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High times for cannabis: Epigenetic imprint and its legacy on brain and behavior

Published

4 years ago

May 17, 2017

Republished by Plato

Review

. 2018 Feb;85:93-101.

doi: 10.1016/j.neubiorev.2017.05.011. Epub 2017 May 12.

Affiliations

Free PMC article

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Review

Henrietta Szutorisz et al. Neurosci Biobehav Rev. 2018 Feb.

Free PMC article

. 2018 Feb;85:93-101.

doi: 10.1016/j.neubiorev.2017.05.011. Epub 2017 May 12.

Affiliations

¹ Friedman Brain Institute, Departments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
² Friedman Brain Institute, Departments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Addiction Institute at Mount Sinai, New York, NY, USA. Electronic address: yasmin.hurd@mssm.edu.

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Abstract

Extensive debates continue regarding marijuana (Cannabis spp), the most commonly used illicit substance in many countries worldwide. There has been an exponential increase of cannabis studies over the past two decades but the drug’s long-term effects still lack in-depth scientific data. The epigenome is a critical molecular machinery with the capacity to maintain persistent alterations of gene expression and behaviors induced by cannabinoids that have been observed across the individual’s lifespan and even into the subsequent generation. Though mechanistic investigations regarding the consequences of developmental cannabis exposure remain sparse, human and animal studies have begun to reveal specific epigenetic disruptions in the brain and the periphery. In this article, we focus attention on long-term disturbances in epigenetic regulation in relation to prenatal, adolescent and parental germline cannabinoid exposure. Expanding knowledge about the protracted molecular memory could help to identify novel targets to develop preventive strategies and treatments for behaviors relevant to neuropsychiatric risks associated with developmental cannabis exposure.

Keywords: Adolescence; Cannabinoid; Chromatin; DNA methylation; Epigenetics; Multigenerational inheritance; Prenatal development; Synaptic plasticity; Transcription.

Figures

**Figure 1. Cannabis exposure during sensitive periods of development can impact epigenetic mechanisms, leading to persistent gene regulation and behavioral alterations**

The two most likely populations to use cannabis are pregnant women and adolescents (indicated by green arrow on top). These developmental phases also correspond to periods when the brain is most vulnerable to the influence of external cannabinoids via interfering with epigenetic mechanisms (shown below the schematic of the developmental cycle). Several epigenetic mechanisms that are relevant to the effects of cannabinoids can interfere with normal gene expression via interacting with *DNA* elements (e.g. promoters) and transcription factors (proteins that bind to the DNA) to regulate mRNA transcript levels from a gene. Specific regulatory mechanisms include DNA methylation (Me), positioning and post-translational modifications of nucleosomes (small blue balls), recruitment of the transcription complex (sequence-specific and basal transcription factors, RNA polymerase II), and non-coding RNAs. DNA methyltranserases (DNMT) generate 5-methylcytosine (pink stars) at CpG sites. Ten-eleven translocation (TET) proteins mediate the oxidation of 5-methylcytosine to 5-hydroxymethylcytosine (green stars), leading to demethylation of the DNA. Modifications of nucleosomal histone tails such as methylation (Me) and acetylation (Ac) are mediated by histone methyltransferases (HMT) and histone acetyltransferases (HAT), respectively. Small RNAs are produced from specific genes and either influence the transcription process or target protein-coding messenger RNAs for degradation. Germ cells (sperm, oocyte) are also sensitive to cannabinoids but the exact underlying epigenetic mechanisms remain to be determined.

Cited by 21 articles

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Archie SR, Cucullo L. Archie SR, et al. Int J Mol Sci. 2020 May 30;21(11):3916. doi: 10.3390/ijms21113916. Int J Mol Sci. 2020. PMID: 32486196 Free PMC article. Review.
[Neurodevelopment and Cannabis].

Krebs MO, Demars F, Frajerman A, Kebir O, Jay T. Krebs MO, et al. Bull Acad Natl Med. 2020 Apr 17;204(6):561-9. doi: 10.1016/j.banm.2020.04.002. Online ahead of print. Bull Acad Natl Med. 2020. PMID: 32308209 Free PMC article. Review. French.
Cannabis use and the sperm epigenome: a budding concern?

Schrott R, Murphy SK. Schrott R, et al. Environ Epigenet. 2020 Mar 19;6(1):dvaa002. doi: 10.1093/eep/dvaa002. eCollection 2020 Jan. Environ Epigenet. 2020. PMID: 32211199 Free PMC article. Review.
Harmful Effects of Smoking Cannabis: A Cerebrovascular and Neurological Perspective.

Archie SR, Cucullo L. Archie SR, et al. Front Pharmacol. 2019 Dec 6;10:1481. doi: 10.3389/fphar.2019.01481. eCollection 2019. Front Pharmacol. 2019. PMID: 31920665 Free PMC article. Review.
Gestational exposure to the cannabinoid WIN 55,212-2 and its effect on the innate intestinal immune response.

Hernández-Cervantes R, Pérez-Torres A, Prospéro-García Ó, Morales Montor J. Hernández-Cervantes R, et al. Sci Rep. 2019 Dec 30;9(1):20340. doi: 10.1038/s41598-019-56653-y. Sci Rep. 2019. PMID: 31889093 Free PMC article.

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Source: https://pubmed.ncbi.nlm.nih.gov/28506926/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1z7zlNEMzQex5jriqkhCblNtckSEpT9xYlxxeymU_73UTETESY&fc=20200804213258&ff=20200810171721&v=2.11.5

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30 Best Stoner Coloring Books on Amazon

We’ve put together a comprehensive list of the 30 best stoner coloring books on Amazon! These weed-themed coloring books make …

The post 30 Best Stoner Coloring Books on Amazon appeared first on The Cannabis School.

Published

2 hours ago

January 16, 2021

Republished by Plato

We’ve put together a comprehensive list of the 30 best stoner coloring books on Amazon! These weed-themed coloring books make for a fun activity that helps spark your creativity and imagination. Each coloring book found below will have a direct link to it’s listing on Amazon, this will help you easily view or purchase it. Activities like this help enhance the cannabis experience by allowing the user to concentrate on a fun task. The level of your visual indulgence during your “high” is important in determining how much you’ll enjoy it. In other words, what better tools for meditation and recreation than cannabis and coloring?

The condensed list below contains the links to all the best stoner coloring books found in this article:

Condensed List:

Red, glossy eyes are the trademark of a good high. This stoner coloring book features 25 hand-drawn stoner designs for you to color. With 50 pages in total, you don’t even have to worry about ruining the next page’s design with your color’s tint.

It comes in two price variants, $7.99 for paperback and $20.49 for a spiral bound book, perfect for gifts! Oh and it has a free PDF inside too!

Product Features:

25 unique designs
50 single side printing on both white and black papers
Available in paperback and spiral bound variants
Free PDF!

If you liked this, check out a similar one below:

Price: $4.99

Get your hands on this humorous coloring book which includes 17 unique designs and “black light” versions of 15 of them, making a total of 33 pages to color!

Product Features:

66 total pages with 33 single-side printed pages to color
17 unique designs
Glossy paper
Suitable for pencil colours, markers, pens and crayons

With the title inspired by the Netflix hit show “Stranger Things”, this is a perfect gift for fans of the show! The book includes 16 unique designs and also includes inverted background versions for many of them. One of the best stoner coloring books.

Product Features:

31 pages to colour
16 unique designs
Glossy paper
Suitable for color pencils, pens, markers and crayons.

Not quite satisfied? Check out another “Stranger Things” inspired option below!

Calling all our stoner girls! This Disney princess inspired stoner coloring book has all your favourite Disney princess stories with a 420 twist. Now you get to reimagine all the fairytales while in your most creative state.

Product Features:

27 unique designs 54 pages in total
Single side high quality printed pages
Suitable for colouring pencils, markers, crayons etc

If you liked this theme, check out similar princess stoner colouring books below!

Disney princess stoner coloring book with two girls smoking on the cover.

Disney character stoner coloring book cover.

Another one for our Disney lovers, because who doesn’t love this dynamic six! We can already hear Donald Duck’s high quacks!

Product Features:

25 unique illustrations
High quality paper
Single side printing
8.5*11 inches size

This artistic representation of empowered women and gender fluid people who relish the herb is a wonderful gift for all the intellectual and mindful people in your friend circle. With over 60 intricate images of tattoos, marijuana bouquets, patterned garb, shape-filled backgrounds and gorgeous faces, you’ll find new meanings to life inspired by the art in this colouring book!

Product Features:

60 single-sided printed pages
High-quality paper
8.5*11 inches size
Suitable for pencil colours, crayons, markers etc.

If you liked this artistry, then check out the next similar one below!

The Trippy Chicks Coloring book features mystical women channelling their inner goddesses. Expect to find religious symbols, long locks, reptiles and mandalas.

Presenting another gift option for our stoner guys, although with designs so intricate and detailed, even the girls won’t be able to resist it. You can draw for days on end with this book, filling it with colours and creating your own psychedelic paradise.

Product Features:

Premium glossy cover
Single sided pages to avoid bleed through
8.5*11 inches size
High quality white paper

Animals smoking weed stoner coloring book with a fish on the cover smoking a joint.

From the Dinosaurs of Jurassic Park to reefer madness and game of stoned, this book is guaranteed to leave you in fits of laughter. Kristin Harris really amped up his game with this one!

Product Features:

26 unique images
Test image to try out your colors
High-quality paper
8.5*11 inches size

The Wiz Khalifa's weed farm stoner coloring book.

Wiz Khalifa is back yet again with a pro-cannabis statement in the form of his new product “The Wiz Khalifa Weed Farm Coloring Book”.

This stress-relieving coloring book is slightly on the pricier edge, going at $14.95, but is rightly so, because with featured iconic images from LA to Amsterdam and events like Danksgiving and Wiz’s Birthday, it’s a direct sneak peek into Khalifa’s weed empire!

Fresh baked stoner coloring book volume 3 edition.

The Fresh Baked series is a designer brainchild of independent artists who came together to design fun pot-themed images and humourous marijuana designs for people who like to relieve stress through coloring while high.

Product Features:

Fun cannabis inspired designs
Original images
High-quality paper
8.5*11 inches size
Part of a series of three

If you liked this, be sure to check out Fresh Baked Volume 1 and 2! A perfect gift bundle for Birthdays or Christmas!

Fresh baked stoner coloring book for weed lovers. The cover has a bong smoking a jay.

The fresh baked cannabis coloring book for weed lovers.

Marijuana strains adult coloring book cover. This cover includes a man sitting down meditating with his seven chakras.

Not all Cannabis is the same. There are a ton of varieties and so many different strains to choose from. Check out this colouring book that not only lets you have a fun time with Cannabis, but also educates you on the different varieties out there. The book has illustrations of popular strains like the Harlequin, Grape Ape, Dance World, Cherry Pie, Frankenstein, and Laughing Buddha. One of the best stoner coloring books.

So gather your friends and take turns to color and try the Cannabis varieties drawn in the book, who knows, you may find your next favourite party strain here!

Product Features:

Paperback
Unique Illustrations
Cannabis strain designs
8.5*11 inches size

Stoner coloring book jumbo edition cover, the blue background has stars shining through it.

Does your trip make you feel like a part of an alternate universe too? If so, you will love this coloring book that transports you directly into a psychedelic world.

Product Features:

30 high quality illustrations
Single side printing to avoid bleed through
8.5 x 11’’ size

If you liked this, check out similar books that also promise a great trip!

Trippy advisor the psychedelic coloring book for stoners. The cover is painted in rainbow with joints on it.

Day trip alien coloring book, made with colorful designs and shapes.

A cover for a stoner coloring book that is sold on amazon. The cover includes designs of mushrooms and fun animals.

A psychedelic coloring book for adults with a blue woman smoking a joint on the front cover.

A psychedelic coloring book made with colorful patterns and shapes.

Marijuana, meditate and contemplate: that’s our mantra. With 35 unique and beautiful kaleidoscopic designs, color in magical mushrooms and mandalas and make your trip a memorable one.

Product Features:

8.5*11 sized pages
Single-sided printing on white paper
35 unique illustrations
High quality 60lb paper

If you like coloring in Mandalas, check out these two as well:

The trippy hippie coloring book cover, including the face of a girl hippie.

Reefer madness stoner coloring book cover with a pot leaf on the front.

A stoner coloring book with a potleaf on the front smoking a joint.

We saved the absolute best for the last. Get your hands on the Stoner Activity Book that not only has coloring pages, but also crosswords, puzzles, trippy mazes and more for a variety of activities to do while high!

If you like this type of product, also check out this stoner coloring and activity book:

the cover of a Stoner coloring book, high life, by jay anthony

So there you have it! The 30 best stoner coloring books on Amazon! If you enjoyed this list, check out our article on the 30 Best Stoner Gifts on Amazon! Leave a comment with what you would like to see next!

Source: https://www.thecannaschool.ca/best-stoner-coloring-books/