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Marijuana-Derived Cannabinoids Trigger a CB2/PI3K Axis of Suppression of the Innate Response to Oral Pathogens

Cannabis use is an emergent risk factor for periodontitis, a chronic bacterial-induced disease of the supporting structures of the teeth. However, the mechanisms by which marijuana exposure predisposes to periodontal tissue destruction have yet to be elucidated. Therefore, we examined the influence of physiologically relevant doses of major marijuana-derived phytocannabinoid subtypes (cannabidiol [CBD]; cannabinol [CBN]; and tetrahydrocannabinol [THC], 1.0 μg/ml) on the interactions of three…

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Cannabis use is an emergent risk factor for periodontitis, a chronic bacterial-induced disease of the supporting structures of the teeth. However, the mechanisms by which marijuana exposure predisposes to periodontal tissue destruction have yet to be elucidated. Therefore, we examined the influence of physiologically relevant doses of major marijuana-derived phytocannabinoid subtypes (cannabidiol [CBD]; cannabinol [CBN]; and tetrahydrocannabinol [THC], 1.0 μg/ml) on the interactions of three ultrastructurally variant oral pathogens, Porphyromonas gingivalis, Filifactor alocis, and Treponema denticola with the immune system. CBD, CBN, and THC each suppressed P. gingivalis-induced IL-12 p40, IL-6, IL-8, and TNF release while enhancing the anti-inflammatory cytokine, IL-10, from human innate cells. Similar phenomena were observed in F. alocis- and T. denticola-exposed human monocytes and human gingival keratinocytes. Higher phytocannabinoid doses (≥5.0 μg/ml) compromised innate cell viability and inhibited the growth of P. gingivalis and F. alocis, relative to unexposed bacteria. T. denticola, however, was resistant to all cannabinoid doses tested (up to 10.0 μg/ml). Pharmaceutical inhibition and efficient gene silencing indicated that a common CB2/PI3K axis of immune suppression is triggered by phytocannabinoids in vitro. This pathway does not appear to perpetuate through the canonical GSK3β-dependent cholinergic anti-inflammatory pathway, the predominant endogenous inflammatory control system. In a repetitive, transient oral infection model, CBD also suppressed P. gingivalis-induced innate immune markers in wild-type mice, but not in CB2-/- mice. If such phenomena occur in humans in situ, environmental cannabinoids may enhance periodontitis via direct toxic effects on specific oral bacteria; by compromising innate cell vitality; and/or through a suppressed innate response to periodontal pathogens involving a CB2/PI3K signaling lineage.

Keywords: cannabinoid receptor type 1 and 2 (CB1, CB2); cholinergic anti-inflammatory system; glycogen synthase kinase (GSK3β); inflammation; oral bacteria; periodontitis; phosphatidylinositol 3-phosphate-kinase (PI3K); phytocannabinoid.

Source: https://pubmed.ncbi.nlm.nih.gov/31681262/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1TQbL92JdzYTve0m3OsSoggMby2JyZDVBLRHiDMYZkT1hs6YNQ&fc=20200804223051&ff=20200815003443&v=2.11.5

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My Mom Is In A Lot Of Pain. So Much Nerve Damage They Had To Remove 3 Disks In Her Neck. Assistance On CBD And Med Interactions, Please!

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My mom is taking Januvia, Glipizide, Lantus Injections, and Trulicity Injections. I really think gummies with CBD:THC 100:1 would really help her. Unfortunately, I have heard that diabetes medications might interfere with CBD and vice versa. Does anyone have any experience with interactions with these medications? None of her prescriptions have the grapefruit warning on the labels.

Edited to make corrections.

Source: https://www.reddit.com/r/CBD/comments/l23ooi/my_mom_is_in_a_lot_of_pain_so_much_nerve_damage/

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MP Trae el Flow del Año 3000: Su Papel en Red Bull, Su Anhelo de FMS y su Tema con Kódigo

ElPlanteo.com entrevista al freestyler y músico MP, también conocido como “El Juvenil”. Nacido en 1999 su nombre viene, según dice, de que se ve muy joven en escena.

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MP Trae el Flow del Año 3000: Su Papel en Red Bull, Su Anhelo de FMS y su Tema con Kódigo | High Times





























Source: https://hightimes.com/espanol/mp-trae-el-flow-del-ano-3000-su-papel-en-red-bull-su-anhelo-de-fms-y-su-tema-con-kodigo/

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Bert Kreischer on Comedy Shows During COVID And Hanging Out With Snoop Dogg

Comedian Bert Kreisher is a “go big or go home” type of man.

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Bert Kreischer on Comedy Shows During COVID And Hanging Out With Snoop Dogg | High Times






























Source: https://hightimes.com/celebrities/bert-kreischer-comedy-shows-during-covid-hanging-out-with-snoop-dogg/

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