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Discrete opioid gene expression impairment in the human fetal brain associated with maternal marijuana use

Fetal development is a period sensitive to environmental influences such as maternal drug use. The most commonly used illicit drug by pregnant women is marijuana. The present study investigated the effects of in utero marijuana exposure on expression levels of opioid-related genes in the human fetal forebrain in light of the strong interaction between the cannabinoid and opioid systems. The study group consisted of 42 midgestation fetuses from saline-induced voluntary abortions. The opioid…

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Fetal development is a period sensitive to environmental influences such as maternal drug use. The most commonly used illicit drug by pregnant women is marijuana. The present study investigated the effects of in utero marijuana exposure on expression levels of opioid-related genes in the human fetal forebrain in light of the strong interaction between the cannabinoid and opioid systems. The study group consisted of 42 midgestation fetuses from saline-induced voluntary abortions. The opioid peptide precursors (preprodynorphin and preproenkephalin (PENK)) and receptor (mu, kappa and delta) mRNA expression were assessed in distinct brain regions. The effect of prenatal cannabis exposure was analyzed by multiple regression controlling for confounding variables (maternal alcohol and cigarette use, fetal age, sex, growth measure and post-mortem interval). Prenatal cannabis exposure was significantly associated with increased mu receptor expression in the amygdala, reduced kappa receptor mRNA in mediodorsal thalamic nucleus and reduced preproenkephalin expression in the caudal putamen. Prenatal alcohol exposure primarily influenced the kappa receptor mRNA with reduced levels in the amygdala, claustrum, putamen and insula cortex. No significant effect of prenatal nicotine exposure could be discerned in the present study group. These results indicate that maternal cannabis and alcohol exposure during pregnancy differentially impair opioid-related genes in distinct brain circuits that may have long-term effects on cognitive and emotional behaviors.

Source: https://pubmed.ncbi.nlm.nih.gov/16477274/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1z7zlNEMzQex5jriqkhCblNtckSEpT9xYlxxeymU_73UTETESY&fc=20200804213258&ff=20200812123047&v=2.11.5

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Looking for something to help with my…everything

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I have a laundry list of conditions, both physical and mental. I am looking at a few different types of CBD, namely vape juices and flowers. I am looking for strains that help with anxiety, depression, insomnia, PTSD, mood swings, and nerve and joint pain. I take medication for all of these things, but these conditions still plague my life. Are there any specific strains or flowers I should be looking at?

Source: https://www.reddit.com/r/CBD/comments/l4icle/looking_for_something_to_help_with_myeverything/

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Recipes for making CBD Flower into gummies?

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My wife uses the CBD flower and I was thinking about making her flower into gummies. A friend of her gave her 2 ounces of flower, but that’s way too much for her to use before it goes bad. I tried googling some stuff but it’s all pretty confusing and it was like factory production of CBD. Any info this group may have will be very helpful!

Source: https://www.reddit.com/r/CBD/comments/l4gnwh/recipes_for_making_cbd_flower_into_gummies/

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New T5 strain from Roots and Herb Farm

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Visit our community site for vetted suppliers at http://theCBD.place. It’s time that this subject was given more internet exposure. We are here to discuss topics related to medical marijuana and our experiences using CBD. Please do not assume that anyone here is a medical professional.

Source: https://www.reddit.com/r/CBD/comments/l4gjgf/new_t5_strain_from_roots_and_herb_farm/

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