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Dramatic response to Laetrile and cannabidiol (CBD) oil in a patient with metastatic low grade serous ovarian carcinoma

•Complimentary alternative medicine use is common in women with gynecologic cancers.•Cannabinoid receptors are potential therapeutic targets in ovarian cancer.•Communication with patients is critical regarding use of alternative therapies.

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Case Reports

. 2019 May 17;29:10-12.

doi: 10.1016/j.gore.2019.05.004. eCollection 2019 Aug.

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Case Reports

Allison M Barrie et al. Gynecol Oncol Rep. .

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Abstract

•Complimentary alternative medicine use is common in women with gynecologic cancers.•Cannabinoid receptors are potential therapeutic targets in ovarian cancer.•Communication with patients is critical regarding use of alternative therapies.

Keywords: Cannabidol; Complimentary alternative medicine; Laetrile; Low grade ovarian cancer.

Figures

Fig. 1

Fig. 1

CT scan May 2017, illustrating a right adnexal mass measuring 5.8 cm × 5.0 cm.

Fig. 2

Fig. 2

Ca-125 trend on treatment.

Fig. 3

Fig. 3

CT scan November 2017, illustrating interval decrease in size of the right adnexal mass to 1.6 cm × 1.6 cm.

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References

    1. Farley J., Brady W.E., Vathipadiekal V., Lankes H.A., Coleman R., Morgan M.A., Mannel R., Yamada D., Mutch D., Rodgers W.H., Birrer M., Gershenson D.M. Vol. 14. 2013. Articles Selumetinib in Women with Recurrent Low-Grade Serous Carcinoma of the Ovary or Peritoneum: an Open-Label, Single-Arm, Phase 2 Study.Www.Thelancet.Com/Oncology PMC PubMed
    1. Gansler T., Kaw C., Crammer C., Smith T. A population-based study of prevalence of complementary methods use by cancer survivors: a report from the American Cancer Society’s studies of cancer survivors. Cancer. 2008;113:1048–1057. – PubMed
    1. Gershenson D.M., Bodurka D.C., Lu K.H., Nathan L.C., Milojevic L., Wong K.K., Malpica A., Sun C.C. Impact of age and primary disease site on outcome in women with low-grade serous carcinoma of the ovary or peritoneum: results of a large single-institution registry of a rare tumor. J. Clin. Oncol. 2015;33:2675–2682. – PMC PubMed
    1. Grisham R.N., Iyer G. Low-grade serous ovarian Cancer: current treatment paradigms and future directions. Curr. Treat. Options in Oncol. 2018;19 – PubMed
    1. Johnson S.B., Park H.S., Gross C.P., Yu J.B. Complementary medicine, refusal of conventional Cancer therapy, and survival among patients with curable cancers. JAMA Oncol. 2018;4:1375. – PMC PubMed

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