Connect with us

Metal

Hair protein delivers golden opportunities for nanoclusters


Schematic representing the keratin-templated formation of the gold nanoclusters, modification with silver and gadolinium, loading with drug and imaging by near-infrared light or magnetic resonance
Schematic representing the keratin-templated formation of the gold nanoclusters, modification with silver and gadolinium, loading with drug and imaging by near-infrared light or magnetic resonance

Keratin, the main protein in hair, is surprisingly useful for assembling gold atoms into fluorescent nanoclusters that may help deliver drugs to their targets and image diseased tissues for diagnosis.

Guang Yang at Donghua University in Shanghai and her team report on the self-assembly of keratin-templated gold nanoclusters in the journal Acta Biomaterialia. The nanoclusters were also modified to develop enhanced fluorescence and stability.

To form a nanocluster, gold atoms must be induced to assemble into collections only several nanometres wide. Many research teams have used various proteins as effective templates encouraging cluster formation, but researchers continue to seek more effective protein templates to make clusters with improved properties.

The protein keratin has a unique structure, due to the presence of many chemical bonds between sulfur atoms (disulfide bonds) on neighbouring strands of the protein molecular chains. These bonds help give keratin the strength to build hair, nails, feathers and other strong tissues in animals.

“This unique structure inspired us to explore ways to synthesize an assembly of gold nanoclusters,” says Yang.

The researchers extracted keratin from feathers and mixed it with a solution of a gold-containing compound. After a few simple chemical treatments, the mixture yielded gold nanoclusters combined with keratin.

The nanoclusters fluoresced brightly when stimulated with near-infrared radiation. This has the range wavelengths that can penetrate into the body, a region known as the therapeutic window.

Adding silver ions produced modified nanoclusters with more than six times greater fluorescence. The researchers made a third type of nanocluster by adding ions of the metal gadolinium. This form proved to be particularly suitable for detection by magnetic resonance imaging.

Studies in mice indicated that the nanoclusters showed good biocompatibility.

Fluorescent nanoparticles, including metallic nanoclusters, are being applied widely in biomedical imaging applications. They can be used to reveal and monitor the cells and tissues that they are directly introduced to, or which they can be made to bind with and enter. Coating nanoparticles with antibodies, for example, can allow them to selectively bind to and enter chosen cells and tissues, including cancers.

Yang expects the excellent fluorescent intensity, stability and biocompatibility of the gold nanoclusters could assist in many such imaging applications.

To explore potential uses in drug delivery, the researchers loaded the gadolinium-modified nanoclusters with the anticancer drug doxorubicin. They found that the drug was effectively released in chemical conditions mimicking those of a tumour. This effect, which they attributed to the response of the disulfide bonds in the keratin, suggests opportunities for selective drug delivery into tumours.

Tests on live mice confirmed the anti-cancer potential of the gadolinium-modified nanoclusters. Fourteen days after commencing treatment, tumours growing in treated mice were less than half the volume of those in untreated controls.

 “Keratin has not received much attention for a long time,” Yang says, pointing out that she believes this protein may offer further opportunities for her group and others to explore.

Article details:

Yang, G. et al.: “The assembly of protein-templated gold nanoclusters for enhanced fluorescence emission and multifunctional applications,” Acta Biomaterialia (2020)

Acta Biomaterialia is part of the family of Acta Materialia Inc journals, which also includes Acta Materialia, Scripta Materialia and the newly launched Materialia.

Republished by Plato

Published

on


Schematic representing the keratin-templated formation of the gold nanoclusters, modification with silver and gadolinium, loading with drug and imaging by near-infrared light or magnetic resonance
Schematic representing the keratin-templated formation of the gold nanoclusters, modification with silver and gadolinium, loading with drug and imaging by near-infrared light or magnetic resonance

Keratin, the main protein in hair, is surprisingly useful for assembling gold atoms into fluorescent nanoclusters that may help deliver drugs to their targets and image diseased tissues for diagnosis.

Guang Yang at Donghua University in Shanghai and her team report on the self-assembly of keratin-templated gold nanoclusters in the journal Acta Biomaterialia. The nanoclusters were also modified to develop enhanced fluorescence and stability.

To form a nanocluster, gold atoms must be induced to assemble into collections only several nanometres wide. Many research teams have used various proteins as effective templates encouraging cluster formation, but researchers continue to seek more effective protein templates to make clusters with improved properties.

The protein keratin has a unique structure, due to the presence of many chemical bonds between sulfur atoms (disulfide bonds) on neighbouring strands of the protein molecular chains. These bonds help give keratin the strength to build hair, nails, feathers and other strong tissues in animals.

“This unique structure inspired us to explore ways to synthesize an assembly of gold nanoclusters,” says Yang.

The researchers extracted keratin from feathers and mixed it with a solution of a gold-containing compound. After a few simple chemical treatments, the mixture yielded gold nanoclusters combined with keratin.

The nanoclusters fluoresced brightly when stimulated with near-infrared radiation. This has the range wavelengths that can penetrate into the body, a region known as the therapeutic window.

Adding silver ions produced modified nanoclusters with more than six times greater fluorescence. The researchers made a third type of nanocluster by adding ions of the metal gadolinium. This form proved to be particularly suitable for detection by magnetic resonance imaging.

Studies in mice indicated that the nanoclusters showed good biocompatibility.

Fluorescent nanoparticles, including metallic nanoclusters, are being applied widely in biomedical imaging applications. They can be used to reveal and monitor the cells and tissues that they are directly introduced to, or which they can be made to bind with and enter. Coating nanoparticles with antibodies, for example, can allow them to selectively bind to and enter chosen cells and tissues, including cancers.

Yang expects the excellent fluorescent intensity, stability and biocompatibility of the gold nanoclusters could assist in many such imaging applications.

To explore potential uses in drug delivery, the researchers loaded the gadolinium-modified nanoclusters with the anticancer drug doxorubicin. They found that the drug was effectively released in chemical conditions mimicking those of a tumour. This effect, which they attributed to the response of the disulfide bonds in the keratin, suggests opportunities for selective drug delivery into tumours.

Tests on live mice confirmed the anti-cancer potential of the gadolinium-modified nanoclusters. Fourteen days after commencing treatment, tumours growing in treated mice were less than half the volume of those in untreated controls.

 “Keratin has not received much attention for a long time,” Yang says, pointing out that she believes this protein may offer further opportunities for her group and others to explore.

Article details:

Yang, G. et al.: “The assembly of protein-templated gold nanoclusters for enhanced fluorescence emission and multifunctional applications,” Acta Biomaterialia (2020)

Acta Biomaterialia is part of the family of Acta Materialia Inc journals, which also includes Acta Materialia, Scripta Materialia and the newly launched Materialia.

Source: https://www.materialstoday.com/biomaterials/features/hair-protein-delivers-for-nanoclusters/

Metal

Daily iron ore prices CFR China – March 2, 2021

Republished by Plato

Published

on

Information Provided By:

SteelOrbis Elektronik Pazaryeri A.Ş. (“SteelOrbis”)
19 Mayıs Mahallesi, Atatürk Caddesi
Şeref Yazgan İş Merkezi, No: 72, Kat: 7, D: 18
Kozyatağı – 34736
Istanbul, Turkey

Trade Registration Number : 541892
MERSİS Number : 0470048178400014
Customer Relations Officer : Sinem Alpkaya
Tel : +90 216 468 10 50
Fax : +90 216 386 41 08

This Information Form has been drawn up in order to provide information to the customer (“Customer”) who seeks a free trial on an electronic environment for the purpose of benefiting from the services offered by the SteelOrbis website at “www.steelorbis.com” prior to acceptance of the Membership Contract, and it allows the Customer to gain clear information on the terms and conditions of the membership to be established as well as to review the text of the Contract in question.

The following successive steps shall be taken in order to establish a free trial:

– The Customer selects the “Free Trial” option on the home page at https://www.steelorbis.com.
– The Customer provides all information requested in the “Free Trial Application” form displayed on the screen and confirms it.
– SteelOrbis sends an account activation e-mail to the e-mail address of the Customer provided in the application form.
– The Customer clicks on the activation link sent to his/her e-mail address and activates his/her account. The website Membership Contract is presented to the Customer during the account activation process.

Storage of the Membership Contract:

You can either save the Membership Contract on your computer or make print-outs of it for storage. The Membership Contract accepted and confirmed by the Customer is not kept by SteelOrbis. You can always get access to the standard Membership Contract displayed on the website. However, as amendments may be made to the standard Contract, it may include some variations in comparison with the text approved by you. Accordingly, it may not be possible for you to access on the website the text you originally approved.

Data entry errors:

The information you should provide for membership application and the fields you should fill in are indicated during each step of the operation. You are obliged to provide such information. If you leave the required fields blank, the system will issue a warning. Please fill in all necessary fields. Prior to the completion of the operation, all data entered by you in the previous step will be displayed once more. Please make sure that the information provided by you is accurate and complete before finally confirming the operation; any missing or incorrect information should be completed or corrected. Any amendment or correction on the information provided by you after the confirmation may be performed by means of website logins after the establishment of the membership.

Our confidentiality policy:

Please click here to review our confidentiality policy.

Checkout PrimeXBT
Trade with the Official CFD Partners of AC Milan
Source: https://www.steelorbis.com/steel-prices/steel-prices-market-analyses/scrap-and-raw-materials/daily-iron-ore-prices-cfr-china-_-march-2-2021-1188595.htm

Continue Reading

Metal

Turkey’s CRC prices pushed up further by limited supply, active demand

Turkey-based re-rollers have been enjoying improving demand for their products, specifically in the cold rolled coil (CRC) segment.

Republished by Plato

Published

on

Information Provided By:

SteelOrbis Elektronik Pazaryeri A.Ş. (“SteelOrbis”)
19 Mayıs Mahallesi, Atatürk Caddesi
Şeref Yazgan İş Merkezi, No: 72, Kat: 7, D: 18
Kozyatağı – 34736
Istanbul, Turkey

Trade Registration Number : 541892
MERSİS Number : 0470048178400014
Customer Relations Officer : Sinem Alpkaya
Tel : +90 216 468 10 50
Fax : +90 216 386 41 08

This Information Form has been drawn up in order to provide information to the customer (“Customer”) who seeks a free trial on an electronic environment for the purpose of benefiting from the services offered by the SteelOrbis website at “www.steelorbis.com” prior to acceptance of the Membership Contract, and it allows the Customer to gain clear information on the terms and conditions of the membership to be established as well as to review the text of the Contract in question.

The following successive steps shall be taken in order to establish a free trial:

– The Customer selects the “Free Trial” option on the home page at https://www.steelorbis.com.
– The Customer provides all information requested in the “Free Trial Application” form displayed on the screen and confirms it.
– SteelOrbis sends an account activation e-mail to the e-mail address of the Customer provided in the application form.
– The Customer clicks on the activation link sent to his/her e-mail address and activates his/her account. The website Membership Contract is presented to the Customer during the account activation process.

Storage of the Membership Contract:

You can either save the Membership Contract on your computer or make print-outs of it for storage. The Membership Contract accepted and confirmed by the Customer is not kept by SteelOrbis. You can always get access to the standard Membership Contract displayed on the website. However, as amendments may be made to the standard Contract, it may include some variations in comparison with the text approved by you. Accordingly, it may not be possible for you to access on the website the text you originally approved.

Data entry errors:

The information you should provide for membership application and the fields you should fill in are indicated during each step of the operation. You are obliged to provide such information. If you leave the required fields blank, the system will issue a warning. Please fill in all necessary fields. Prior to the completion of the operation, all data entered by you in the previous step will be displayed once more. Please make sure that the information provided by you is accurate and complete before finally confirming the operation; any missing or incorrect information should be completed or corrected. Any amendment or correction on the information provided by you after the confirmation may be performed by means of website logins after the establishment of the membership.

Our confidentiality policy:

Please click here to review our confidentiality policy.

Checkout PrimeXBT
Trade with the Official CFD Partners of AC Milan
Source: https://www.steelorbis.com/steel-prices/steel-prices-market-analyses/flats-and-slab/turkeys-crc-prices-pushed-up-further-by-limited-supply-active-demand-1188561.htm

Continue Reading

Metal

Slab prices in Asia higher, but demand still not strong

Prices for imported slabs in Asia have improved over the past week, supported by the uptrend in the flat steel segment, for HRC in particular.

Republished by Plato

Published

on

Information Provided By:

SteelOrbis Elektronik Pazaryeri A.Ş. (“SteelOrbis”)
19 Mayıs Mahallesi, Atatürk Caddesi
Şeref Yazgan İş Merkezi, No: 72, Kat: 7, D: 18
Kozyatağı – 34736
Istanbul, Turkey

Trade Registration Number : 541892
MERSİS Number : 0470048178400014
Customer Relations Officer : Sinem Alpkaya
Tel : +90 216 468 10 50
Fax : +90 216 386 41 08

This Information Form has been drawn up in order to provide information to the customer (“Customer”) who seeks a free trial on an electronic environment for the purpose of benefiting from the services offered by the SteelOrbis website at “www.steelorbis.com” prior to acceptance of the Membership Contract, and it allows the Customer to gain clear information on the terms and conditions of the membership to be established as well as to review the text of the Contract in question.

The following successive steps shall be taken in order to establish a free trial:

– The Customer selects the “Free Trial” option on the home page at https://www.steelorbis.com.
– The Customer provides all information requested in the “Free Trial Application” form displayed on the screen and confirms it.
– SteelOrbis sends an account activation e-mail to the e-mail address of the Customer provided in the application form.
– The Customer clicks on the activation link sent to his/her e-mail address and activates his/her account. The website Membership Contract is presented to the Customer during the account activation process.

Storage of the Membership Contract:

You can either save the Membership Contract on your computer or make print-outs of it for storage. The Membership Contract accepted and confirmed by the Customer is not kept by SteelOrbis. You can always get access to the standard Membership Contract displayed on the website. However, as amendments may be made to the standard Contract, it may include some variations in comparison with the text approved by you. Accordingly, it may not be possible for you to access on the website the text you originally approved.

Data entry errors:

The information you should provide for membership application and the fields you should fill in are indicated during each step of the operation. You are obliged to provide such information. If you leave the required fields blank, the system will issue a warning. Please fill in all necessary fields. Prior to the completion of the operation, all data entered by you in the previous step will be displayed once more. Please make sure that the information provided by you is accurate and complete before finally confirming the operation; any missing or incorrect information should be completed or corrected. Any amendment or correction on the information provided by you after the confirmation may be performed by means of website logins after the establishment of the membership.

Our confidentiality policy:

Please click here to review our confidentiality policy.

Checkout PrimeXBT
Trade with the Official CFD Partners of AC Milan
Source: https://www.steelorbis.com/steel-prices/steel-prices-market-analyses/flats-and-slab/slab-prices-in-asia-higher-but-demand-still-not-strong-1188581.htm

Continue Reading
Heartland3 days ago

CBD Vape Oil Market 2021: Global Trends, Business Overview, Challenges, Opportunities …

Heartland4 days ago

Industrial Hemp in Automotive Market Estimated Forecast Analysis 2021-2030

Material3 days ago

Microstructure, characterization of interfacial phases and mechanical properties of high Nb–TiAl/Al2O3 joints brazed by novel Nb particle-reinforced Ag–Cu filler alloy

Heartland5 days ago

Heartland5 days ago

Heartland3 days ago

Drew Carey CBD – How Does It Work For Body Pain

Heartland4 days ago

National Hemp Association Awards First Recipients of Social Equity Conscious Business (SECB …

Heartland5 days ago

Heartland5 days ago

8 of the best cannabis gummies to try right now

Heartland4 days ago

Heartland5 days ago

Uncategorized5 days ago

The Daily Hit: The February 25th, 2021

Heartland5 days ago

Uncategorized4 days ago

GW Pharmaceuticals receives positive CHMP opinion for EPIDYOLEX® (cannabidiol) for use as treatment of seizures associated with Tuberous Sclerosis Complex

Heartland4 days ago

Heartland5 days ago

Uncategorized4 days ago

Everything You Need to Know About CBD Lotion For Pain Relief

Material4 days ago

Size effect on the high strain rate micro/meso-tensile behaviors of pure titanium foil

Heartland4 days ago

Cannabis and the Autistic Spectrum

Heartland4 days ago

Heartland3 days ago

Natures Method CBD Gummies : How To Order & Basic Price Detail?

Heartland3 days ago

Hemp a budding industry in New Mexico

Heartland2 days ago

Hello, im new to CBD and I just got this e-liquid and a pen. I looked up the vape juice after, and it doesn’t seem to exist.. Has anyone else used this brand?

Heartland1 day ago

Top 5 reasons people use CBD tinctures

Metal5 days ago

US tin plate exports down 32.2 percent in December

Manufacturing5 days ago

USTR Nominee Katherine Tai Says She Wants to Make Sure Trade “Works for Our Workers”

Manufacturing5 days ago

A question on manufacturing electronics at a production level…

Heartland5 days ago

Bloom Farms Sport Stick

Heartland5 days ago

Heartland5 days ago

Should I purchase extract labs CBD Oil?

Trending

A Cloud Nine Capital Entity Copyright © 2020 – All Rights Reserved Proudly Made in America