Connect with us

Heartland

Discrete opioid gene expression impairment in the human fetal brain associated with maternal marijuana use

Fetal development is a period sensitive to environmental influences such as maternal drug use. The most commonly used illicit drug by pregnant women is marijuana. The present study investigated the effects of in utero marijuana exposure on expression levels of opioid-related genes in the human fetal forebrain in light of the strong interaction between the cannabinoid and opioid systems. The study group consisted of 42 midgestation fetuses from saline-induced voluntary abortions. The opioid…

Republished by Plato

Published

on

Fetal development is a period sensitive to environmental influences such as maternal drug use. The most commonly used illicit drug by pregnant women is marijuana. The present study investigated the effects of in utero marijuana exposure on expression levels of opioid-related genes in the human fetal forebrain in light of the strong interaction between the cannabinoid and opioid systems. The study group consisted of 42 midgestation fetuses from saline-induced voluntary abortions. The opioid peptide precursors (preprodynorphin and preproenkephalin (PENK)) and receptor (mu, kappa and delta) mRNA expression were assessed in distinct brain regions. The effect of prenatal cannabis exposure was analyzed by multiple regression controlling for confounding variables (maternal alcohol and cigarette use, fetal age, sex, growth measure and post-mortem interval). Prenatal cannabis exposure was significantly associated with increased mu receptor expression in the amygdala, reduced kappa receptor mRNA in mediodorsal thalamic nucleus and reduced preproenkephalin expression in the caudal putamen. Prenatal alcohol exposure primarily influenced the kappa receptor mRNA with reduced levels in the amygdala, claustrum, putamen and insula cortex. No significant effect of prenatal nicotine exposure could be discerned in the present study group. These results indicate that maternal cannabis and alcohol exposure during pregnancy differentially impair opioid-related genes in distinct brain circuits that may have long-term effects on cognitive and emotional behaviors.

Source: https://pubmed.ncbi.nlm.nih.gov/16477274/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1z7zlNEMzQex5jriqkhCblNtckSEpT9xYlxxeymU_73UTETESY&fc=20200804213258&ff=20200812123047&v=2.11.5

Heartland

Republished by Plato

Published

on

Coinsmart. Beste Bitcoin-Börse in Europa
Source:

Continue Reading

Heartland

Republished by Plato

Published

on

Coinsmart. Beste Bitcoin-Börse in Europa
Source:

Continue Reading

Heartland

Republished by Plato

Published

on

Coinsmart. Beste Bitcoin-Börse in Europa
Source:

Continue Reading
Uncategorized4 days ago

Halo Collective Announces New Appointment to Board of Directors and Completes Securities Issuance to Independent Consultants, Related Parties, and Suppliers

Metal4 days ago

Registration open for IHEA annual meeting

Heartland2 days ago

Real Brands Inc. CEO Discusses Corporate Goals and Resolve in Audio Interview with …

Heartland4 days ago

Asia Pacific IoT command centre to be established in Adelaide

Heartland2 days ago

Harvard Study Finds Cannabis Effective for Chronic Pain

Heartland1 day ago

First time with WNC or any Indoor CBD in general.

Heartland4 days ago

does cbd help with dizziness?

Heartland1 day ago

Any sales for goin on ?

Heartland2 days ago

I just bought this brand that I have never seen before. Has anyone ever heard of it?

Heartland3 days ago

Are Delta-8 THC Syringes the Most Practical Way to Medicate?

Heartland21 hours ago

At Virtual Forum, Wisconsin Gov. Tony Evers Calls on Lawmakers to Legalize Cannabis

Heartland5 days ago

Heartland5 days ago

Heartland5 days ago

Heartland4 days ago

Heartland4 days ago

Heartland4 days ago

Heartland10 hours ago

The future of the cannabis industry and sports

Heartland4 days ago

Auckland CBD shop among newest locations of interest for Covid-positive border worker

Heartland4 days ago

Heartland4 days ago

Heartland3 days ago

Heartland2 days ago

Heartland4 days ago

Heartland4 days ago

Heartland4 days ago

Northeast Regulators Talk Cannabis, Real Estate, and Regional Collaboration

Heartland5 days ago

Do you have a favorite CBD product?

News5 days ago

Get Ready for Some Volatility

Heartland4 days ago

Are there usually deals on 4/20? Especially at WNC.

Heartland4 days ago

What’s the best flower in EU? (<0.2% THC)

Trending

A Cloud Nine Capital Entity Copyright © 2020 – All Rights Reserved Proudly Made in America