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CBD Oil for Dogs

Republished by Plato

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CBD is known to possibly help people with many ailments, from seizures to anxiety, but did you know it might also help dogs? If your dog has any issues listed below, CBD Oil is sure to help them live a healthier lifestyle. Today, I am going to speak through what CBD oil can do to help your dog.

Many veterinarians have begun to make findings as regards how the CBD drug can be utilized for the health care of dogs, and this has led to a few research studies on the topic. It must be noted that the surveys and researches of the use of CBD for dogs show great potential for the treatment of anxiety, phobia, pain and inflammation, and skin issues.

There are so many reasons why dogs suffer from anxiety, and this is not totally peculiar to any dog at all. As a matter of fact, there are common factors that could lead to the anxiety of a dog, and this includes a new environment, separation, loud noise, changes in its daily routine and a lot more.

In prior times people have made use of CBD for the treatment of some of their wellness issues, but this soon changed in recent times as people now count on CBD for the treatment of their pet needs. On the Google search list, it has been noted that thousands of people have begun looking for options for their dogs because they now understand the impact of CBD on the lives of living things.

WHATS THE BEST CBD OIL FOR YOUR PET?

OK, so you’ve decided to try a new regime when it comes to chill out and relax time. So now it’s time to decide what CBD products are best for your loved one. There are many products on the market, but due to inconsistency of some products – we have decided to give you the low down on some of the best selling CBD products for you dog which include;

Wellness Dog Treats (30g)

Hownd Hemp CBD Oil for Dogs

Hownd Hemp will keep your dog coming back for more, with 5 different flavors having it’s own blend of ingredients which can have benefit for your dog. Suitable for all ages, and made in the UK with locally sourced ingredients. Allow up to 1-5 treats per day, depending on the size of your dog. 

 Available from just £4.50.

Koi CBD Full Spectrum CBD Spray (60ml)

Koi CBD Spray for Dogs

Koi CBD introduced the full-spectrum CBD oil spray available to purchase in 60ml bottles. Full Spectrum CBD offers the full benefits of the Hemp plant with added nutrients and extra added natural terpenes and effects to use as a propreitary blend on your dog food or directly into your pets mouth. 

Available in a 60ml dropper bottle with 500mg CBD. With extra piece of mind knowing no chemical or pesticide residue, harvested in the USA and formulated by veterinarians. 

Available from just £44.99.

CBDFX Hemp Oil for Pets (30ml Up to 600mg CBD)

CBDFX Hemp Oil CBD For Dogs

CBDFX are a market leader when it comes to CBD oil products producing high quality products from premium grade ingredients. After releasing Hemp Oil for Pets, an official collection just for your pets, we needed to add this one to the collection. 

Available in 30ml dropper bottles and two strengths including (150mg for smaller breeds or up to 600mg for larger breeds).

Available from just £29.99.

BENEFITS OF CBD OIL FOR DOGS

The number of people seeking CBD for their dogs is steadily increasing with cannabidiol for pets looking to be the next big boom in sales. 

SEIZURES AND EPILEPSY

CBD oil has previously been shown to treat seizures. This also works for dogs who suffer from epilepsy and seizures, and many owners are trying it. Research show’s that CBD reduces the frequency of seizures over time, and, in some cases, get rid of the seizures altogether for some patients.

RELIEVING PAIN

Even dogs get arthritis, which is an inflammation of the joints causing aching, pains and other illnesses. CBD has the potential to relieve pain targeting the joints and giving the dog relief. It calms the chronic inflammation that prevents the dog from properly healing. 

IMPROVE APPETITE

It isn’t easy to know why your dog has lost its appetite, but most of the time, it is due to nausea. CBD may help reduce the digestion issue and provide pain relief. 

REDUCING ANXIETY

Anxiety is no fun, and, it’s the same with dogs. Many dogs suffer from anxiety and can be depressed and extremely anxious in certain situations, like when the owner leaves. This can result in destructive behaviours. CBD is a relaxing stimulant that might help to calm pets.

PREVENTING AND FIGHTING CANCER

Dogs can get cancer too, which can be spotted by symptoms of nausea, loss of appetite and chronic pain. CBD may help to comfort the pet during this time and helps to reduce side effects. Pet owners giving their dogs small daily doses of CBD may help prevent and kill cancer.

HELP WITH ALL DISEASES

Most diseases in dogs have the same types of symptoms, chronic pain, nausea, loss of appetite, and changes in behaviour. CBD has the potential to help humans and dogs by reducing anxiety, lowering stress, and aiding sleep, which together can reduce pain. 

WHAT ARE THE SIDE EFFECTS OF GIVING CBD OIL TO DOGS?

There is currently no scientific data on the side effects of giving CBD to dogs. But there are potential effects based on how it affects humans. 

Research has found that CBD can reduce saliva production. For dogs, this would result in increased thirst.

High doses of CBD have also been known to cause a temporary drop in blood pressure. Though the drop is small, it can create a feeling of lightheadedness.

The calming effect of CBD used to treat anxiety, can also cause slight drowsiness, especially when higher doses are used.

HOW TO GIVE DOGS CBD

There are many ways to give dogs CBD, but the best is tinctures so that you can give it to the dog a drop at a time.

Below is a guide of the three different dosage strengths you can use to help you dose your human CBD oil for your dog.

  • 0.05mg CBD x 0.5kg of body weight (low)
  • 0.125mg CBD x 0.5kg of body weight (mid)
  • 0.25mg CBD x 0.5kg of body weight (high)

Buy some CBD today to help your dog, and have a good day!

Source: https://vaporshopdirectcbd.com/blogs/news/cbd-oil-for-dogs

Heartland

Good cbd carts in LA?

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Live in LA so have access to all the dispensaries. Looking for a good cart recommendation as it seems to be the only method that has an effect for me before bed. Currently using a brand called “cannabis by design” 18:1 ratio and like it but I feel like there are better brands out there?

Thanks!

Source: https://www.reddit.com/r/CBD/comments/l0velw/good_cbd_carts_in_la/

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There may still be hope for the ‘not perfect’ USDA final rule on hemp

United States Department of Agriculture’s finalized hemp regulations, which were published on January 15, evoked a variety of responses f…

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United States Department of Agriculture’s finalized hemp regulations, which were published on January 15, evoked a variety of responses from those invested in the industry. In a previous blog post, we covered some of the changes between the final rule and the interim final rule (IFR) that have industry leaders celebrating. However, the final rule might be more of a mixed bag overall.

Although it includes some provisions that are expected to benefit the hemp industry, there are others that may leave industry leaders disappointed, including the requirements for harvest samples to come from hemp flowers, for total tetrahydrocannabinol (THC) testing, and for testing to occur in labs certified by the Drug Enforcement Administration (DEA).

“It does not seem to be clear that it is a definite improvement over the interim final rule but that it is not perfect. It does not go as far as some of the key things we requested,” Jonathan Miller told Marijuana Moment. Miller is the general counsel for the U.S. Hemp Roundtable.

Industry stakeholders reportedly encouraged the United States Department of Agriculture (USDA) to allow pre-harvest samples to come from a greater part of the plant or the whole plant instead of just the flower. The USDA did not include this change in its final rule. Instead, it claims that the flower is the most appropriate place to sample because THC is concentrated there.

Under the final rule, pre-harvest samples must still come from the cannabis flower. However, this requirement has been modified slightly. When the final rule goes into effect on March 22, the samples can be taken from about five to eight inches from the main stem, terminal bud, or central cola of the flowering top of the plant.

Another request made by industry stakeholders was for hemp crops to be tested for delta-9 THC instead of total THC content. Delta-9 THC is the main psychoactive component in cannabis — the component that can make people feel high. Total THC includes the possible conversion of tetrahydrocannabinolic acid (THCA) into THC.

Some reportedly believe that the total THC better represents the sample’s potential to get someone high because it accounts for the cannabinoids that could be activated with heat when the product is consumed through vaping, smoking , or cooking. However, THCA is not psychoactive, and not all products that may be made from hemp would result in THCA being converted to delta-9 THC.

Unfortunately, the USDA maintained that hemp must be tested for total THC content, and that the THC concentration for a legal hemp crop must be below 0.3%.

Perhaps the biggest disappointment to industry stakeholders is that the USDA’s final rule did not change the requirement for hemp testing to occur only at labs certified by the DEA.

“Registration is necessary because laboratories could possibly handle cannabis that tests above 0.3% THC on a dry weight basis, which is, by definition, marijuana and a Schedule 1 controlled substance,” the final rule states.

However, there are not enough qualifying labs available to efficiently handle the number of hemp tests needed in this growing industry, a fact that was acknowledged in the final rule.

The final rule adds, “[S]ince the IFR was published, numerous laboratories have applied for registration and DEA is working diligently to process these requests.”

In the meantime, the USDA is delaying the enforcement of this rule. It was first delayed in 2020, and the final rule extended this delay until December 2022.

Although the USDA’s final rule did include some positive steps, it also lacked several important changes that industry stakeholders were hoping to see.

“USDA seems to have declined to act upon many of the comments submitted, particularly concerning sampling uncertainty, DEA labs and Total THC among others,” Herrick Fox reportedly told Hemp Industry Daily. Fox is the owner of Meristem Farms and a former USDA rulemaker.

“Many are justifiably disappointed by the DEA’s continued (and in some ways expanded) role in the agricultural hemp program,” said Shawn Hauser in a press release. Hauser is a partner and chair of the Hemp and Cannabinoids Department at Vincente Sederberg LLP.

The USDA released its final rule in the last week of the Trump administration, but some industry leaders remain hopeful that the situation regarding hemp regulations may change under the Biden administration.

“We anticipate, as is customary of new administrations, that this rule will be one of many that will be frozen on the first day of the Biden administration,” Larry Farnsworth, a spokesperson for the National Industrial Hemp Council, reportedly told Marijuana Moment.

“We look forward to working through these issues with the incoming Biden administration,” he added.

Sources

[1] https://www.marijuanamoment.net/usda-releases-final-rule-for-hemp-two-years-after-crop-was-federally-legalized/

[2] https://www.federalregister.gov/documents/2021/01/19/2021-00967/establishment-of-a-domestic-hemp-production-program

[3] https://cannabusiness.law/what-is-total-thc-and-does-it-matter/

[4] https://www.ams.usda.gov/rules-regulations/hemp

[5] https://hempindustrydaily.com/hemp-industry-advocates-dish-reactions-on-usda-final-hemp-rules/

[6] https://vicentesederberg.com/press/usda-announces-final-rule-regulating-the-production-of-hemp-in-the-u.s/

Source: https://www.nothingbuthemp.net/post/there-may-still-be-hope-for-the-not-perfect-usda-final-rule-on-hemp

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Heartland

Alginate Affects Bioactivity of Chimeric Collagen-Binding LL37 Antimicrobial Peptides Adsorbed to Collagen-Alginate Wound Dressings

Chronic infected wounds cause more than 23,000 deaths annually. Antibiotics and antiseptics are conventionally used to treat infected wounds; however, they can be toxic to mammalian cells, and their use can contribute to antimicrobial resistance. Antimicrobial peptides (AMPs) have been utilized to address the limitations of antiseptics and antibiotics. In previous work, we modified the human AMP LL37 with collagen-binding domains from collagenase (cCBD) or fibronectin (fCBD) to facilitate…

Republished by Plato

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Chronic infected wounds cause more than 23,000 deaths annually. Antibiotics and antiseptics are conventionally used to treat infected wounds; however, they can be toxic to mammalian cells, and their use can contribute to antimicrobial resistance. Antimicrobial peptides (AMPs) have been utilized to address the limitations of antiseptics and antibiotics. In previous work, we modified the human AMP LL37 with collagen-binding domains from collagenase (cCBD) or fibronectin (fCBD) to facilitate peptide tethering and delivery from collagen-based wound dressings. We found that cCBD-LL37 and fCBD-LL37 were retained and active when bound to 100% collagen scaffolds. Collagen wound dressings are commonly made as composites with other materials, such as alginate. The goal of this study was to investigate how the presence of alginate affects the tethering, release, and antimicrobial activity of LL37 and CBD-LL37 peptides adsorbed to commercially available collagen-alginate wound dressings (FIBRACOL Plus-a 90% collagen and 10% alginate wound dressing). We found that over 85% of the LL37, cCBD-LL37, and fCBD-LL37 was retained on FIBRACOL Plus over a 14-day release study (90.3, 85.8, and 98.6%, respectively). Additionally, FIBRACOL Plus samples loaded with peptides were bactericidal toward Pseudomonas aeruginosa, even after 14 days in release buffer but demonstrated no antimicrobial activity against Escherichia coli, Staphylococcus aureus, and Staphylococcus epidermidis. The presence of alginate in solution induced conformational changes in the cCBD-LL37 and LL37 peptides, resulting in increased peptide helicity, and reduced antimicrobial activity against P. aeruginosa. Peptide-loaded FIBRACOL Plus scaffolds were not cytotoxic to human dermal fibroblasts. This study demonstrates that CBD-mediated LL37 tethering is a viable strategy to reduce LL37 toxicity, and how substrate composition plays a crucial role in modulating the antimicrobial activity of tethered AMPs.

Keywords: Pseudomonas aeruginosa; alginate; antimicrobial peptide; collagen scaffold; collagen-binding domain; peptide delivery.

Source: https://pubmed.ncbi.nlm.nih.gov/33463166/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1zmroqAMnEquTZFTfdGx1V1gPEavo-Be3-FKTecJpOlB7LykCL&fc=20200804213506&ff=20210119175353&v=2.14.2

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