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Is There Such a Thing As Endocannabinoid Deficiency?

Our knowledge and understanding of the endocannabinoid system (ECS) has grown dramatically in recent years. Despite ongoing research into its regulatory role and possible interactions with cannabinoids, there is one phenomenon that remains unanswered. Read on to find out how a deficiency in endocannabinoids is believed to be an underlying factor in several debilitating diseases. […]

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Our knowledge and understanding of the endocannabinoid system (ECS) has grown dramatically in recent years. Despite ongoing research into its regulatory role and possible interactions with cannabinoids, there is one phenomenon that remains unanswered. Read on to find out how a deficiency in endocannabinoids is believed to be an underlying factor in several debilitating diseases.

The endocannabinoid system

The endocannabinoid system is a series of receptors, chemical compounds, and metabolic enzymes that help keep our biological systems in balance. This state of homeostasis occurs when the body and all its functions operate at their optimal level. However, the endocannabinoid system is not capable of improving our body’s optimal state past its natural limits—to do that, it needs supplemental input. This is where cannabinoids come in.

The cannabinoids found in the Cannabis sativa species (and a handful of other plants) are capable of binding to receptors linked to the ECS. When they do, a wide range of biological effects are possible. Together, the endocannabinoids we produce internally and the cannabinoids we consume externally can be used synergistically to boost the capabilities of our ECS.

Studies have shown that adequate levels of endocannabinoids are necessary to maintain the ECS’s regulatory abilities, so what happens if these levels take a dip? That is the same question that Dr. Ethan Russo, a leading researcher of the ECS, aimed to find out.

Clinical endocannabinoid deficiency, what is it?

In 2004, Dr. Russo outlined a phenomenon that he believed could be a contributing factor to migraines, fibromyalgia, irritable bowel syndrome, and other treatment-resistant conditions. Clinical endocannabinoid deficiency (CECD) is believed to occur when endocannabinoids dip below their normal levels, causing us to suffer from disease as a result—diseases that would normally be kept at bay by the regulatory power of the ECS.

Dr. Russo proposed that in several of the conditions mentioned above, there were similarities in the mechanisms that caused their onset. One observed similarity was a deficiency in anandamide, a crucial endocannabinoid that plays a role in pain management, pleasure, and appetite regulation. At the time, the study was met with a significant degree of scepticism because our understanding of the endocannabinoid system was still in its infancy.

The potential implications of CBD and clinical endocannabinoid deficiency

If Dr. Russo’s theories were conclusively proven to be accurate, then the importance of supplementation with cannabinoids becomes paramount in treating the conditions linked to CECD. CBD would inevitably be a frontrunner for those diagnosed with clinical endocannabinoid deficiency because of its interactions with the endocannabinoid system.

In a 2012 study, CBD was found to inhibit the production of the FAAH enzyme. This interaction is important due to the effect FAAH has on anandamide. Fatty acid amide hydrolase is responsible for breaking down anandamide and preventing the endocannabinoid from sustaining its effect. If we think back to one of the underlying mechanisms associated with CECD, anandamide was a key player. Therefore, CBD’s ability to inhibit FAAH production and encourage higher levels of anandamide could prove essential to improving CECD.

Support for CECD is growing

The only problem with the potential interactions between CBD and CECD is just that: they are only “potential”. The phenomenon of clinical endocannabinoid deficiency has yet to be conclusively proven, and any relationships between cannabinoids and treatments are only suspected at this point. Since the initial exploration of the concept, Dr. Russo has released a second paper with further studies to support his claims.

The review highlights, again, similarities between the mechanisms behind migraines, fibromyalgia, and IBS. However, outside of comparing studies, which all have different variables, there is no single study that has set out to identify CECD. Even though the impact of clinical endocannabinoid deficiency is only suspected at this point, the implications, if proven, are significant. It is for this reason that Dr. Russo continues to explore the concept and solidify his theories.

Source: https://thecbdoilcompany.co.za/is-there-such-a-thing-as-endocannabinoid-deficiency/?utm_source=rss&utm_medium=rss&utm_campaign=is-there-such-a-thing-as-endocannabinoid-deficiency

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Our Guide to the 10 Best CBD Oil for Dogs

Does CBD oil work to calm stressed dogs as well as to relieve their pains? This post helps answer that question.

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Source: https://www.cbdschool.com/best-cbd-oil-for-dogs/?utm_source=rss&utm_medium=rss&utm_campaign=best-cbd-oil-for-dogs

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3 Cannabis-Infused Hot Chocolate Recipes

5 Cannabis-Infused Hot Chocolate Recipes There’s nothing more satisfying than a hot chocolate on a cold day, am I right? Today, we’re getting decadent with 3 Cannabis-Infused Hot Chocolate Recipes. I grew up on hot chocolate. We had bitter-cold winter nights in Canada and living on our tobacco farm, in the middle of nowhere. Hot […]

The post 3 Cannabis-Infused Hot Chocolate Recipes appeared first on Cannadish.

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5 Cannabis-Infused Hot Chocolate Recipes

There’s nothing more satisfying than a hot chocolate on a cold day, am I right? Today, we’re getting decadent with 3 Cannabis-Infused Hot Chocolate Recipes.

I grew up on hot chocolate. We had bitter-cold winter nights in Canada and living on our tobacco farm, in the middle of nowhere.

Hot chocolate was a special treat in my house, especially in a chilly farm-house where the wind howled through the cracks on the doors and windows.

Warming up with a hot cup made everything alright in the world, and that first sip?

Perfection.

Now, as an adult, I can enjoy the same things I did as a child but as you’ll read today, with a decadent Cannabis twist!

Sometimes, just sometimes, it’s fun being an adult!

Often times I play with weed recipes to find something new and today I’m sharing them with you so that the next time you sit down to enjoy a steamy mug, you’ll have plenty of options to keep it interesting.

Keep reading to discover 3 cannabis-infused hot chocolate recipes that’ll leave you wanting more and more!

Getting Started with Your Cannabis-Infused Hot Cocoa

The very first, and arguably the most important, ingredient you will need in order to make and enjoy the marijuana-infused hot chocolate recipes is canna milk.

It’s milk that’s very easy to make, and you’ll want to have enough on hand to make your hot cocoa.

Cannamilk takes a few hours to prepare, but it does keep in the fridge for as long as your milk is fresh.

You could prepare a larger batch and have it ready for the next time you want to enjoy some cannabis hot cocoa or any other yummy edible recipes that call for this ingredient.

If you’re vegan or can’t do dairy, you can substitute the milk with a combo of coconut milk and coconut cream that is full-fat.

How to Make Cannamilk

Cannabis infused milk (cannamilk)

4.67 from 3 votes

Prep Time: 30 minutes

Total Time: 30 minutes

Cuisine: European

Keyword: Cannabis, Milk

Calories: 200kcal

THC: 700mg THC

  • Decarboxylate your weed by spreading your cannabis evenly on an oven tray And coat with aluminum foil.

  • Place in the oven on 240F/115C for 40 minutes, and then let it cool.

  • Grind your cannabis or chop it fine

  • Place 4 cups of whole milk in a pan on low heat. Add cannabis and let simmer on low heat for 60/90 minutes without it ever coming to a boil.

  • Strain through a cheesecloth

  • Let it cool

Calories: 200kcal | Fat: 20g

1. Salty-Sweet Classic Cannabis Hot Cocoa

cannabis-hot-chocolate

Salty & Sa-weet!

0 from 0 votes

Prep Time: 2 minutes

Cook Time: 5 minutes

Course: Drinks

Keyword: hotcocoa

Servings: 2 people

Author: Steph Van De Ven

Cost: 10-20

  • Saucepan

  • Oven

  • Whisk

  • 8  squares of 80%+ dark chocolate
  • 1 tsp Himalayan Salt
  • 1/4 cup Brown Sugar
  • 1/3 cup Boiling Water
  • 1 dash Vanilla extract
  • 1/4 cup half-and-half cream or non-dairy creamer
  • 1/4 cup Cannabis Milk
  • Mix together the sugar, salt, and cocoa powder in a small bowl. Then, in a medium saucepan on medium heat, add your boiling water and squares of dark chocolate. Gently whisk chocolate squares around until they melt.
  • Add in your dry ingredients: the sea salt, brown sugar, and cocoa powder and whisk them with the hot water and melted chocolate.

  • Whisk in your cream and cannamilk. Raise the heat and whisk vigorously until the mixture is steaming but not boiling.

  • Remove the mixture from the heat, stir in your vanilla extract, pour your hot cocoa into a mug and enjoy.

2. Black Cherry Bourbon and Cannabis Hot Cocoa

hot-chocolate-with-canabis

SO Good!

0 from 0 votes

Prep Time: 2 minutes

Cook Time: 5 minutes

Course: Drinks

Keyword: Cannabis Milk

Author: Steph Van De Ven

Cost: 20-25

  • Stove

  • Saucepan

  • Whisk

  • Mixing bowl – small

  • 3 cup milk or a non-dairy milk alternative
  • 1/8 cup  boiling water
  • 1/2 cup Cannabis mlik
  • 8 Squares Dark Chocolate – 75% +
  • 1/4 cup Unsweetened Cocoa Powder
  • 4 oz Black Cherry Bourbon
  • 1/4 cup Brown sugar
  • Combine brown sugar and cocoa powder in a mixing bowl , set aside

  • In your saucepan, add in your boiling water and squares of dark chocolate and the heat to medium. With a whisk, stir the chocolate around until it melts and dissolves into the boiling water. Add in your cocoa powder and brown sugar and continue to whisk.

  • On a low to medium heat, add your milk or non-dairy alternative and your cannamilk. Whisk vigorously until the mixture is steaming but not boiling.

  • Take the saucepan away from the heat and set it aside. Add 1 oz. of the bourbon into every cup that you intend to serve hot chocolate with.

  • Enjoy!

3. Nutella Cannabis Hot Cocoa

weed-hot-chocolate

Hazelnut Heaven!

0 from 0 votes

Prep Time: 2 minutes

Cook Time: 5 minutes

Course: Drinks

Keyword: Cannabis Milk

Servings: 24 people

Cost: 10-15

  • Stove

  • Saucepan

  • Whisk

  • Small Mixing Bowl

  • Spoon

  • 3 cups Milk
  • 1/2 cup Cannabis Milk
  • 6-8 tbsp Nutella Depends on your love of Nutella!
  • 1 handful Marshmallows Garnish
  • 1 Dollop Whipped cream Load it up!
  • 1 bottle Chocolate Syrup to drizzle on top
  • 1/2 cup Choped hazelnuts to sprinkle on top
  • In a medium saucepan, combine milk or a non-dairy alternative, cannamilk, and Nutella. Set the stove on medium heat and whisk vigorously until the liquid is steaming and hot but not boiling. Once it reaches this point, remove from the heat.

  • Pour the hot cocoa in mugs and top the cups off with whipped cream, marshmallows, chocolate syrup drizzle and hazelnuts for an added garnish.

If you’re starting to cook with Cannabis, or you are a seasoned Canna-Chef, check out more recipes here.

For great ideas, pairings and cooking products, check out these products.

Source: https://www.cannadish.net/3-cannabis-infused-hot-chocolate-recipes/

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Is M&A Going To Heat Up In The Cannabis Sector With U.S. Federal Legalization Right Around The Corner?

During the last few years, there has been increased consolidation in the cannabis industry and we have identified trends over the course of this time period. The first wave of acquisitions started in Canada and this trend lasted several years. This wave of acquisitions still ranks as some of the most expensive transactions and was […]

The post Is M&A Going To Heat Up In The Cannabis Sector With U.S. Federal Legalization Right Around The Corner? appeared first on Technical420.

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During the last few years, there has been increased consolidation in the cannabis industry and we have identified trends over the course of this time period.

The first wave of acquisitions started in Canada and this trend lasted several years. This wave of acquisitions still ranks as some of the most expensive transactions and was highlighted by Aurora Cannabis Inc. (ACB.TO) (ACB) acquired two Licensed Producers for a combined price that was greater than $7 billion.

The second wave of acquisitions took place in 2018 and 2019 and was primarily related to US cannabis retailers. Since cannabis is illegal at the federal level in the US, these transactions took much long to complete (when compared to Canada) and many of the deals were scrapped due to plunging stock prices. The most significant failed acquisition in this vertical was MedMen Enterprises’ (MMEN.CN) (MMNNF) deal to purchase Pharmacann. After this transaction was called off, MedMen has come under considerable pressure and was assigned a $0 price target from Canaccord Genuity (CF.TO).

From an acquisition standpoint, 2020 has been a slower than normal year for the cannabis sector. Companies are being much more strategic when it comes to acquiring or investing in businesses that could be complementary or accretive in nature.

One of the more interested trends that we have identified with the cannabis M&A market is related to the types of businesses that are being purchased. Previously, cannabis companies were focused on acquiring assets that would increase production capacity, improve brand awareness, or expand into a different vertical.

In the current market environment, technology is playing a much larger role in M&A activity and we consider this to be the third wave of acquisitions. In this phase, we believe that companies are focused on purchasing businesses that can lead to margin expansion, positive cash flow generation, or improved profitability.

One of the best examples of this is the merger between Stem Holdings Inc. (STEM.CN) (STMH) and Driven Deliveries Inc. (DRVD). The companies operate completely different businesses and are levered to different parts of the cannabis value chain. We consider the merger to be strategic in nature and expect the combined company to record stronger revenue growth, margin expansion, and positive adjusted EBITDA.

Stem Holdings owns cannabis assets that are located in strategic US markets. Driven utilizes a state-of-the-art delivery platform to service the California cannabis market. The combined company can use Driven’s technology to capitalize on cannabis delivery opportunity in the markets that Stem is levered to and are bullish on the potential value that can be created through this strategy.

At current levels, the combined company is trading at a considerable discount to its peers and we believe that it has a compelling valuation. Due to the technology side of the business, the combined company should be valued at a higher multiple and we believe that the market is missing out on something significant with it.

If you look at the performance of other cannabis companies that have acquired tech assets, you will notice a positive trend after an initial period of weakness. We are not sure if this is the case with Stem Holdings and Driven but are bullish on the long-term opportunity that is associated with the combined company.

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Authored By

Michael Berger

Michael Berger is Managing Partner of StoneBridge Partners LLC. SBP continues to drive market awareness for leading firms in the cannabis industry throughout the U.S. and abroad.

Source: https://technical420.com/cannabis-article/is-ma-going-to-heat-up-in-the-cannabis-sector-with-u-s-federal-legalization-right-around-the-corner/

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