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Medicinal cannabis for psychiatric disorders: a clinically-focused systematic review

CONCLUSIONS: There is currently encouraging, albeit embryonic, evidence for medicinal cannabis in the treatment of a range of psychiatric disorders. Supportive findings are emerging for some key isolates, however, clinicians need to be mindful of a range of prescriptive and occupational safety considerations, especially if initiating higher dose THC formulas.

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Background: Medicinal cannabis has received increased research attention over recent years due to loosening global regulatory changes. Medicinal cannabis has been reported to have potential efficacy in reducing pain, muscle spasticity, chemotherapy-induced nausea and vomiting, and intractable childhood epilepsy. Yet its potential application in the field of psychiatry is lesser known.

Methods: The first clinically-focused systematic review on the emerging medical application of cannabis across all major psychiatric disorders was conducted. Current evidence regarding whole plant formulations and plant-derived cannabinoid isolates in mood, anxiety, sleep, psychotic disorders and attention deficit/hyperactivity disorder (ADHD) is discussed; while also detailing clinical prescription considerations (including pharmacogenomics), occupational and public health elements, and future research recommendations. The systematic review of the literature was conducted during 2019, assessing the data from all case studies and clinical trials involving medicinal cannabis or plant-derived isolates for all major psychiatric disorders (neurological conditions and pain were omitted).

Results: The present evidence in the emerging field of cannabinoid therapeutics in psychiatry is nascent, and thereby it is currently premature to recommend cannabinoid-based interventions. Isolated positive studies have, however, revealed tentative support for cannabinoids (namely cannabidiol; CBD) for reducing social anxiety; with mixed (mainly positive) evidence for adjunctive use in schizophrenia. Case studies suggest that medicinal cannabis may be beneficial for improving sleep and post-traumatic stress disorder, however evidence is currently weak. Preliminary research findings indicate no benefit for depression from high delta-9 tetrahydrocannabinol (THC) therapeutics, or for CBD in mania. One isolated study indicates some potential efficacy for an oral cannabinoid/terpene combination in ADHD. Clinical prescriptive consideration involves caution in the use of high-THC formulations (avoidance in youth, and in people with anxiety or psychotic disorders), gradual titration, regular assessment, and caution in cardiovascular and respiratory disorders, pregnancy and breast-feeding.

Conclusions: There is currently encouraging, albeit embryonic, evidence for medicinal cannabis in the treatment of a range of psychiatric disorders. Supportive findings are emerging for some key isolates, however, clinicians need to be mindful of a range of prescriptive and occupational safety considerations, especially if initiating higher dose THC formulas.

Keywords: CBD; Cannabidiol; Cannabinoids; Cannabis; Marijuana; Medicinal plants; Mental health; Pharmacogenomics; THC.

Source: https://pubmed.ncbi.nlm.nih.gov/31948424/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1LgINZmdEb7hTii13TOa5DGOR2cvkVQ2sw4N7-xSaEiod6ucE1&fc=20200804221722&ff=20200811031935&v=2.11.5

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5 Reasons To Incorporate CBD Into Your life

Cannabidiol, also known as CBD, is at the forefront of hemp-derived products – and for a good reason. The mild effects of brain cognition help users after a stressful day with relaxation and other subtle mind-altering effects. Contrary to the conventional THC, CBD is a popular alternative due to its safer neuroprotective properties – that […]

The post 5 Reasons To Incorporate CBD Into Your life appeared first on Knockout CBD.

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Cannabidiol, also known as CBD, is at the forefront of hemp-derived products – and for a good reason. The mild effects of brain cognition help users after a stressful day with relaxation and other subtle mind-altering effects. Contrary to the conventional THC, CBD is a popular alternative due to its safer neuroprotective properties – that are somewhat more welcoming than THC’s psychoactive effects. While CBD’s different ingestion methods have notes of varying results, the overall usage generates considerable health benefits that make it an appealing consumable. While the option to ingest CBD is ultimately up to your preference, here are our top 5 reasons to incorporate CBD into your life. 

Helps alleviate anxiety

With 3.1% of the US population being affected by anxiety, this problem is very much prominent today. Especially in these trying times, from factors such as career difficulties or emotional strain, the reasons for accumulating stress and anxiety are immeasurable. While not necessarily needing to consult a doctor, common traits of anxiety can include the following: 

  • Difficulty concentrating
  • Difficulty sleeping
  • Irritability 
  • Muscle Tension
  • Sweaty Palms
  • Rapid Heartbeat

Overall, feeling off is contributed by these factors – where we can commonly diagnose ourselves with anxiety, but we shouldn’t feel as if there’s no help out there. We’ve all been there. And we all dread the feeling of not being at the top of our mental health. Luckily for us, the quick cut solution of CBD Capsules is an excellent option for an easily consumable product for mild mind-altering effects to assist with the everyday struggle. 

No THC

Contrary to conventional THC, CBD is a popular alternative as its a relatively safer option. With THC being the primary psychoactive constituent of cannabis, the immediate effects may be overwhelming to the casual user. For many CBD enthusiasts, who prefer being more in control of their brain cognition, CBD’s preference comes down to its more welcoming appeal during a session. The option to choose CBD over THC can come down to the following: 

  • Mild effects
  • Winding down while still being coherent
  • Subtle relaxation 
  • After strenuous muscle activity

With THC popularly ingested through vape products, the CBD Vape Pen alternative suffices well. 

Neuroprotective Properties

Thought to interact with CB1 and CB2 receptors in the central nervous system and peripheral nervous system, CBD helps with neuroprotective properties – as shown with its mild effects. While studies are still in the process, the results of CBD are always there to observe. From the mild mind-altering effects to the easiness on your stomach, these effects make life a little more bearable. When following more or less than 5 reasons to incorporate CBD into your life, we like to constitute this point to high priority – as it’s one of the main reasons CBD enthusiasts utilize this product. If you’re a soon to be CBD enthusiast, the classic CBD tincture is an excellent way to get started. 

Substance Abuse Treatment

A common situation with mind-altering products is just how great it can make you feel. We all have stressful days, and we all need something to make the wind down a little more bearable. However, when we get used to these potent effects and become reliant on them – there might be a problem. As this is subjective to the user, we like to stress responsibility, as our idea of CBD is for its mild effects – that don’t take away from your overall ability. When using CBD, we highly recommend following our CBD dosage chart for a safe experience.  

Helps with Appetite

Aside from the neuroprotective properties, CBD shows to help with appetite. Contrary to the conventional THC, it does not give the munchies but helps alleviate sickness from stress or anxiety. Shown to have anti-inflammatory properties to treat gastrointestinal issues, CBD is a great solution to settle a stomach during or after a meal. A quick cut solution, our CBD gummies are an excellent snack with your meal – that help with ingesting CBD in your daily routine. 

Conclusion

With CBD being at the forefront of trending hemp-derived products, there are more than 5 reasons to incorporate CBD into your life. While we have broken it down to these simple steps, the option to use CBD ultimately comes down to the intensity of your mind-altering effects – that make your life a little more bearable. Whether you prefer the CBD Flowers or the CBD Vape Pen, you can always find your next CBD product at Knockout CBD today. 

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Source: https://knockoutcbd.com/5-reasons-to-incorporate-cbd-into-your-life/

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Is CBD Oil For Horses Safe?

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CBD Oil For Horses Safe

People and pets have complicated relationships. Even though you know that your horse might not understand everything you are saying, you still care about it a lot. Imagine if, out of nowhere, it decided that it was not going to eat at all because of internal pain. 

You would want to do everything in your power to help. One of the best medications that are taking over the world is CBD oil. Now, even though there have not been any studies performed on horses, many online forums, and reports state that it helps significantly in many situations.

Many equestrians have tried administering it, and they saw zero adverse effects. Cannabidiol does not have any side effects in humans, dogs, and cats. All of us fall under the Mammalia family, and we all have an endocannabinoid system. That means that you will not have to think twice about giving a few drops to your equine in the morning and at night. 

What are some of the reasons why you should use it?

Is CBD Oil For Horses Safe? 1

Not a single living organism can escape aging. As time goes by, our bodies start to give out. That is just the way life is. After a horse passes through maturity, it starts to experience inflammation, pain, stress, anxiety, and chronic stiffness. 

All these problems make their quality of life much worse than it used to be. That is why most owners want to help in any way they can. You can’t use CBD oil from online sites like Holistapet as a means to cure all diseases, but it helps with a lot of processes. 

One of them is regulating appetite and metabolism. There is a period in every equine’s life when they simply do not want to eat. There are tons of different causes for that, but without food, there is no energy. We all need energy to keep on living. If you have ever smoked weed, then you know how it feels to get the munchies. 

That is the cannabidiol working and regulating your appetite. It also helps to improve emotional states, and it elevates mood. That is why everyone is happy, and everything is a bit funnier after a few puffs. It also helps the immune system work better. It lubricates the joints and helps with mobility, handles irritated skin efficiently, and promotes better bowel health and digestion. 

Seeing that we have the same endocannabinoid system, all these benefits will get transferred to your riding buddy. If your horse was depressed and unable to eat, then giving them a few drops in the morning and the evening will make a huge difference. You will start to feel as if it’s a completely different animal. 

Is it safe?

Even though there are not any horse-specific studies, all the research that has been conducted on other mammals points to a positive outcome. There are no toxic elements to CBD oils, and they do not cause addiction. Many people think that if you use products that contain cannabidiol, you will get hooked like with alcohol, cigarettes, or drugs. 

But that is simply not true. It is medicine, and even when used in high doses, it can be tolerated. Over the past 20 years of rigorous testing, there have only been a few mild side effects. These include dry mouth and drowsiness. 

The easiest way to handle a dry mouth if it happens to your equine is to give them more water. On the other hand, if they feel sleepy after you provide it to them, that means that you overdid it with the dosage. Always start with a small amount and increase it if you don’t see any results. Follow this link for more info https://www.horsetalk.co.nz/2019/07/01/cannabidiol-cbd-horses/.

The body is a marvel of biological engineering. This includes the ECS. Even if you never give your equine a drop of CBD, they will still have endocannabinoids flowing in their bodies, just like we have them too. This system is responsible for regulating memory, temperature, immune function, mood, inflammation, sleep, digestion, and pain. 

Its primary purpose is to keep mammal bodies in homeostasis. Even if your riding buddy did not show you any adverse signs, they would surely feel better. There is no way for them to say thank you, but that is the truth. 

Source: https://www.google.com/url?rct=j&sa=t&url=https://zobuz.com/is-cbd-oil-for-horses-safe/7780/&ct=ga&cd=CAIyGmM2M2RhZjlmZTVmZDZjMmU6Y29tOmVuOlVT&usg=AFQjCNEMQTqDdU5cG0FIcVufbLkb39pnqA

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Is CBD Oil For Horses Safe?

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Is CBD Oil For Horses Safe? People and pets have complicated relationships. Even though you know that your horse might not understand everything … Source:

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