Heartland

Molecular mechanisms of maternal cannabis and cigarette use on human neurodevelopment

Prenatal development is highly sensitive to maternal drug use due to the vulnerability for disruption of the fetal brain with its ongoing neurodevelopment, resulting in lifelong consequences that can enhance risk for psychiatric disorders. Cannabis and cigarettes are the most commonly used illicit and licit substances, respectively, among pregnant women. Although the behavioral consequences of prenatal cannabis and cigarette exposure have been well-documented in epidemiological and clinical…

Published

9 years ago

November 23, 2011

Republished by Plato

Figure 2. Mesolimbic dopamine D₂R gene is vulnerable to prenatal cannabis exposure

Prenatal cannabis affects dopamine D₂R gene expression in the nucleus accumbens of the human midgestational fetus exposed to cannabis in utero. The effects are mimicked in the prenatal THC animal model studied at postnatal day 2 (PND2; comparable to the midgestation human fetal period) and the early developmental disturbances on the Drd2 mRNA expression persist into adulthood (PND62) and are mediated by epigenetic modifications at the Drd2 promoter. Data modified from (Dinieri et al., 2011) 2meH3K9, di-methylation of lysine 9 on histone H3; 3meH3K4, tri-methylation of lysine 4 on histone H3; KB, kilobases; RNA Poly II, RNA Polymerase II; TSS, transcription start site. Values are expressed as mean ± SEM. *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001 vs control subjects. Black bars, THC exposed group; white bars, vehicle-exposed group; kb, kilobases; TSS, transcription start site.

Source: https://pubmed.ncbi.nlm.nih.gov/22103415/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1z7zlNEMzQex5jriqkhCblNtckSEpT9xYlxxeymU_73UTETESY&fc=20200804213258&ff=20200811231053&v=2.11.5

Related Topics:cannabis Data development heartland risk thc

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Rat models of prenatal and adolescent cannabis exposure

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Industrial hemp seminar held in Chamberlain

Published

1 hour ago

October 24, 2020

Republished by Plato

CHAMBERLAIN, S.D. (KELO) — About a dozen people turned out Saturday for a meeting on industrial hemp in South Dakota.

The event was organized by producers and business people from Nebraska, where some farmers have been producing low-THC hemp.

South Dakota is getting ready to dip its toe into the hemp field. State legislators passed a law this year legalizing hemp with no more than 0.3% THC. The U.S. Department of Agriculture approved South Dakota’s plan October 15. A state rules hearing is set for November 13.

South Dakota Senate Democratic leader Troy Heinert of Mission started working on industrial hemp years ago. He sponsored a bill in 2016 that the House of Representatives passed but died after a Senate committee hearing.

South Dakota lawmakers passed a bill last year but Governor Kristi Noem vetoed it. This year she agreed to sign it.

“I’m sorry we are not as far along as we should be, because we’ve been talking about this for a long time,” Heinert said.

What made the difference, he said, was that several tribal governments in South Dakota received USDA approval for their plans. They needed to be able to transport hemp outside their reservations.

“Tribes were now allowed to grow hemp,” said Heinert, a member of the Rosebud Sioux Tribe. “That changed things.”

He noted that South Dakota is only state in the nation where ingestion and possession of marijuana are felony crimes.

Another speaker Saturday was Katie Sieverding. She is executive director for the South Dakota Industrial Hemp Association. Sieverding said the federal government wants modifications to South Dakota’s new law. She said the Noem administration is expected to bring a lengthy bill for the 2021 legislative session.

Ken Meyer, from Winfred-based A.H. Meyer and Sons, said the company plans to use CO2 to produce CBD oil after it receives a South Dakota hemp-processor license. The company currently specializes in rendering and selling beeswax to honey producers.

Adam Brewer founded CBD Remedies in Lincoln, Nebraska. The company focuses on retail sales and also manufactures products. Brewer said packaging that includes THC data is important for consumer confidence.

Derek Kats, who started Hemp Consultants in Lincoln, Nebraska, three years ago, said Nebraska is “very behind” in its processing for industrial hemp. “The cultivation side is key, but unless all these other pieces are put in place, the cultivation bottle-necks,” Kats said.

Source: https://www.google.com/url?rct=j&sa=t&url=https://www.keloland.com/news/capitol-news-bureau/industrial-hemp-seminar-held-in-chamberlain/&ct=ga&cd=CAIyGjYxZmRhODRmNjY4MjhhNTU6Y29tOmVuOlVT&usg=AFQjCNGa2DXqilXAUH6NHJMLp2Owxao7OQ

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Tryplainjane 1000 mg CBD Full Spectrum Oil $29 Legit or Scam?

Published

1 hour ago

October 24, 2020

Republished by Plato

I have no info on this brand. Tbh that is the price is closer to what we all should be paying for cbd. Most companies use $10 worth of cbd isolate, slap a fancy label, and maybe a dash of full spectrum and charge $100 for it. I started making my own cbd/cbg/cbn oils. Veteran grown has great prices on cbd isolate. Industrial hemp farms has the best prices on cbd cbg and cbn. 1 gram of isolate is 990 mg of cbd. Put it in warm coconut oil. Stir until dissolved and poof you have cbd oil. ✌🏻💚🌳

Edit: this is why I layer my cannaboids https://www.chiroeco.com/entourage-cbd/amp/

Source: https://www.reddit.com/r/CBD/comments/jhfjwh/tryplainjane_1000_mg_cbd_full_spectrum_oil_29/

Heartland

Couple grams of full spectrum wax, gonna be a nice night :)

Published

2 hours ago

October 24, 2020

Republished by Plato

Visit our community site for vetted suppliers at http://theCBD.place. It’s time that this subject was given more internet exposure. We are here to discuss topics related to medical marijuana and our experiences using CBD. Please do not assume that anyone here is a medical professional.

Source: https://www.reddit.com/r/CBD/comments/jhf3ch/couple_grams_of_full_spectrum_wax_gonna_be_a_nice/