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Is cannabidiol the ideal drug to treat non-motor Parkinson’s disease symptoms?

Parkinson’s disease (PD) is a chronic neurodegenerative disorder characterized by motor symptoms such as bradykinesia, rest tremor, postural disturbances, and rigidity. PD is also characterized by non-motor symptoms such as sleep disturbances, cognitive deficits, and psychiatric disorders such as psychosis, depression, and anxiety. The pharmacological treatment for these symptoms is limited in efficacy and induce significant adverse reactions, highlighting the need for better treatment options….

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Parkinson’s disease (PD) is a chronic neurodegenerative disorder characterized by motor symptoms such as bradykinesia, rest tremor, postural disturbances, and rigidity. PD is also characterized by non-motor symptoms such as sleep disturbances, cognitive deficits, and psychiatric disorders such as psychosis, depression, and anxiety. The pharmacological treatment for these symptoms is limited in efficacy and induce significant adverse reactions, highlighting the need for better treatment options. Cannabidiol (CBD) is a phytocannabinoid devoid of the euphoriant and cognitive effects of tetrahydrocannabinol, and preclinical and preliminary clinical studies suggest that this compound has therapeutic effect in non-motor symptoms of PD. In the present text, we review the clinical studies of cannabinoids in PD and the preclinical and clinical studies specifically on CBD. We found four randomized controlled trials (RCTs) involving the administration of agonists/antagonists of the cannabinoid 1 receptor, showing that these compounds were well tolerated, but only one study found positive results (reductions on levodopa-induced dyskinesia). We found seven preclinical models of PD using CBD, with six studies showing a neuroprotective effect of CBD. We found three trials involving CBD and PD: an open-label study, a case series, and an RCT. CBD was well tolerated, and all three studies reported significant therapeutic effects in non-motor symptoms (psychosis, rapid eye movement sleep behaviour disorder, daily activities, and stigma). However, sample sizes were small and CBD treatment was short (up to 6 weeks). Large-scale RCTs are needed to try to replicate these results and to assess the long-term safety of CBD.

Keywords: Cannabidiol; Cannabinoids; Non-motor symptoms; Parkinson’s disease.

Source: https://pubmed.ncbi.nlm.nih.gov/30706171/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1LgINZmdEb7hTii13TOa5DGOR2cvkVQ2sw4N7-xSaEiod6ucE1&fc=20200804221722&ff=20200815003305&v=2.11.5

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Placed an order with Plain Jane, didn’t receive order confirmation email.

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Hey guys, just want to hear from some people who have ordered from them before and know if thats normal or not. This is my first time ordering from them, I took a screenshot when I checked out and it gave me my order number, I definitely put in the right email and stuff.

Usually most transactions online result in an instant email that notifies they got my order, I got nothing at all, just seems pretty weird and makes me a bit worried.

Is this normal?

Source: https://www.reddit.com/r/CBD/comments/ltugeb/placed_an_order_with_plain_jane_didnt_receive/

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I Tried Tommy Chong's Good Vibes Protocol CBD & It Changed Everything

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Oils, pills, even gummy bears — and it didn't do a thing for me. I wasn't the only one. I asked friends of mine, and most of us had tried CBD before and … Source:

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https://gayle-king-cbd-oil-review.medium.com/gayle-king-cbd-oil-real-reviews-and

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https://gayle-king-cbd-oil-review.medium.com/gayle-king-cbd-oil-real-reviews-and. Started by kaliertyiowe , Feb 27 2021 12:03 PM. Please log in to reply. Source:

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