Some people have made the marijuana plant unlawful. And for many, even after it is decriminalized, will still be unaccepting to the fact that is beneficial for so many ailments. It is hard for a lot for some to understand that although Hemp and Marijuana are very similar, they are very different. And the biggest difference is obviously the fact that Hemp does not produce an intoxicating ‘high’.
People also commonly falsify that they don’t need to take CBD because they smoke marijuana. Tetrahydrocannabinol, or THC, the main mind-altering chemical found in the Cannabis plant-and is more vastly more abundant in Marijuana and considerably lower in Hemp. The medicinal chemicals are Cannabinoids, not THC (however, THC can be useful for other conditions). Hemp on the other hand is very high in Cannabinoids, and very low in THC. There is not enough CBD in marijuana to be beneficial for many illnesses.
In the case of close-minded, more traditional individuals, marijuana is a drug used by lazy people to get ‘stoned’ or ‘high’, and nothing else. This while they see alcohol as an acceptable substance to use regularly. Sadly, you aren’t always able to change the minds of some folks. On the other hand, there are those who have open ears to listen, you can easily explain to them how these two plants are different and why everyone needs to take it. The way we tend to blindly take medicines today without truly considering ALL side effects is enough for me to take a look at alternative, more naturally occurring options as we awake from the ‘mental coma’ a lot of the world has put us in.
CBD is absorbed into your bloodstream, via the sublingual gland (under the tongue), through the digestive tract after consuming an edible, drink, or capsule or through the lungs while using the inhalation route. From there, all cannabinoids attach to CBD receptors throughout the whole body. The human body does produce some certain cannabinoids on its own, naturally, as well!
The receptors most commonly used by cannabinoids are called CB1 and CB2. CBD receptors are found all throughout the body and some are in the brain. They deal with movement and pain, mood and emotions, thinking and processing, memories, and other functions. THC also attach to these receptors. CB2 receptors are found in the immune system and they also affect pain and inflammation.
There are studies where scientists have discovered that cannabinoids do not actually attach themselves to the receptions, but encourages the human body to create its own!
Hemp was originally used for its broad horizon of purpose. It was used for textile and clothing, building materials such as insulation, paper, shoes, food, and so forth. In the 1960’s scientists discovered the endocannabinoid system. Unfortunately, it took until the 1990’s for scientists to start studies on the health benefits of cannabinoids. Their studies were limited due to the schedule I control status of cannabis.
Now, scientists are legally in the clear to conduct studies on Marijuana, Hemp, Cannabinoids and the benefits of them all. They have discovered thousands of contributions from CBD as well as THC. It also is a great help to have so many individuals expressing their personal improvements from taking cannabinoids.
So here we are now, years after the discovery of CBD and the Endocannabinoid System (ECS), and we are still learning everyday more benefits from the plants. It’s amazing to know that the hemp plant actually helped build our nation, and helped people thousands of years ago, and the opinion of a few beings took that away from us completely.
The public is becoming more accepting, the generations are becoming more conscious. All it takes is for someone to help open their eyes. You can contribute to the masses just by explaining the differences between the two plants, and how CBD occurs naturally in the body. I would hope that someone would do the same for me if I were unable to do the research myself, or just new to the whole concept.
Hemp is not just a bandwagon, or a phase that will air out over time. Yes, Hemp and CBD have gained an extreme amount of attention throughout the last few years, but that is only because we have access to a whole new broad spectrum of information. Scientists are doing more studies and proving more effects of CBD every day. Even doctors are starting to tell their personal opinions of CBD and how it helps. Some are going as far as sending CBD users to reputable CBD distributors.
Let us work together and make life easier for everyone. Life without pain and life without anxiety IS possible without harsh medications from pharmaceutical companies, and just a few years ago, that did not seem possible.
The Role of Cannabinoids as Anticancer Agents in Pediatric Oncology
Cannabinoids are a group of chemicals that bind to receptors in the human body and, in turn, modulate the endocannabinoid system (ECS). They can be endogenously produced, synthetic, or derived from the plant Cannabis sativa L. Research over the past several decades has shown that the ECS is a cellular communication network essential to maintain multiple biological functions and the homeostasis of the body. Indeed, cannabinoids have been shown to influence a wide variety of biological effects,…
Cannabinoids are a group of chemicals that bind to receptors in the human body and, in turn, modulate the endocannabinoid system (ECS). They can be endogenously produced, synthetic, or derived from the plant Cannabis sativa L. Research over the past several decades has shown that the ECS is a cellular communication network essential to maintain multiple biological functions and the homeostasis of the body. Indeed, cannabinoids have been shown to influence a wide variety of biological effects, including memory, pain, reproduction, bone remodeling or immunity, to name a few. Unsurprisingly, given these broad physiological effects, alterations of the ECS have been found in different diseases, including cancer. In recent years, the medical use of cannabis has been approved in different countries for a variety of human conditions. However, the use of these compounds, specifically as anticancer agents, remains controversial. Studies have shown that cannabinoids do have anticancer activity in different tumor types such as breast cancer, melanoma, lymphoma and adult brain cancer. Specifically, phytocannabinoids Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) has been shown to induce apoptosis and inhibit proliferation of adult cancer cells, as well as modulate angiogenesis and metastasis. Despite increasing evidence that cannabinoids elicit antitumor effects in adult cancers, there is minimal data available on their effects in children or in pediatric cancers despite public and clinical demand for information. Here we describe a comprehensive and critical review of what is known about the effects of cannabinoids on pediatric cancers, highlight current gaps in knowledge and identify the critical issues that need addressing before considering these promising but controversial drugs for use in pediatric oncology.
Keywords: CBD; THC; cannabidiol; cannabinoid; childhood cancer; medical cannabis; pediatric oncology; Δ9-tetrahydrocannabinol.
Cannabis sativa L. as a Natural Drug Meeting the Criteria of a Multitarget Approach to Treatment
Cannabis sativa L. turned out to be a valuable source of chemical compounds of various structures, showing pharmacological activity. The most important groups of compounds include phytocannabinoids and terpenes. The pharmacological activity of Cannabis (in epilepsy, sclerosis multiplex (SM), vomiting and nausea, pain, appetite loss, inflammatory bowel diseases (IBDs), Parkinson’s disease, Tourette’s syndrome, schizophrenia, glaucoma, and coronavirus disease 2019 (COVID-19)), which has been…
Cannabis sativa L. turned out to be a valuable source of chemical compounds of various structures, showing pharmacological activity. The most important groups of compounds include phytocannabinoids and terpenes. The pharmacological activity of Cannabis (in epilepsy, sclerosis multiplex (SM), vomiting and nausea, pain, appetite loss, inflammatory bowel diseases (IBDs), Parkinson’s disease, Tourette’s syndrome, schizophrenia, glaucoma, and coronavirus disease 2019 (COVID-19)), which has been proven so far, results from the affinity of these compounds predominantly for the receptors of the endocannabinoid system (the cannabinoid receptor type 1 (CB1), type two (CB2), and the G protein-coupled receptor 55 (GPR55)) but, also, for peroxisome proliferator-activated receptor (PPAR), glycine receptors, serotonin receptors (5-HT), transient receptor potential channels (TRP), and GPR, opioid receptors. The synergism of action of phytochemicals present in Cannabis sp. raw material is also expressed in their increased bioavailability and penetration through the blood-brain barrier. This review provides an overview of phytochemistry and pharmacology of compounds present in Cannabis extracts in the context of the current knowledge about their synergistic actions and the implications of clinical use in the treatment of selected diseases.
Keywords: Cannabis; multitarget; phytocannabinoids (THC and CBD); receptors; terpenes.
Pervasive cropland in protected areas highlight trade-offs between conservation and food security
Global cropland expansion over the last century caused widespread habitat loss and degradation. Establishment of protected areas aims to counteract the loss of habitats and to slow species extinctions. However, many protected areas also include high levels of habitat disturbance and conversion for uses such as cropland. Understanding where and why this occurs may realign conservation priorities and inform protected area policy in light of competing priorities such as food security. Here, we use…
Global cropland expansion over the last century caused widespread habitat loss and degradation. Establishment of protected areas aims to counteract the loss of habitats and to slow species extinctions. However, many protected areas also include high levels of habitat disturbance and conversion for uses such as cropland. Understanding where and why this occurs may realign conservation priorities and inform protected area policy in light of competing priorities such as food security. Here, we use our global synthesis cropland dataset to quantify cropland in protected areas globally and assess their relationship to conservation aims and socio-environmental context. We estimate that cropland occupies 1.4 million km2 or 6% of global protected area. Cropland occurs across all protected area management types, with 22% occurring in strictly protected areas. Cropland inside protected areas is more prevalent in countries with higher population density, lower income inequality, and with higher agricultural suitability of protected lands. While this phenomenon is dominant in midnorthern latitudes, areas of cropland in protected areas of the tropics and subtropics may present greater trade-offs due to higher levels of both biodiversity and food insecurity. Although area-based targets are prominent in biodiversity goal-setting, our results show that they can mask persistent anthropogenic land uses detrimental to native ecosystem conservation. To ensure the long-term efficacy of protected areas, post-2020 goal setting must link aims for biodiversity and human health and improve monitoring of conservation outcomes in cropland-impacted protected areas.
Keywords: CBD; area-based targets; conservation; food security; protected areas.
Conflict of interest statement
The authors declare no competing interest.
- Klein Goldewijk K., Beusen A., Doelman J., Stehfest E.. New anthropogenic land use estimates for the holocene: HYDE 3.2. Earth Syst. Sci. Data. 2017;9:927–953.
- Barrett C. B.. Measuring food insecurity. Science. 2010;327:825–828.
- Fogel R. W.. The Escape from Hunger and Premature Death, 1700-2100: Europe, America, and the Third World. 2004.
- Crist E., Mora C., Engelman R.. The interaction of human population, food production, and biodiversity protection. Science. 2017;356:260–264.
- Pimm S. L., Vijay V.. Population, Agriculture, and Biodiversity: Problems and Prospects. 2020;365.
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