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How does cannabidiol (CBD) influence the acute effects of delta-9-tetrahydrocannabinol (THC) in humans? A systematic review

Published

1 year ago

October 4, 2019

Republished by Plato

. 2019 Dec;107:696-712.

doi: 10.1016/j.neubiorev.2019.09.036. Epub 2019 Sep 30.

Affiliations

¹ Clinical Psychopharmacology Unit, University College London, Gower Street, London, WC1E 6BT, UK. Electronic address: abigail.freeman@ucl.ac.uk.
² Clinical Psychopharmacology Unit, University College London, Gower Street, London, WC1E 6BT, UK.
³ Clinical Psychopharmacology Unit, University College London, Gower Street, London, WC1E 6BT, UK; Addiction and Mental Health Group (AIM), University of Bath, Bath, BA2 7AY, UK.
⁴ Clinical Psychopharmacology Unit, University College London, Gower Street, London, WC1E 6BT, UK; Translational Psychiatry Research Group, Research Department of Mental Health Neuroscience, Division of Psychiatry, University College London, Gower Street, London, WC1E 6BT, UK.
⁵ Clinical Psychopharmacology Unit, University College London, Gower Street, London, WC1E 6BT, UK; Addiction and Mental Health Group (AIM), University of Bath, Bath, BA2 7AY, UK; National Addiction Centre, King’s College London, London, SE5 8BB, UK.

Item in Clipboard

Abigail M Freeman et al. Neurosci Biobehav Rev. 2019 Dec.

. 2019 Dec;107:696-712.

doi: 10.1016/j.neubiorev.2019.09.036. Epub 2019 Sep 30.

Affiliations

¹ Clinical Psychopharmacology Unit, University College London, Gower Street, London, WC1E 6BT, UK. Electronic address: abigail.freeman@ucl.ac.uk.
² Clinical Psychopharmacology Unit, University College London, Gower Street, London, WC1E 6BT, UK.
³ Clinical Psychopharmacology Unit, University College London, Gower Street, London, WC1E 6BT, UK; Addiction and Mental Health Group (AIM), University of Bath, Bath, BA2 7AY, UK.
⁴ Clinical Psychopharmacology Unit, University College London, Gower Street, London, WC1E 6BT, UK; Translational Psychiatry Research Group, Research Department of Mental Health Neuroscience, Division of Psychiatry, University College London, Gower Street, London, WC1E 6BT, UK.
⁵ Clinical Psychopharmacology Unit, University College London, Gower Street, London, WC1E 6BT, UK; Addiction and Mental Health Group (AIM), University of Bath, Bath, BA2 7AY, UK; National Addiction Centre, King’s College London, London, SE5 8BB, UK.

Item in Clipboard

Abstract

The recent liberalisation of cannabis regulation has increased public and scientific debate about its potential benefits and risks. A key focus has been the extent to which cannabidiol (CBD) might influence the acute effects of delta-9-tetrahydrocannabinol (THC), but this has never been reviewed systematically. In this systematic review of how CBD influences the acute effects of THC we identified 16 studies involving 466 participants. Ten studies were judged at low risk of bias. The findings were mixed, although CBD was found to reduce the effects of THC in several studies. Some studies found that CBD reduced intense experiences of anxiety or psychosis-like effects of THC and blunted some of the impairments on emotion and reward processing. However, CBD did not consistently influence the effects of THC across all studies and outcomes. There was considerable heterogeneity in dose, route of administration and THC:CBD ratio across studies and no clear dose-response profile emerged. Although findings were mixed, this review suggests that CBD may interact with some acute effects of THC.

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THC and CBD blood and brain concentrations following daily administration to adolescent primates.

Withey SL, Bergman J, Huestis MA, George SR, Madras BK. Withey SL, et al. Drug Alcohol Depend. 2020 Jun 18;213:108129. doi: 10.1016/j.drugalcdep.2020.108129. Online ahead of print. Drug Alcohol Depend. 2020. PMID: 32593153
[Neurodevelopment and Cannabis].

Krebs MO, Demars F, Frajerman A, Kebir O, Jay T. Krebs MO, et al. Bull Acad Natl Med. 2020 Apr 17;204(6):561-9. doi: 10.1016/j.banm.2020.04.002. Online ahead of print. Bull Acad Natl Med. 2020. PMID: 32308209 Free PMC article. Review. French.
Cannabinoids, Blood-Brain Barrier, and Brain Disposition.

Calapai F, Cardia L, Sorbara EE, Navarra M, Gangemi S, Calapai G, Mannucci C. Calapai F, et al. Pharmaceutics. 2020 Mar 15;12(3):265. doi: 10.3390/pharmaceutics12030265. Pharmaceutics. 2020. PMID: 32183416 Free PMC article. Review.
Factors Moderating the Association Between Cannabis Use and Psychosis Risk: A Systematic Review.

van der Steur SJ, Batalla A, Bossong MG. van der Steur SJ, et al. Brain Sci. 2020 Feb 12;10(2):97. doi: 10.3390/brainsci10020097. Brain Sci. 2020. PMID: 32059350 Free PMC article. Review.
Bridging the Accessibility Gap of Cannabinoid Medicine and Arabic Culture.

Robinson D, Ritter S, Zadik-Weiss L, Ounallah-Saad H, Abu-Ahmad N, Kashkoosh R, Yassin M, Or R. Robinson D, et al. Rambam Maimonides Med J. 2020 Jan 30;11(1):e0010. doi: 10.5041/RMMJ.10392. Rambam Maimonides Med J. 2020. PMID: 32017683 Free PMC article. Review.

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Source: https://pubmed.ncbi.nlm.nih.gov/31580839/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1LgINZmdEb7hTii13TOa5DGOR2cvkVQ2sw4N7-xSaEiod6ucE1&fc=20200804221722&ff=20200812155154&v=2.11.5

Related Topics:cannabinoid cannabis cbd heartland medicine regulation research risk search thc

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3 Global Pet CBD(cannabidiol) Sales, Revenue, Market Share and Competition by Manufacturer
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5 North America Pet CBD(cannabidiol) by Countries
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7 Asia-Pacific Pet CBD(cannabidiol) by Countries
8 South America Pet CBD(cannabidiol) by Countries
9 Middle East and Africa Pet CBD(cannabidiol) by Countries
10 Global Pet CBD(cannabidiol) Market Segment by Type
11 Global Pet CBD(cannabidiol) Market Segment by Application
12 Pet CBD(cannabidiol) Market Forecast
13 Sales Channel, Distributors, Traders and Dealers
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How does cannabidiol (CBD) influence the acute effects of delta-9-tetrahydrocannabinol (THC) in humans? A systematic review

Abstract

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