Connect with us

Heartland

Early Phase in the Development of Cannabidiol as a Treatment for Addiction: Opioid Relapse Takes Initial Center Stage

Multiple cannabinoids derived from the marijuana plant have potential therapeutic benefits but most have not been well investigated, despite the widespread legalization of medical marijuana in the USA and other countries. Therapeutic indications will depend on determinations as to which of the multiple cannabinoids, and other biologically active chemicals that are present in the marijuana plant, can be developed to treat specific symptoms and/or diseases. Such insights are particularly critical…

Republished by Plato

Published

on

Multiple cannabinoids derived from the marijuana plant have potential therapeutic benefits but most have not been well investigated, despite the widespread legalization of medical marijuana in the USA and other countries. Therapeutic indications will depend on determinations as to which of the multiple cannabinoids, and other biologically active chemicals that are present in the marijuana plant, can be developed to treat specific symptoms and/or diseases. Such insights are particularly critical for addiction disorders, where different phytocannabinoids appear to induce opposing actions that can confound the development of treatment interventions. Whereas Δ(9)-tetracannabinol has been well documented to be rewarding and to enhance sensitivity to other drugs, cannabidiol (CBD), in contrast, appears to have low reinforcing properties with limited abuse potential and to inhibit drug-seeking behavior. Other considerations such as CBD’s anxiolytic properties and minimal adverse side effects also support its potential viability as a treatment option for a variety of symptoms associated with drug addiction. However, significant research is still needed as CBD investigations published to date primarily relate to its effects on opioid drugs, and CBD’s efficacy at different phases of the abuse cycle for different classes of addictive substances remain largely understudied. Our paper provides an overview of preclinical animal and human clinical investigations, and presents preliminary clinical data that collectively sets a strong foundation in support of the further exploration of CBD as a therapeutic intervention against opioid relapse. As the legal landscape for medical marijuana unfolds, it is important to distinguish it from “medical CBD” and other specific cannabinoids, that can more appropriately be used to maximize the medicinal potential of the marijuana plant.

Keywords: Cannabis; Craving; Heroin; Human; Rat; THC.

Source: https://pubmed.ncbi.nlm.nih.gov/26269227/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1z7zlNEMzQex5jriqkhCblNtckSEpT9xYlxxeymU_73UTETESY&fc=20200804213258&ff=20200811034526&v=2.11.5

Heartland

Looking for something to help with my…everything

Republished by Plato

Published

on

I have a laundry list of conditions, both physical and mental. I am looking at a few different types of CBD, namely vape juices and flowers. I am looking for strains that help with anxiety, depression, insomnia, PTSD, mood swings, and nerve and joint pain. I take medication for all of these things, but these conditions still plague my life. Are there any specific strains or flowers I should be looking at?

Source: https://www.reddit.com/r/CBD/comments/l4icle/looking_for_something_to_help_with_myeverything/

Continue Reading

Heartland

Recipes for making CBD Flower into gummies?

Republished by Plato

Published

on

My wife uses the CBD flower and I was thinking about making her flower into gummies. A friend of her gave her 2 ounces of flower, but that’s way too much for her to use before it goes bad. I tried googling some stuff but it’s all pretty confusing and it was like factory production of CBD. Any info this group may have will be very helpful!

Source: https://www.reddit.com/r/CBD/comments/l4gnwh/recipes_for_making_cbd_flower_into_gummies/

Continue Reading

Heartland

New T5 strain from Roots and Herb Farm

Republished by Plato

Published

on

Visit our community site for vetted suppliers at http://theCBD.place. It’s time that this subject was given more internet exposure. We are here to discuss topics related to medical marijuana and our experiences using CBD. Please do not assume that anyone here is a medical professional.

Source: https://www.reddit.com/r/CBD/comments/l4gjgf/new_t5_strain_from_roots_and_herb_farm/

Continue Reading
News4 days ago

Jay-Z Announces Launch of Investment Fund To Aid Minority Cannabis Entrepreneurs

Heartland2 days ago

Looking for something similar to FEALS but less pricey.

Heartland3 days ago

A Permanent solution to the import impasse on children’s CBD-based medication has emerged with the Dutch manufacturer set to see the medicines made in the UK

Heartland5 days ago

MagicMed: Bringing the Drug Candidate Library Model to Psychedelics

News3 days ago

Florida Lawmakers Pushing For Cannabis Law Changes And Reform

Heartland4 days ago

New Wave Welcomes Iman Nevab, Homeopathic Research Expert to the Scientific Advisory Board

Heartland3 days ago

Topical CBD feels amazing

Heartland4 days ago

10 Herbs That Can Help With Sleep

Heartland4 days ago

Anybody ever bought from highkind? Review?

Heartland5 days ago

Canopy Animal Health Pet CBD Products Awarded NASC Quality Seal

Heartland5 days ago

Delic Looks to Build a Sprawling ‘Psychedelic Ecosystem’

Heartland3 days ago

Never been a “flavored” CBD person but the hint of mint in this product is not bad.

Heartland3 days ago

My new ‘Up in Smoke’ 40th Anniversary Rolling Tray! 🌱🎱😎 Love it! High Quality and Much Larger than Anticipated!

Heartland4 days ago

Cannabis Antibiotics: Answer to Disease-Resistant Bacteria

Heartland2 days ago

Anyone had issues ordering from the US to the uk

Heartland3 days ago

Cannabis for Eating Disorders Like Anorexia

Heartland5 days ago

Cannabis use and measurement of cannabinoids in plasma and breast milk of breastfeeding mothers

Heartland4 days ago

19 in texas I know it is technically legal to possess hemp flower I’m wondering about the penalties of possession under 21

Heartland2 days ago

CBD oil causing issues with heart

Heartland5 days ago

A Documentary about CBD

Heartland5 days ago

Can I take CBD while already taking anti inflammatory medication? What are some recommendations for using CBD for arthritis/anxiety?

Heartland3 days ago

Update – bought some of this 33% Moonbarguy hash instead of the HempHash. Hope it’s better

Heartland2 days ago

Anyone heard of or have tried this brand? Location near Dallas Texas

Heartland2 days ago

Newbie questions regarding cbd & anxiety

Heartland3 days ago

How CBD changed a young boy’s life

Heartland5 days ago

trying CBD for the first time- any experience with this product/brand?

Heartland3 days ago

Minty taste when vaping CBD isolate?

Heartland5 days ago

Mixing Oil with CBD Isolate

Uncategorized2 days ago

USDA Final Rule on Hemp

Heartland3 days ago

Quitting Nicotine

Trending

A Cloud Nine Capital Entity Copyright © 2020 – All Rights Reserved Proudly Made in America