Heartland
Impact of cannabidiol treatment on regulatory T-17 cells and neutrophil polarization in acute kidney injury
Hallmark features of acute kidney injury (AKI) include mobilization of immune and inflammatory mechanisms culminating in tissue injury. Emerging information indicates heterogeneity of neutrophils with pro- and anti-inflammatory functions (N1 and N2, respectively). Also, regulatory T-17 (Treg17) cells curtail T helper 17 (Th-17)-mediated proinflammatory responses. However, the status of Treg17 cells and neutrophil phenotypes in AKI are not established. Furthermore, cannabidiol exerts…
Hallmark features of acute kidney injury (AKI) include mobilization of immune and inflammatory mechanisms culminating in tissue injury. Emerging information indicates heterogeneity of neutrophils with pro- and anti-inflammatory functions (N1 and N2, respectively). Also, regulatory T-17 (Treg17) cells curtail T helper 17 (Th-17)-mediated proinflammatory responses. However, the status of Treg17 cells and neutrophil phenotypes in AKI are not established. Furthermore, cannabidiol exerts immunoregulatory effects, but its impact on Treg17 cells and neutrophil subtypes is not established. Thus, we examined the status of Treg17 cells and neutrophil subtypes in AKI and determined whether cannabidiol favors regulatory neutrophils and T cells accompanied with renoprotection. Accordingly, mice were subjected to bilateral renal ischemia-reperfusion injury (IRI), without or with cannabidiol treatment; thereafter, kidneys were processed for flow cytometry analyses. Renal IRI increased N1 and Th-17 but reduced N2 and Treg17 cells accompanied with disruption of mitochondrial membrane potential (ψm) and increased apoptosis/necrosis and kidney injury molecule-1 (KIM-1) immunostaining compared with their sham controls. Importantly, cannabidiol treatment preserved ψm and reduced cell death and KIM-1 accompanied by restoration of N1 and N2 imbalance and preservation of Treg17 cells while decreasing Th-17 cells. The ability of cannabidiol to favor development of Treg17 cells was further established using functional mixed lymphocytic reaction. Subsequent studies showed higher renal blood flow and reduced serum creatinine in cannabidiol-treated IRI animals. Collectively, our novel observations establish that renal IRI causes neutrophil polarization in favor of N1 and also reduces Treg17 cells in favor of Th-17, effects that are reversed by cannabidiol treatment accompanied with significant renoprotection.
Keywords: CBD; acute kidney injury; cannabidiol; neutrophil polarization; regulatory T-17 cells.
Heartland
Global Hemp-Based Food Market 2020 – Sales, Price, Revenue, Gross Margin And Forecast By …
“Hemp-Based Food Market 2020”
New Study Reports “Hemp-Based Food Market 2020 Global Market Opportunities, Challenges, Strategies and Forecasts 2026” has been Added on WiseGuyReports.
Hemp-Based Food Market 2020-2026
New Study Reports “Hemp-Based Food Market 2020 Global Market Opportunities, Challenges, Strategies and Forecasts 2026” has been Added on WiseGuyReports.
Report Summary:-
The Global Hemp-Based Food Market Report 2020-2026 (Forecast Period) Offers An In-Depth Study Of Market Growth Factors, Future Evaluation, Country-Level Analysis, Hemp-Based Food Market Distribution, And Competitive Landscape Study Of Significant Industry Players. Every Segment Of The Global Hemp-Based Food Market Is Extensively Assessed In The Research Report. The Segment Analysis Offers Critical Opportunities Available In The Global Hemp-Based Food Market Through Leading Segments. The Regional Study Of The Global Hemp-Based Food Market Helps Readers To Attain A Thorough Understanding Of The Developments Of The Different Geographic Markets In Recent Years And Also Going Forth. In Addition, The Report Provides A Comprehensive Overview Of The Vital Dynamics Of The Global Hemp-Based Food Market, Including Market Influence And Market Effect Factors, Drivers, Threats, Constraints, Trends, And Prospects. The Research Study Also Contains Other Forms Of Analysis, Such As Qualitative And Quantitative.
The report includes country-wise and region-wise market size for the period 2015-2026. It also includes market size and forecast by Type, and by Application segment in terms of sales and revenue for the period 2015-2026.
Competitive Landscape and Hemp-Based Food Market Share Analysis:-
Hemp-Based Food market competitive landscape provides details and data information by players. The report offers comprehensive analysis and accurate statistics on revenue by the player for the period 2015-2020. It also offers detailed analysis supported by reliable statistics on revenue (global and regional level) by players for the period 2015-2020. Details included are company description, major business, company total revenue and the sales, revenue generated in Hemp-Based Food business, the date to enter into the Hemp-Based Food market, Hemp-Based Food product introduction, recent developments, etc.
The major vendors covered:
CompassDiversifiedHoldings
Hempco
Hemp Foods Australia
Canopy Growth
NaturallySplendidEnterprises
Nutiva
Agropro
Nutiva
Manitoba Harvest
Braham & Murray
GIGO Food
Elixinol
Mettrum Originals
Jinzhou Qiaopai Biotech
Request Free Sample Report @ https://www.wiseguyreports.com/sample-request/6089806-global-and-japan-hemp-based-food-market-insights-forecast-to-2026
Market Dynamics:-
The report also examines the several volume trends, the pricing history, and the market value in addition to understanding the key dynamics of the Hemp-Based Food market. Several future growth drivers, challenges, and opportunities are also analyzed to obtain a better view of the industry.
Hemp-Based Food market is segmented by region (country), players, by Type, and by Application. Players, stakeholders, and other participants in the global Hemp-Based Food market will be able to gain the upper hand as they use the report as a powerful resource. The segmental analysis focuses on revenue and forecast by region (country), by Type and by Application in terms of revenue and forecast for the period 2015-2026.
Segment by Type, the Hemp-Based Food market is segmented into
Hemp seed-based foods
Hemp protein-based foods
Hemp oil-based foods
Segment by Application, the Hemp-Based Food market is segmented into
Supermarkets
Convenience Stores
Others
Regional and Country-level Analysis
The Hemp-Based Food market is analysed and market size information is provided by regions (countries).
The key regions covered in the Hemp-Based Food market report are North America, Europe, Asia Pacific, Latin America, Middle East and Africa. It also covers key regions (countries), viz, U.S., Canada, Germany, France, U.K., Italy, Russia, China, Japan, South Korea, India, Australia, Taiwan, Indonesia, Thailand, Malaysia, Philippines, Vietnam, Mexico, Brazil, Turkey, Saudi Arabia, U.A.E, etc.
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If you have any special requirements, please let us know and we will offer you the report as you want.
Major Key Points from Table of Content:
1 Study Coverage
1.1 Hemp-Based Food Product Introduction
1.2 Market Segments
1.3 Key Hemp-Based Food Manufacturers Covered: Ranking by Revenue
1.4 Market by Type
1.4.1 Global Hemp-Based Food Market Size Growth Rate by Type
1.4.2 Hemp seed-based foods
1.4.3 Hemp protein-based foods
1.4.4 Hemp oil-based foods
1.5 Market by Application
1.5.1 Global Hemp-Based Food Market Size Growth Rate by Application
1.5.2 Supermarkets
1.5.3 Convenience Stores
1.5.4 Others
1.6 Study Objectives
1.7 Years Considered
……
12 Company Profiles
12.1 CompassDiversifiedHoldings
12.1.1 CompassDiversifiedHoldings Corporation Information
12.1.2 CompassDiversifiedHoldings Description and Business Overview
12.1.3 CompassDiversifiedHoldings Sales, Revenue and Gross Margin (2015-2020)
12.1.4 CompassDiversifiedHoldings Hemp-Based Food Products Offered
12.1.5 CompassDiversifiedHoldings Recent Development
12.2 Hempco
12.2.1 Hempco Corporation Information
12.2.2 Hempco Description and Business Overview
12.2.3 Hempco Sales, Revenue and Gross Margin (2015-2020)
12.2.4 Hempco Hemp-Based Food Products Offered
12.2.5 Hempco Recent Development
12.3 Hemp Foods Australia
12.3.1 Hemp Foods Australia Corporation Information
12.3.2 Hemp Foods Australia Description and Business Overview
12.3.3 Hemp Foods Australia Sales, Revenue and Gross Margin (2015-2020)
12.3.4 Hemp Foods Australia Hemp-Based Food Products Offered
12.3.5 Hemp Foods Australia Recent Development
12.4 Canopy Growth
12.4.1 Canopy Growth Corporation Information
12.4.2 Canopy Growth Description and Business Overview
12.4.3 Canopy Growth Sales, Revenue and Gross Margin (2015-2020)
12.4.4 Canopy Growth Hemp-Based Food Products Offered
12.4.5 Canopy Growth Recent Development
12.5 NaturallySplendidEnterprises
12.5.1 NaturallySplendidEnterprises Corporation Information
12.5.2 NaturallySplendidEnterprises Description and Business Overview
12.5.3 NaturallySplendidEnterprises Sales, Revenue and Gross Margin (2015-2020)
12.5.4 NaturallySplendidEnterprises Hemp-Based Food Products Offered
12.5.5 NaturallySplendidEnterprises Recent Development
12.6 Nutiva
12.6.1 Nutiva Corporation Information
12.6.2 Nutiva Description and Business Overview
12.6.3 Nutiva Sales, Revenue and Gross Margin (2015-2020)
12.6.4 Nutiva Hemp-Based Food Products Offered
12.6.5 Nutiva Recent Development
12.7 Agropro
12.7.1 Agropro Corporation Information
12.7.2 Agropro Description and Business Overview
12.7.3 Agropro Sales, Revenue and Gross Margin (2015-2020)
12.7.4 Agropro Hemp-Based Food Products Offered
12.7.5 Agropro Recent Development
12.8 Nutiva
12.8.1 Nutiva Corporation Information
12.8.2 Nutiva Description and Business Overview
12.8.3 Nutiva Sales, Revenue and Gross Margin (2015-2020)
12.8.4 Nutiva Hemp-Based Food Products Offered
12.8.5 Nutiva Recent Development
12.9 Manitoba Harvest
12.9.1 Manitoba Harvest Corporation Information
12.9.2 Manitoba Harvest Description and Business Overview
12.9.3 Manitoba Harvest Sales, Revenue and Gross Margin (2015-2020)
12.9.4 Manitoba Harvest Hemp-Based Food Products Offered
12.9.5 Manitoba Harvest Recent Development
12.10 Braham & Murray
Continued…..
NOTE : Our team is studying Covid-19 and its impact on various industry verticals and wherever required we will be considering Covid-19 footprints for a better analysis of markets and industries. Cordially get in touch for more details.
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The Narcotics Control Board decided to remove cannabis from the list of narcotics, category 5 to allow wider use for medicinal purposes.
Permanent Secretary for Public Health, Kiarttiphum Wongjit and Secretary-General of the Food and Drug Administration, Paisan Dankhum told a press briefing that the Narcotics Control Board resolved to remove leaves, stems, stalks and roots of cannabis plants including both Kancha and Kanchong from the narcotics list.
The removal is to pave the way for more access to use cannabis for medical purposes as well as in textile, cosmetic and pharmaceutical industries.
Hemp plants will be promoted as the new cash crops.
After the board’s decision, the Food and Drug Administration (FDA) will propose the draft ministerial regulation to the Public Health Minister to sign and it will be published in the Royal Gazette and put into effect.
The draft ministerial regulation stipulates that cannabis plants, officially allowed to grow or be extracted in Thailand will no longer be considered as the narcotics, category 5.
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However, permanent secretary for public health said despite the delisting of cannabis, initially, only government agencies and community enterprises who work with the government agencies can grow cannabis and must seek permission from the FDA.
Recreational use of cannabis is still illegal. (TNA)
Heartland
The Roll-up #173: Why we’re thankful for the garbage year of 2020. Yes, 2020.
This week Bruce, Alyssa, and Hannah chew through 2020 and all its robust, savory goodness.
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Source: https://www.leafly.com/news/podcasts/thankful-for-garbage-year-2020
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