

on

Figure 2. Mesolimbic dopamine D2R gene is vulnerable to prenatal cannabis exposure

Prenatal cannabis affects dopamine D2R gene expression in the nucleus accumbens of the human midgestational fetus exposed to cannabis in utero. The effects are mimicked in the prenatal THC animal model studied at postnatal day 2 (PND2; comparable to the midgestation human fetal period) and the early developmental disturbances on the Drd2 mRNA expression persist into adulthood (PND62) and are mediated by epigenetic modifications at the Drd2 promoter. Data modified from (Dinieri et al., 2011) 2meH3K9, di-methylation of lysine 9 on histone H3; 3meH3K4, tri-methylation of lysine 4 on histone H3; KB, kilobases; RNA Poly II, RNA Polymerase II; TSS, transcription start site. Values are expressed as mean ± SEM. *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001 vs control subjects. Black bars, THC exposed group; white bars, vehicle-exposed group; kb, kilobases; TSS, transcription start site.

Source: https://pubmed.ncbi.nlm.nih.gov/22103415/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1z7zlNEMzQex5jriqkhCblNtckSEpT9xYlxxeymU_73UTETESY&fc=20200804213258&ff=20200811231053&v=2.11.5

Heartland

Republished by Plato

Published

on

Coinsmart. Beste Bitcoin-Börse in Europa
Source:

Continue Reading

Heartland

Republished by Plato

Published

on

Coinsmart. Beste Bitcoin-Börse in Europa
Source:

Continue Reading

Heartland

Republished by Plato

Published

on

Coinsmart. Beste Bitcoin-Börse in Europa
Source:

Continue Reading
Uncategorized4 days ago

Halo Collective Announces New Appointment to Board of Directors and Completes Securities Issuance to Independent Consultants, Related Parties, and Suppliers

Metal4 days ago

Registration open for IHEA annual meeting

Heartland2 days ago

Real Brands Inc. CEO Discusses Corporate Goals and Resolve in Audio Interview with …

Heartland4 days ago

Asia Pacific IoT command centre to be established in Adelaide

Heartland2 days ago

Harvard Study Finds Cannabis Effective for Chronic Pain

Heartland1 day ago

First time with WNC or any Indoor CBD in general.

Heartland4 days ago

does cbd help with dizziness?

Heartland1 day ago

Any sales for goin on ?

Heartland2 days ago

I just bought this brand that I have never seen before. Has anyone ever heard of it?

Heartland3 days ago

Are Delta-8 THC Syringes the Most Practical Way to Medicate?

Heartland22 hours ago

At Virtual Forum, Wisconsin Gov. Tony Evers Calls on Lawmakers to Legalize Cannabis

Heartland11 hours ago

The future of the cannabis industry and sports

Heartland5 days ago

Heartland5 days ago

Heartland5 days ago

Heartland4 days ago

Heartland4 days ago

Heartland4 days ago

Heartland3 days ago

Heartland4 days ago

Heartland4 days ago

Auckland CBD shop among newest locations of interest for Covid-positive border worker

Heartland4 days ago

Heartland4 days ago

Heartland2 days ago

Heartland4 days ago

Heartland4 days ago

Northeast Regulators Talk Cannabis, Real Estate, and Regional Collaboration

Heartland5 days ago

Do you have a favorite CBD product?

News5 days ago

Get Ready for Some Volatility

Heartland4 days ago

Are there usually deals on 4/20? Especially at WNC.

Heartland4 days ago

What’s the best flower in EU? (<0.2% THC)

Trending

A Cloud Nine Capital Entity Copyright © 2020 – All Rights Reserved Proudly Made in America