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High times for cannabis: Epigenetic imprint and its legacy on brain and behavior
Extensive debates continue regarding marijuana (Cannabis spp), the most commonly used illicit substance in many countries worldwide. There has been an exponential increase of cannabis studies over the past two decades but the drug’s long-term effects still lack in-depth scientific data. The epigenome is a critical molecular machinery with the capacity to maintain persistent alterations of gene expression and behaviors induced by cannabinoids that have been observed across the individual’s…
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. 2018 Feb;85:93-101.
doi: 10.1016/j.neubiorev.2017.05.011. Epub 2017 May 12.
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Abstract
Extensive debates continue regarding marijuana (Cannabis spp), the most commonly used illicit substance in many countries worldwide. There has been an exponential increase of cannabis studies over the past two decades but the drug’s long-term effects still lack in-depth scientific data. The epigenome is a critical molecular machinery with the capacity to maintain persistent alterations of gene expression and behaviors induced by cannabinoids that have been observed across the individual’s lifespan and even into the subsequent generation. Though mechanistic investigations regarding the consequences of developmental cannabis exposure remain sparse, human and animal studies have begun to reveal specific epigenetic disruptions in the brain and the periphery. In this article, we focus attention on long-term disturbances in epigenetic regulation in relation to prenatal, adolescent and parental germline cannabinoid exposure. Expanding knowledge about the protracted molecular memory could help to identify novel targets to develop preventive strategies and treatments for behaviors relevant to neuropsychiatric risks associated with developmental cannabis exposure.
Keywords: Adolescence; Cannabinoid; Chromatin; DNA methylation; Epigenetics; Multigenerational inheritance; Prenatal development; Synaptic plasticity; Transcription.
Copyright © 2017 Elsevier Ltd. All rights reserved.
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The two most likely populations to use cannabis are pregnant women and adolescents (indicated by green arrow on top). These developmental phases also correspond to periods when the brain is most vulnerable to the influence of external cannabinoids via interfering with epigenetic mechanisms (shown below the schematic of the developmental cycle). Several epigenetic mechanisms that are relevant to the effects of cannabinoids can interfere with normal gene expression via interacting with DNA elements (e.g. promoters) and transcription factors (proteins that bind to the DNA) to regulate mRNA transcript levels from a gene. Specific regulatory mechanisms include DNA methylation (Me), positioning and post-translational modifications of nucleosomes (small blue balls), recruitment of the transcription complex (sequence-specific and basal transcription factors, RNA polymerase II), and non-coding RNAs. DNA methyltranserases (DNMT) generate 5-methylcytosine (pink stars) at CpG sites. Ten-eleven translocation (TET) proteins mediate the oxidation of 5-methylcytosine to 5-hydroxymethylcytosine (green stars), leading to demethylation of the DNA. Modifications of nucleosomal histone tails such as methylation (Me) and acetylation (Ac) are mediated by histone methyltransferases (HMT) and histone acetyltransferases (HAT), respectively. Small RNAs are produced from specific genes and either influence the transcription process or target protein-coding messenger RNAs for degradation. Germ cells (sperm, oocyte) are also sensitive to cannabinoids but the exact underlying epigenetic mechanisms remain to be determined.
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30 Best Stoner Coloring Books on Amazon
We’ve put together a comprehensive list of the 30 best stoner coloring books on Amazon! These weed-themed coloring books make …
Read more30 Best Stoner Coloring Books on Amazon
The post 30 Best Stoner Coloring Books on Amazon appeared first on The Cannabis School.
We’ve put together a comprehensive list of the 30 best stoner coloring books on Amazon! These weed-themed coloring books make for a fun activity that helps spark your creativity and imagination. Each coloring book found below will have a direct link to it’s listing on Amazon, this will help you easily view or purchase it. Activities like this help enhance the cannabis experience by allowing the user to concentrate on a fun task. The level of your visual indulgence during your “high” is important in determining how much you’ll enjoy it. In other words, what better tools for meditation and recreation than cannabis and coloring?
The condensed list below contains the links to all the best stoner coloring books found in this article:
Condensed List:
- The Stoner’s Psychedelic Coloring Book
- A Coloring Book For Stoners: Stress Relieving Psychedelic Art For Adults
- Let’s Get High And Color: An Adult Coloring Book
- Stoner Things: Stoner Coloring Book
- Stoner Things Volume 2: Colouring Book for Adults
- Princess Stoner Coloring Book
- Disney Princess Stoner Coloring Book:
- Princess Stoner Coloring Book: Great Coloring Book For Adults Stress Relief & Relaxation
- Princess Coloring Book: Cool and Relaxing Design – Great Coloring Book for Adults Relaxation and Stress Relief
- Disney Stoner Colouring Book:
- The Stoner Babes Coloring Book By Katie Guinn
- Trippy Chicks Adult Coloring Book
- Stoner Coloring Book: The Psychedelic Coloring Book for Relaxation and Stress Relief, Stoner Coloring
- Animals Smoking Weed: Colouring Book By Kristin Harris
- Wiz Khalifa’s Weed Farm Coloring Book
- Fresh Baked Cannabis Coloring Book for Weed Lovers: Volume 3
- Fresh Baked Cannabis Coloring Book for Weed Lovers: Fun Marijuana and Pot Themed Images to Color – Volume 1
- Fresh Baked Cannabis Coloring Book
- Marijuana Strains: Adult Coloring Book
- Stoner Coloring Book: The Stoner’s Psychedelic Coloring Book
- Trippy Advisor- An Irreverent Coloring Book For Adults:
- Day Trip: The Stoner’s Psychedelic Coloring Book
- Stoner Coloring Book: A Psychedelic Coloring Book for Adults
- Not Your Kids Stoner Coloring Book:
- A Psychedelic Coloring Book For Adults:
- Psychedelic Coloring Book
- The Trippy Hippie Coloring Book
- Reefer Madness Mandala and Quote Coloring Book For Adults:
- Stoner Activity Book
- High Life Coloring & Activity Book (Volume 1)

Red, glossy eyes are the trademark of a good high. This stoner coloring book features 25 hand-drawn stoner designs for you to color. With 50 pages in total, you don’t even have to worry about ruining the next page’s design with your color’s tint.
It comes in two price variants, $7.99 for paperback and $20.49 for a spiral bound book, perfect for gifts! Oh and it has a free PDF inside too!
Product Features:
- 25 unique designs
- 50 single side printing on both white and black papers
- Available in paperback and spiral bound variants
- Free PDF!
If you liked this, check out a similar one below:

Price: $4.99

Get your hands on this humorous coloring book which includes 17 unique designs and “black light” versions of 15 of them, making a total of 33 pages to color!
Product Features:
- 66 total pages with 33 single-side printed pages to color
- 17 unique designs
- Glossy paper
- Suitable for pencil colours, markers, pens and crayons

With the title inspired by the Netflix hit show “Stranger Things”, this is a perfect gift for fans of the show! The book includes 16 unique designs and also includes inverted background versions for many of them. One of the best stoner coloring books.
Product Features:
- 31 pages to colour
- 16 unique designs
- Glossy paper
- Suitable for color pencils, pens, markers and crayons.
Not quite satisfied? Check out another “Stranger Things” inspired option below!


Calling all our stoner girls! This Disney princess inspired stoner coloring book has all your favourite Disney princess stories with a 420 twist. Now you get to reimagine all the fairytales while in your most creative state.
Product Features:
- 27 unique designs 54 pages in total
- Single side high quality printed pages
- Suitable for colouring pencils, markers, crayons etc
If you liked this theme, check out similar princess stoner colouring books below!




Another one for our Disney lovers, because who doesn’t love this dynamic six! We can already hear Donald Duck’s high quacks!
Product Features:
- 25 unique illustrations
- High quality paper
- Single side printing
- 8.5*11 inches size

This artistic representation of empowered women and gender fluid people who relish the herb is a wonderful gift for all the intellectual and mindful people in your friend circle. With over 60 intricate images of tattoos, marijuana bouquets, patterned garb, shape-filled backgrounds and gorgeous faces, you’ll find new meanings to life inspired by the art in this colouring book!
Product Features:
- 60 single-sided printed pages
- High-quality paper
- 8.5*11 inches size
- Suitable for pencil colours, crayons, markers etc.
If you liked this artistry, then check out the next similar one below!

The Trippy Chicks Coloring book features mystical women channelling their inner goddesses. Expect to find religious symbols, long locks, reptiles and mandalas.

Presenting another gift option for our stoner guys, although with designs so intricate and detailed, even the girls won’t be able to resist it. You can draw for days on end with this book, filling it with colours and creating your own psychedelic paradise.
Product Features:
- Premium glossy cover
- Single sided pages to avoid bleed through
- 8.5*11 inches size
- High quality white paper

From the Dinosaurs of Jurassic Park to reefer madness and game of stoned, this book is guaranteed to leave you in fits of laughter. Kristin Harris really amped up his game with this one!
Product Features:
- 26 unique images
- Test image to try out your colors
- High-quality paper
- 8.5*11 inches size

Wiz Khalifa is back yet again with a pro-cannabis statement in the form of his new product “The Wiz Khalifa Weed Farm Coloring Book”.
This stress-relieving coloring book is slightly on the pricier edge, going at $14.95, but is rightly so, because with featured iconic images from LA to Amsterdam and events like Danksgiving and Wiz’s Birthday, it’s a direct sneak peek into Khalifa’s weed empire!

The Fresh Baked series is a designer brainchild of independent artists who came together to design fun pot-themed images and humourous marijuana designs for people who like to relieve stress through coloring while high.
Product Features:
- Fun cannabis inspired designs
- Original images
- High-quality paper
- 8.5*11 inches size
- Part of a series of three
If you liked this, be sure to check out Fresh Baked Volume 1 and 2! A perfect gift bundle for Birthdays or Christmas!


Not all Cannabis is the same. There are a ton of varieties and so many different strains to choose from. Check out this colouring book that not only lets you have a fun time with Cannabis, but also educates you on the different varieties out there. The book has illustrations of popular strains like the Harlequin, Grape Ape, Dance World, Cherry Pie, Frankenstein, and Laughing Buddha. One of the best stoner coloring books.
So gather your friends and take turns to color and try the Cannabis varieties drawn in the book, who knows, you may find your next favourite party strain here!
Product Features:
- Paperback
- Unique Illustrations
- Cannabis strain designs
- 8.5*11 inches size

Does your trip make you feel like a part of an alternate universe too? If so, you will love this coloring book that transports you directly into a psychedelic world.
Product Features:
- 30 high quality illustrations
- Single side printing to avoid bleed through
- 8.5 x 11’’ size
If you liked this, check out similar books that also promise a great trip!






Marijuana, meditate and contemplate: that’s our mantra. With 35 unique and beautiful kaleidoscopic designs, color in magical mushrooms and mandalas and make your trip a memorable one.
Product Features:
- 8.5*11 sized pages
- Single-sided printing on white paper
- 35 unique illustrations
- High quality 60lb paper
If you like coloring in Mandalas, check out these two as well:



We saved the absolute best for the last. Get your hands on the Stoner Activity Book that not only has coloring pages, but also crosswords, puzzles, trippy mazes and more for a variety of activities to do while high!
If you like this type of product, also check out this stoner coloring and activity book:

So there you have it! The 30 best stoner coloring books on Amazon! If you enjoyed this list, check out our article on the 30 Best Stoner Gifts on Amazon! Leave a comment with what you would like to see next!
Source: https://www.thecannaschool.ca/best-stoner-coloring-books/
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