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Depression, GABA, and Age Correlate with Plasma Levels of Inflammatory Markers

Immunomodulation is increasingly being recognised as a part of mental diseases. Here, we examined whether levels of immunological protein markers changed with depression, age, or the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). An analysis of plasma samples from patients with a major depressive episode and control blood donors (CBD) revealed the expression of 67 inflammatory markers. Thirteen of these markers displayed augmented levels in patients compared to CBD. Twenty-one…

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Immunomodulation is increasingly being recognised as a part of mental diseases. Here, we examined whether levels of immunological protein markers changed with depression, age, or the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). An analysis of plasma samples from patients with a major depressive episode and control blood donors (CBD) revealed the expression of 67 inflammatory markers. Thirteen of these markers displayed augmented levels in patients compared to CBD. Twenty-one markers correlated with the age of the patients, whereas 10 markers correlated with the age of CBD. Interestingly, CST5 and CDCP1 showed the strongest correlation with age in the patients and CBD, respectively. IL-18 was the only marker that correlated with the MADRS-S scores of the patients. Neuronal growth factors (NGFs) were significantly enhanced in plasma from the patients, as was the average plasma GABA concentration. GABA modulated the release of seven cytokines in anti-CD3-stimulated peripheral blood mononuclear cells (PBMCs) from the patients. The study reveals significant changes in the plasma composition of small molecules during depression and identifies potential peripheral biomarkers of the disease.

Keywords: GABAA receptor; inflammation; mental health.

Source: https://pubmed.ncbi.nlm.nih.gov/31817800/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1TQbL92JdzYTve0m3OsSoggMby2JyZDVBLRHiDMYZkT1hs6YNQ&fc=20200804223051&ff=20200814033422&v=2.11.5

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My Mom Is In A Lot Of Pain. So Much Nerve Damage They Had To Remove 3 Disks In Her Neck. Assistance On CBD And Med Interactions, Please!

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My mom is taking Januvia, Glipizide, Lantus Injections, and Trulicity Injections. I really think gummies with CBD:THC 100:1 would really help her. Unfortunately, I have heard that diabetes medications might interfere with CBD and vice versa. Does anyone have any experience with interactions with these medications? None of her prescriptions have the grapefruit warning on the labels.

Edited to make corrections.

Source: https://www.reddit.com/r/CBD/comments/l23ooi/my_mom_is_in_a_lot_of_pain_so_much_nerve_damage/

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MP Trae el Flow del Año 3000: Su Papel en Red Bull, Su Anhelo de FMS y su Tema con Kódigo

ElPlanteo.com entrevista al freestyler y músico MP, también conocido como “El Juvenil”. Nacido en 1999 su nombre viene, según dice, de que se ve muy joven en escena.

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MP Trae el Flow del Año 3000: Su Papel en Red Bull, Su Anhelo de FMS y su Tema con Kódigo | High Times





























Source: https://hightimes.com/espanol/mp-trae-el-flow-del-ano-3000-su-papel-en-red-bull-su-anhelo-de-fms-y-su-tema-con-kodigo/

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Bert Kreischer on Comedy Shows During COVID And Hanging Out With Snoop Dogg

Comedian Bert Kreisher is a “go big or go home” type of man.

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Bert Kreischer on Comedy Shows During COVID And Hanging Out With Snoop Dogg | High Times






























Source: https://hightimes.com/celebrities/bert-kreischer-comedy-shows-during-covid-hanging-out-with-snoop-dogg/

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