Connect with us

Heartland

Frontal Alpha Asymmetry and Inhibitory Control among Individuals with Cannabis Use Disorders

To better understand the biopsychosocial mechanisms associated with development and maintenance of cannabis use disorder (CUD), we examined frontal alpha asymmetry (FAA) as a measure of approach bias and inhibitory control in cannabis users versus healthy nonusers. We investigated: (1) whether FAA could distinguish cannabis users from healthy controls; (2) whether there are cue-specific FAA effects in cannabis users versus controls; and (3) the time course of cue-specific approach motivation and…

Republished by Plato

Published

on


. 2019 Aug 29;9(9):219.

doi: 10.3390/brainsci9090219.

Affiliations

Free PMC article

Item in Clipboard

Alina Shevorykin et al. Brain Sci. .

Free PMC article

Abstract

To better understand the biopsychosocial mechanisms associated with development and maintenance of cannabis use disorder (CUD), we examined frontal alpha asymmetry (FAA) as a measure of approach bias and inhibitory control in cannabis users versus healthy nonusers. We investigated: (1) whether FAA could distinguish cannabis users from healthy controls; (2) whether there are cue-specific FAA effects in cannabis users versus controls; and (3) the time course of cue-specific approach motivation and inhibitory control processes. EEG data were analyzed from forty participants (CUD (n = 20) and controls (n = 20)) who completed a modified visual attention task. Results showed controls exhibited greater relative right hemisphere activation (indicating avoidance/withdrawal motivation) when exposed to cannabis cues during the filtering task. By contrast, cannabis users exhibited greater relative left activation (approach) to all cues (cannabis, positive, negative, and neutral), reflecting a generalized approach motivational tendency, particularly during later stages of inhibitory control processes. The difference between cannabis users and controls in FAA was largest during mid- to late processing stages of all cues, indicating greater approach motivation during later stages of information processing among cannabis users. Findings suggest FAA may distinguish cannabis users from healthy controls and shows promise as a measure of inhibitory control processes in cannabis users.

Keywords: EEG; cannabinoids; cannabis use disorder; craving; cue reactivity; frontal alpha asymmetry; inhibitory control.

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1

Figure 1

Modified flanker task, made up of a block of 80 trials, each consisting of a fixation square followed by the first flanker, target, and second flanker (stimulus displays), presented sequentially for 150 ms separated by a random interstimulus interval (153–390 ms). The target was represented by a vertical or horizontal line, or a cross superimposed on a cannabis-related picture or a neutral, positive, or negative image from the International Affective Picture System (IAPS) [42].

Figure 2

Figure 2

A significant three-way interaction of task (baseline vs. filtering), cue (cannabis, neutral, positive, and negative) and frequency (8–13 Hz) on frontal alpha asymmetry. Larger task difference at low alpha was especially prominent to cannabis cues relative to neutral, positive, and negative cues. Error bars represent the standard error of the mean.

Figure 3

Figure 3

A significant four-way interaction in group (cannabis users vs. controls), task (baseline vs. filtering), cues (cannabis vs. neutral) and frequency (8–13 Hz) on frontal alpha asymmetry. Control participants show right-sided hemisphere (avoidance) frontal alpha asymmetry (FAA) activation only to cannabis cues during the filtering task, and they show left-sided (positive) activation in the other conditions, while cannabis users show left-sided activation (approach) in all conditions. Error bars represent the standard error of the mean.

Figure 4

Figure 4

Group difference (cannabis users vs. controls) in FAA. The largest group difference was during the middle and late time epochs. Error bars represent the standard error of the mean. See the online article for the color version of this figure.

Similar articles

Cited by 1 article

References

    1. Azofeifa A., Schauer G., McAfee T., Grant A., Lyerla R., Mattson M.E. National Estimates of Marijuana Use and Related Indicators—National Survey on Drug Use and Health, United States, 2002–2014. MMWR Surveill. Summ. 2016;65:1–28. doi: 10.15585/mmwr.ss6511a1. – DOI PubMed
    1. Carliner H., Brown Q.L., Sarvet A.L., Hasin D.S. Cannabis use, attitudes, and legal status in the U.S.: A review. Prev. Med. 2017;104:13–23. doi: 10.1016/j.ypmed.2017.07.008. – DOI PMC PubMed
    1. Okaneku J., Vearrier D., McKeever R.G., LaSala G.S., Greenberg M.I. Change in perceived risk associated with marijuana use in the United States from 2002 to 2012. Clin. Toxicol. 2015;53:151–155. doi: 10.3109/15563650.2015.1004581. – DOI PubMed
    1. Volkow N.D., Baler R.D., Compton W.M., Susan R.B. Adverse Health Effects of Marijuana Use. N. Engl. J. Med. 2016;370:2219–2227. doi: 10.1056/NEJMra1402309. – DOI PMC PubMed
    1. Volkow N.D., Swanson J.M., Evins A.E., DeLisi L.E., Meier M.H., González R., Bloomfield M.A.P., Curran H.V., Baler R. Effects of Cannabis Use on Human Behavior, Including Cognition, Motivation, and Psychosis: A Review. JAMA Psychiatry. 2016;73:292–297. doi: 10.1001/jamapsychiatry.2015.3278. – DOI PubMed

Grant support

LinkOut – more resources

  • Full Text Sources

  • Research Materials

  • Miscellaneous

Source: https://pubmed.ncbi.nlm.nih.gov/31470590/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1lg0RU4SkRVNqPFA7e6OZattw-Uzcw0dBEajJBQqmhHlNZ8MdX&fc=20200804212534&ff=20200813015344&v=2.11.5

Heartland

Growth of Cannabidiol Oil (CBD Oil) Market Size Report Till 2025

Republished by Plato

Published

on

The Global Cannabidiol Oil (CBD Oil) Market covers explicit information regarding the development rate, market estimates, drivers, limitations, future … Source:

Continue Reading

Heartland

Hemp Seed Market Explosive Factors of Revenue by Major Manufacturers |Hempco Inc, Ecofibre …

Republished by Plato

Published

on

Hemp Seed Market research report is the high quality report having in-depth market research studies. This market report provides best solutions for … Source:

Continue Reading

Heartland

CBD Oil Market 2021 Global Industry Size, Reviews, Segments, Revenue, and Forecast to 2027

Republished by Plato

Published

on

Fort Collins, Colorado: The most recently published CBD Oil Market report provides a critical assessment of key growth dynamics, emerging pathways, … Source:

Continue Reading
Heartland1 day ago

CBD Vape Oil Market 2021: Global Trends, Business Overview, Challenges, Opportunities …

Heartland4 days ago

Uncategorized4 days ago

What CBD Oil is Right For Me?

Heartland4 days ago

Heartland3 days ago

Heartland4 days ago

Registration opens for consumable hemp manufacturers and retailers

Heartland4 days ago

CBD Oil for Beginners

Heartland4 days ago

CBP Can't Block Parts Imports, Hemp Machinery Co. Says

Heartland3 days ago

8 of the best cannabis gummies to try right now

Heartland2 days ago

National Hemp Association Awards First Recipients of Social Equity Conscious Business (SECB …

Heartland2 days ago

Industrial Hemp in Automotive Market Estimated Forecast Analysis 2021-2030

Heartland5 days ago

Interactions between CBD and hormonal contraception

Metal5 days ago

Pakistani CRC and HDG producers raise prices on higher input costs

Heartland4 days ago

CBD Skincare Products Are Popping Up Everywhere — But Do They Actually Work?

Heartland4 days ago

Sunnyvale Labs CBD Gummies — Instant Pain Relief Hemp Gummies!

Heartland4 days ago

Heartland3 days ago

Heartland4 days ago

Material4 days ago

IMC microstructure modification and mechanical reinforcement of Sn–Ag–Cu/Cu microelectronic joints through an advanced surface finish technique

Heartland4 days ago

Hemp Is Creating an EcoRevolution

Heartland4 days ago

CBD to combat physcoactive properties in THC

Heartland5 days ago

12 Ways CBD products can Improve your Health and Wellbeing – 2021 Review

Heartland5 days ago

Former Eaze CEO Pleads Guilty In Bank Fraud Case

Material4 days ago

A new approach of predicting dynamic recrystallization using directly a flow stress model and its application to medium Mn steel

Heartland4 days ago

Acreage Holdings to Sell Florida Cannabis Operations to Red White & Bloom for $60 Million

Heartland4 days ago

Uncategorized3 days ago

The Daily Hit: The February 25th, 2021

Material2 days ago

Microstructure, characterization of interfacial phases and mechanical properties of high Nb–TiAl/Al2O3 joints brazed by novel Nb particle-reinforced Ag–Cu filler alloy

Heartland2 days ago

Drew Carey CBD – How Does It Work For Body Pain

Heartland5 days ago

Growing Popularity of Cannabidiol Cbd Market Share by Top Manufacturers ENDOCA, CBD

Trending

A Cloud Nine Capital Entity Copyright © 2020 – All Rights Reserved Proudly Made in America