Heartland

Is cannabidiol the ideal drug to treat non-motor Parkinson’s disease symptoms?

Published

2 years ago

February 2, 2019

Parkinson’s disease (PD) is a chronic neurodegenerative disorder characterized by motor symptoms such as bradykinesia, rest tremor, postural disturbances, and rigidity. PD is also characterized by non-motor symptoms such as sleep disturbances, cognitive deficits, and psychiatric disorders such as psychosis, depression, and anxiety. The pharmacological treatment for these symptoms is limited in efficacy and induce significant adverse reactions, highlighting the need for better treatment options. Cannabidiol (CBD) is a phytocannabinoid devoid of the euphoriant and cognitive effects of tetrahydrocannabinol, and preclinical and preliminary clinical studies suggest that this compound has therapeutic effect in non-motor symptoms of PD. In the present text, we review the clinical studies of cannabinoids in PD and the preclinical and clinical studies specifically on CBD. We found four randomized controlled trials (RCTs) involving the administration of agonists/antagonists of the cannabinoid 1 receptor, showing that these compounds were well tolerated, but only one study found positive results (reductions on levodopa-induced dyskinesia). We found seven preclinical models of PD using CBD, with six studies showing a neuroprotective effect of CBD. We found three trials involving CBD and PD: an open-label study, a case series, and an RCT. CBD was well tolerated, and all three studies reported significant therapeutic effects in non-motor symptoms (psychosis, rapid eye movement sleep behaviour disorder, daily activities, and stigma). However, sample sizes were small and CBD treatment was short (up to 6 weeks). Large-scale RCTs are needed to try to replicate these results and to assess the long-term safety of CBD.

Keywords: Cannabidiol; Cannabinoids; Non-motor symptoms; Parkinson’s disease.

Source: https://pubmed.ncbi.nlm.nih.gov/30706171/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1LgINZmdEb7hTii13TOa5DGOR2cvkVQ2sw4N7-xSaEiod6ucE1&fc=20200804221722&ff=20200815003305&v=2.11.5

Related Topics:cannabinoid cbd heartland safety

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Heartland

KIND Launches Mobile Payment App For The Cannabis Industry

The post KIND Launches Mobile Payment App For The Cannabis Industry appeared first on Green Market Report.

Published

5 hours ago

November 23, 2020

Republished by Plato

Paying for cannabis at a dispensary has always been challenging for both the customer and the dispensary owner. The refusal of major banks and credit cards to work with cannabis companies has resulted in a patchwork of increasingly creative ways to replicate the experience of using debit and credit cards. Many dispensaries often just install an ATM machine in the store for cash purchases, frequently hitting the consumer up for yet another expense to buy legal cannabis. Or the stores create some kind of electronic workaround that has been called into question by banking regulators. Now there is a new product that looks like it will have solved these problems but without the questionable financial gymnastics.

Tech company KindPay has created a closed-loop payment system, which means that it is able to be used only with specific merchants. Similar to other retail stores and industry mobile apps, users can credit their KindPay account with money from their debit and credit card. The mobile app will be able to be used by specific people in the cannabis industry, including dispensaries, growers, and consumers. KindPay is powered by Herring Bank, and according to the company, it is the cannabis industry’s first true closed-loop payment system. It is FDIC-insured and can be used with various debit and credit cards, including Visa, MasterCard, and Discover.

“The development and launch of KindPay has been long-awaited by the cannabis industry,” said KIND Financial founder David Dinenberg, “This new app will allow dispensaries, growers, and consumers alike, to transact transparently and safely. Also, due to the pandemic, contactless and cashless transactions have become safer ways to pay.”

KIND will support participating merchants by providing devices for merchants to process transactions with, as well as an Application Programming Interface (API) to allow virtually any point of sale system to integrate with KindPay.

KIND’s seed-to-sale software systems

Leading up to this groundbreaking mobile app launch, KIND provided software that allowed regulators, in real-time, to know where and how much cannabis and hemp is being grown, processed, or sold. They are a well-respected seed-to-sale tracking software, and now they are getting involved with the payment system side of things. With KindPay’s launch, cannabis merchants that have been traditionally declined will have a reliable and safe payment system to use. Traditional banks tend to decline cannabis businesses, even non-plant touching and ancillary businesses, because cannabis is seen as very high-risk. Due to cannabis’ Schedule I classification, it is federally illegal and therefore banks will more than likely not want to work with those in the industry – even those operating legally at the state level.

This cashless system also provides additional comfort for people worried about the coronavirus and physician transactions. The software will be available for legally operating cannabis business owners and operators.

The app will be free for consumers and available on the Apple App Store and Google Play Store.

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Source: https://www.greenmarketreport.com/kind-launches-mobile-payment-app-for-the-cannabis-industry/?utm_source=rss&utm_medium=rss&utm_campaign=kind-launches-mobile-payment-app-for-the-cannabis-industry

Heartland

CBD Full Spectrum Distillate

Published

5 hours ago

November 23, 2020

Republished by Plato

We don’t advertise it on our site but we would sell you some bulk full spectrum distillate.

Our hemp was organically grown in Minnesota and the distillate tests above 80%, I can get you the COA if you’re interested! We’re relatively new so we aren’t on the vendor list as of yet, but happy to provide whatever you need to feel confident in our products.

Our site is stillycbd.com, but we don’t advertise wholesale products there right now.

Source: https://www.reddit.com/r/CBD/comments/jzo725/cbd_full_spectrum_distillate/

Heartland

Martha Stewart™ CBD Wellness Gummies – 15 Flavor Sampler Coming Soon!

Published

7 hours ago

November 23, 2020

Republished by Plato

Martha Stewart™ CBD Wellness Gummies – 15 Flavor Gummy Sampler

Martha Stewart™ CBD Wellness Gummy Sampler Available For Pre Sale Wednesday November 18th

Find your inner Martha with the latest addition to the Martha Stewart™ CBD line of products. It’s no secret that the Martha Stewart™ CBD wellness gummies have been a big hit. This new 15 flavor gummy sampler includes a variety of flavors that Martha likes to bake with. Delicious gourmet gummy flavors developed by Martha Stewart herself. CBD wellness has never been this delicious or satisfying.

The Martha Stewart CBD Wellness Gummies include 10 mg of CBD isolate per gummy. Each 15 Flavor Sampler contains 60 total gummies and a total of 600mg CBD per container. Explore a variety of flavors as you incorporate these gummies into your wellness routine.

Martha Stewart™ CBD Wellness Gummies 15 Flavor Sampler (60ct) $64.99

Martha Stewart™ CBD Wellness 15 Flavor Gummy Sampler includes the following flavors:

red raspberry
huckleberry
rhubarb
passion fruit
persian lime
strawberry
pink grapefruit
calamondin
green apple
black currant
blood orange
kumquat
quince
meyer lemon
black raspberry

Martha Stewart™ CBD Wellness Gummies – 15 Flavor Gummy Sampler Coming Soon to Anavii Market

Anavii Market is one of the few exclusive third party retailers to carry Martha Stewart CBD Products. We are proud to offer this line of products carefully crafted in collaboration with Canopy Growth Corporation. Canopy is a leader in the CBD and Cannabis space, and Martha has a long history of helping people achieve Better Living. Canopy and Martha have collaborated to make CBD available to everyone in a simple and delicious way.

Martha Stewart™ CBD Wellness Gummies – 15 Flavor Gummy Sampler Available Wednesday November 18th 20% off for a Limited Time!

Martha Stewart CBD Wellness 15-Flavor Sampler will be available for order on Wednesday November 18th. Available just in time for the holidays. Show that special someone you care by buying them a Martha Stewart CBD 15-Flavor Gummy Sampler. This makes a perfect gift for your significant other, yourself, your friend, a family member, or someone you care about!

Source: https://www.anaviimarket.com/blogs/news/martha-stewart-cbd-wellness-gummies-15-flavor-sampler-now-available