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Clinical and biochemical heterogeneity of Parkinson’s disease

OBJECTIVE: To study correlations between oxidative stress (OS) and clinical changes in patients with neurodegenerative Parkinson’s and to identify clinical/biochemical subtypes of the disease.

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Objective: To study correlations between oxidative stress (OS) and clinical changes in patients with neurodegenerative Parkinson’s and to identify clinical/biochemical subtypes of the disease.

Material and methods: One hundred and nine people were studied, including 91 patients with neurodegenerative Parkinson’s (72 patients with Parkinson’s disease (PD); 10 with multiple system atrophy (MSA); 9 with corticobasal degeneration (CBD), average age 61.1±7.2 years), and 18 clinically healthy people (average age 55.1±9.2). OS indexes were detected for scoring of redox state in peripheral blood of patients with PD and healthy people (control group). Detection of biochemical indexes was performed in erythrocytes and mononuclear fraction and blood. The activity of glutathione reductase (GR), myeloperoxidase (MPO) and content of reduced glutathione (GSH) was estimated.

Results and conclusions: OS is a universal mechanism and is observed in many neurodegenerative diseases. However it is possible to identify quite typical changes of redox state with group selection and their correlations with definite subtypes and PD progress, it gives opportunity, in particular, to make the differential diagnosis with atypical Parkinsonism.

Цель исследования: Изучение связи показателей окислительного стресса и клинических изменений у пациентов с нейродегенеративным паркинсонизмом и выделение клинико-биохимических подтипов заболевания.

Материал и методы: В исследование включены 109 человек, из них 91 пациент с нейродегенеративным паркинсонизмом (72 пациента с болезнью Паркинсона (БП), 10 — с мультисистемной атрофией (МСА), 9 — с кортикобазальной дегенерацией; средний возраст — 61,1±7,2 года) и 18 клинически здоровых людей, средний возраст — 55,1±9,2 года. Для оценки редокс-статуса в периферической крови пациентов с БП и здоровых лиц определяли показатели окислительного стресса. Определение биохимических показателей проводили в эритроцитах и мононуклеарной фракции крови. Оценивалась активность глутатионредуктазы (GR) и миелопероксидазы (MPO), содержание восстановленного глутатиона.

Результаты и заключение: Окислительный стресс является универсальным механизмом и наблюдается при многих нейродегенеративных заболеваниях. Тем не менее возможно выявить достаточно характерные изменения редокс-баланса с выделением групп и их корреляций с определенными подтипами и течением БП, что дает возможность проводить дифференциальный диагноз с атипичным паркинсонизмом.

Keywords: Parkinson’s disease; heterogeneity; oxidative stress.

Source: https://pubmed.ncbi.nlm.nih.gov/33459545/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1zmroqAMnEquTZFTfdGx1V1gPEavo-Be3-FKTecJpOlB7LykCL&fc=20200804213506&ff=20210118151157&v=2.14.2

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CBD hash I bought gives off an extremely strange smell. Is this bad hash? More details in the comments!

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CBD hash I bought gives off an extremely strange smell. Is this bad hash? More details in the comments! submitted by /u/Threwaway1105
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100 Million Dollar Cannabis Bank Fraud, House Bill 1420, & Mexico’s Accredited Postgrad MMJ Program

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100 Million Dollar Cannabis Bank Fraud, House Bill 1420, & Mexico's Accredited Postgrad MMJ Program submitted by /u/Infinity_Broadcast
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