Connect with us

Heartland

Combination of cannabinoids, delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), mitigates experimental autoimmune encephalomyelitis (EAE) by altering the gut microbiome

Currently, a combination of marijuana cannabinoids including delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) is used as a drug to treat muscle spasticity in patients with Multiple Sclerosis (MS). Because these cannabinoids can also suppress inflammation, it is unclear whether such patients benefit from suppression of neuroinflammation and if so, what is the mechanism through which cannabinoids act. In the currently study, we used a murine model of MS, experimental autoimmune…

Republished by Plato

Published

on

Currently, a combination of marijuana cannabinoids including delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) is used as a drug to treat muscle spasticity in patients with Multiple Sclerosis (MS). Because these cannabinoids can also suppress inflammation, it is unclear whether such patients benefit from suppression of neuroinflammation and if so, what is the mechanism through which cannabinoids act. In the currently study, we used a murine model of MS, experimental autoimmune encephalomyelitis (EAE), to study the role of gut microbiota in the attenuation of clinical signs of paralysis and inflammation caused by cannabinoids. THC + CBD treatment attenuated EAE and caused significant decrease in inflammatory cytokines such as IL-17 and IFN-γ while promoting the induction of anti-inflammatory cytokines such as IL-10 and TGF-β. Use of 16S rRNA sequencing on bacterial DNA extracted from the gut revealed that EAE mice showed high abundance of mucin degrading bacterial species, such as Akkermansia muciniphila (A. muc), which was significantly reduced after THC + CBD treatment. Fecal Material Transfer (FMT) experiments confirmed that THC + CBD-mediated changes in the microbiome play a critical role in attenuating EAE. In silico computational metabolomics revealed that LPS biosynthesis, a key component in gram-negative bacteria such as A. muc, was found to be elevated in EAE mice which was confirmed by demonstrating higher levels of LPS in the brain, while treatment with THC + CBD reversed this trend. EAE mice treated with THC + CBD also had significantly higher levels of short chain fatty acids such as butyric, isovaleric, and valeric acids compared to naïve or disease controls. Collectively, our data suggest that cannabinoids may attenuate EAE and suppress neuroinflammation by preventing microbial dysbiosis seen during EAE and promoting healthy gut microbiota.

Keywords: Akkermansia muciniphila; CBD; EAE; Gut microbiome; LPS; Multiple sclerosis; SCFAs; THC.

Source: https://pubmed.ncbi.nlm.nih.gov/31356922/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1TQbL92JdzYTve0m3OsSoggMby2JyZDVBLRHiDMYZkT1hs6YNQ&fc=20200804223051&ff=20200815134947&v=2.11.5

Heartland

Republished by Plato

Published

on

Source:

Continue Reading

Heartland

Republished by Plato

Published

on

Source:

Continue Reading

Heartland

Republished by Plato

Published

on

Source:

Continue Reading
Heartland19 hours ago

CBD Vape Oil Market 2021: Global Trends, Business Overview, Challenges, Opportunities …

Heartland5 days ago

Heartland5 days ago

What are Acidic Cannabinoids, and How Do They Work?

Heartland4 days ago

Uncategorized4 days ago

What CBD Oil is Right For Me?

Heartland4 days ago

Heartland3 days ago

Heartland4 days ago

Registration opens for consumable hemp manufacturers and retailers

Heartland5 days ago

It really works

Manufacturing5 days ago

Shift 5% of Workforce Training Funds to Advance Entrepreneurship

Heartland5 days ago

It's all about the vibe

Heartland4 days ago

CBD Oil for Beginners

Heartland4 days ago

CBP Can't Block Parts Imports, Hemp Machinery Co. Says

Heartland3 days ago

8 of the best cannabis gummies to try right now

Heartland5 days ago

website for flower

Heartland5 days ago

Heartland4 days ago

Interactions between CBD and hormonal contraception

Metal4 days ago

Pakistani CRC and HDG producers raise prices on higher input costs

Heartland4 days ago

CBD Skincare Products Are Popping Up Everywhere — But Do They Actually Work?

Heartland3 days ago

Heartland3 days ago

Heartland5 days ago

Nebraska Ag Expo kicks off at Lancaster Event Center

Heartland5 days ago

Superior Vibes CBD Oil

Material4 days ago

IMC microstructure modification and mechanical reinforcement of Sn–Ag–Cu/Cu microelectronic joints through an advanced surface finish technique

Heartland4 days ago

Sunnyvale Labs CBD Gummies — Instant Pain Relief Hemp Gummies!

Heartland2 days ago

National Hemp Association Awards First Recipients of Social Equity Conscious Business (SECB …

News5 days ago

Feds Arrest Emma Coronel Aispuro, ‘El Chapo’ Guzmán’s Wife, On Drug Trafficking Charges

Heartland4 days ago

Material4 days ago

A new approach of predicting dynamic recrystallization using directly a flow stress model and its application to medium Mn steel

Heartland4 days ago

Hemp Is Creating an EcoRevolution

Trending

A Cloud Nine Capital Entity Copyright © 2020 – All Rights Reserved Proudly Made in America