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Could the Combination of Two Non-Psychotropic Cannabinoids Counteract Neuroinflammation? Effectiveness of Cannabidiol Associated with Cannabigerol

Background and Objectives: Neuroinflammation is associated with many neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). In this study, we investigate the anti-inflammatory, anti-oxidant, and anti-apoptotic properties of two non-psychoactive phytocannabinoids, cannabigerol (CBG) and cannabidiol (CBD). Materials and Methods: The motoneuron-like cell line NSC-34 differentiated by serum deprivation and with the additional treatment of all-trans retinoic acid (RA) is a valid…

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Background and Objectives: Neuroinflammation is associated with many neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). In this study, we investigate the anti-inflammatory, anti-oxidant, and anti-apoptotic properties of two non-psychoactive phytocannabinoids, cannabigerol (CBG) and cannabidiol (CBD). Materials and Methods: The motoneuron-like cell line NSC-34 differentiated by serum deprivation and with the additional treatment of all-trans retinoic acid (RA) is a valid model to investigate molecular events linked to neurodegeneration in ALS. Results: Pre-treatment with CBG (at 2.5 and 5 µM doses) alone and in combination with CBD (at 2.5 and 5 µM doses) was able to reduce neuroinflammation induced by a culture medium of LPS-stimulated macrophages. In particular, the pre-treatment with CBD at a 5 µM dose decreased TNF-α levels and increased IL10 and IL-37 expression. CBG-CBD association at a 5 µM dose also reduced NF-kB nuclear factor activation with low degradation of the inhibitor of kappaB alpha (IkBα). CBG and CBD co-administered at a 5 µM dose decreased iNOS expression and increased Nrf2 levels. Furthermore, the pre-treatment with the association of two non-psychoactive cannabinoids downregulated Bax protein expression and upregulated Bcl-2 expression. Our data show the anti-inflammatory, anti-oxidant, and anti-apoptotic effects PPARγ-mediated. Conclusions: Our results provide preliminary support on the potential therapeutic application of a CBG-CBD combination for further preclinical studies.

Keywords: NSC-34 cells; amyotrophic lateral sclerosis (ALS); cannabidiol; cannabigerol; lipopolysaccharide (LPS); neuroinflammation.

Source: https://pubmed.ncbi.nlm.nih.gov/31752240/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1TQbL92JdzYTve0m3OsSoggMby2JyZDVBLRHiDMYZkT1hs6YNQ&fc=20200804223051&ff=20200815003443&v=2.11.5

Heartland

Scraped this blob of sticky stuff off the blades of our trimmer machine and put it in a pocket of my backpack about a month ago then forgot about it. Just remembered it.

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Visit our community site for vetted suppliers at http://theCBD.place. It’s time that this subject was given more internet exposure. We are here to discuss topics related to medical marijuana and our experiences using CBD. Please do not assume that anyone here is a medical professional.

Source: https://www.reddit.com/r/CBD/comments/jkrdav/scraped_this_blob_of_sticky_stuff_off_the_blades/

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Heartland

Why do smoke shops only sell shitty cbd carts?

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Primal nation wide has good ones. Anything in shops is either expensive as fuck or garbage so you buy the expensive stuff in the future… primal has Cbd you can make carts with super cheap right now but his carts are also like buy one get one 50 percent off I think. I think 30 for 2 gram carts

Source: https://www.reddit.com/r/CBD/comments/jkoody/why_do_smoke_shops_only_sell_shitty_cbd_carts/

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Heartland

We will compile a list for black friday

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We will compile a list for black friday of all the deals going on.

We already have some compiled, such as 40% off big sky bontanicals or theCBDistillery.

Please don’t make posts about black friday deals – but instead we will release our post a few days before and you can post the discounts there.

Remember – do not share links. It violates the rules.

Source: https://www.reddit.com/r/CBD/comments/jknp8z/we_will_compile_a_list_for_black_friday/

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