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Hemp seed/evening primrose oil affects expression of STAT3, IL-17, and FOXP3(+) in experimental autoimmune encephalomyelitis

T helper (Th)-17 mediate inflammation in both peripheral tissues and the central nervous system. Signal transducer and activator of transcription factor3 (STAT3) is required for Th-cell pathogenicity and its activation in the brain has been demonstrated during the acute phase of experimental autoimmune encephalomyelitis (EAE) through the mammalian target of rapamycin (mTOR) signaling. Rapamycin (RAPA), an inhibitor of mTOR, can drive Forkhead box P3 (FOXP3^(+)) induction as a regulatory factor….

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Fig. 2

Pathological analysis of the spinal cord sections. Group A, RAPA + HSO/EPO-treated mice showed (A1) infiltration of inflammatory cells, (A2,3) vacuolation, spongy lesions, and extensive demyelination; Group B, rapamycin-treated mice showed (B1) numerous inflammatory cells, (B2,3) spongiotic zones and demyelination; extensive demyelination; Group C, HSO/EPO-treated mice showed (C1), a few inflammatory cells and (C2,3) without spongy lesions and demyelination; Group D, EAE control mice showed (D1) severe infiltration of numerous immune cells and, (D2,3) extensive vacuolation, zones of spongy degeneration, and demyelination; Group E, in the section of E1-3 from naive mice exhibiting no clinical signs. The first row was stained with H&E, the second and third rows were stained with LFB; F, histological score: 0 = no pathologic presentation, 1 = no tissue damage but minor inflammation, 2 = modest inflammation, prime tissue damage and demyelination, 3 = moderate tissue damage (demyelination, neuronal loss, tissue damage, cell death, neuronal vacuolation, and neuronophagia), 4 = necrosis (loss of all tissue elements entirely with associated cellular remains). Data are presented as mean ± SEM. *Indicates significant differences between corresponding groups (P ≤ 0.05). EAE, experimental autoimmune encephalomyelitis; HSO/EPO, hemp seed oil/evening primrose oil; RAPA, rapamycin; H&E, hematoxylin and eosin; LFB, luxol fast blue.

Source: https://pubmed.ncbi.nlm.nih.gov/31620191/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1lg0RU4SkRVNqPFA7e6OZattw-Uzcw0dBEajJBQqmhHlNZ8MdX&fc=20200804212534&ff=20200812123210&v=2.11.5

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Republished by Plato

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Republished by Plato

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