Stress, anxiety, and depression are three ailments that often trigger one another in synergy. It often has negative effects on people’s jobs, social interactions, and even everyday chores. New studies show that CBD can be used in treatments for stress, anxiety, and depression
CBD oil against stress, anxiety, and depression.
Stress affects both the external as well as the interior. Temporary stress is usually not harmful, but longer, chronic stress can cause illness. How we perceive and manage stress can vary from person to person, but it is clear that stress affects us negatively.
It is common to experience stress for a shorter period of time, or due to certain events. It is a natural part of life and one of the body’s many different mechanisms. The problems begin to arise when stress takes over one’s everyday life. Symptoms from stress are not always obvious. We are all unique and the stress therefore arises and affects us in different ways. Some notice it mentally, for example in poor self-confidence or self-esteem, depression, resignation, aggression, low sexual drive, insomnia, and mood swings. Stress can also affect us in physical terms such as palpitations which are common, and even temporary stomach ulcers.
The importance of cortisol
Cortisol is a hormone that is formed in the adrenal glands. Cortisol is a hormone we cannot live without, but in large quantities, it can be dangerous to the body. This hormone is excreted when you are in a condition in which the body is forced to enter a defensive state. It can be due to healing after an operation, too little sleep, or a reaction to threats or physical hard work. Therefore, cortisol is formed when the body is under high pressure, either physically or mentally.
In small amounts and for short periods it is not harmful, but if you experience constant chronic stress or are under constant pressure, too much cortisol is produced and the levels can thus get out of balance. This can be harmful to the body, blood pressure, and immune system. The body becomes extra sensitive to infections and inflammation as a result.
Anxiety and depression
Anxiety comes in many different forms. Extreme nervousness, fear or insecurity can lead to anxiety
Depression often arises from stress and anxiety. Depression commonly leads to feelings of emptiness and resignation, a feeling of not being able to get out of bed in the morning and carry out daily tasks and duties. I can come from several reasons, such as experiencing a tragic experience or major changes in your life that can be difficult to process and deal with.
Research suggests that people with depression have reduced levels of serotonin and dopamine.
The signal substance known as dopamine is also called the “happiness substance” of the brain because the release of this substance gives a feeling of happiness and well-being. Serotonin is also a neurotransmitter that plays an important role in relation to mood, self-esteem, depression and many other things, and this is where the CBD comes into the picture.
Stress, anxiety, depression, and CBD
CBD has been shown to be a potentially good remedy for stress and anxiety because the CBD interacts with the endocannabinoid system. This system consists of receptors and neurotransmitters available to control most aspects of the body. When introducing the body to CBD, CBD enters and affects the endocannabinoid system. In the case of stress or anxiety, the cannabinoids interact with the receptors that are mainly located in the brain. Neurons in the central amygdala of the brain, where stress and anxiety are controlled, become less active.
In terms of stress, cortisol plays a very important role. CBD can suppress an increased cortisol level in the body. The body is usually good at regulating the cortisol level itself and maintaining a normal amount, but stress and anxiety have the ability to impact the amount of cortisol.
The influence of dopamine
As previously explained, people with depression have a reduced amount of certain signaling agents such as dopamine and serotonin. These signal elements play a major role in feelings of happiness, self-esteem, mood and mental balance. In depressed people, these receptors have simply become exhausted and emptied, which then leads to depression. Studies have shown that CBD can activate the serotonin receptors and help to boost self-esteem, mood and giving an anti-depressive effect.
There is still not a lot of research in this area, so CBD should only be seen as a healthy dietary supplement that clearly has the potential of helping people with depression, but not as a cure. Always seek a doctor if you have doubts about your mental condition or wish to treat severe depression with CBD, we can only guide you in relation to the research we keep up to date with.
CBD can be a good complement to treat a number of different mental disorders. However, it is important to remember that we do not want to give the impression that the CBD is a quick-fix or a miraculous cure. Basically, it is about solving the problems that give you stress. Once this is done, the CBD can help and create the very best conditions for better well-being.
The Role of Cannabinoids as Anticancer Agents in Pediatric Oncology
Cannabinoids are a group of chemicals that bind to receptors in the human body and, in turn, modulate the endocannabinoid system (ECS). They can be endogenously produced, synthetic, or derived from the plant Cannabis sativa L. Research over the past several decades has shown that the ECS is a cellular communication network essential to maintain multiple biological functions and the homeostasis of the body. Indeed, cannabinoids have been shown to influence a wide variety of biological effects,…
Cannabinoids are a group of chemicals that bind to receptors in the human body and, in turn, modulate the endocannabinoid system (ECS). They can be endogenously produced, synthetic, or derived from the plant Cannabis sativa L. Research over the past several decades has shown that the ECS is a cellular communication network essential to maintain multiple biological functions and the homeostasis of the body. Indeed, cannabinoids have been shown to influence a wide variety of biological effects, including memory, pain, reproduction, bone remodeling or immunity, to name a few. Unsurprisingly, given these broad physiological effects, alterations of the ECS have been found in different diseases, including cancer. In recent years, the medical use of cannabis has been approved in different countries for a variety of human conditions. However, the use of these compounds, specifically as anticancer agents, remains controversial. Studies have shown that cannabinoids do have anticancer activity in different tumor types such as breast cancer, melanoma, lymphoma and adult brain cancer. Specifically, phytocannabinoids Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) has been shown to induce apoptosis and inhibit proliferation of adult cancer cells, as well as modulate angiogenesis and metastasis. Despite increasing evidence that cannabinoids elicit antitumor effects in adult cancers, there is minimal data available on their effects in children or in pediatric cancers despite public and clinical demand for information. Here we describe a comprehensive and critical review of what is known about the effects of cannabinoids on pediatric cancers, highlight current gaps in knowledge and identify the critical issues that need addressing before considering these promising but controversial drugs for use in pediatric oncology.
Keywords: CBD; THC; cannabidiol; cannabinoid; childhood cancer; medical cannabis; pediatric oncology; Δ9-tetrahydrocannabinol.
Cannabis sativa L. as a Natural Drug Meeting the Criteria of a Multitarget Approach to Treatment
Cannabis sativa L. turned out to be a valuable source of chemical compounds of various structures, showing pharmacological activity. The most important groups of compounds include phytocannabinoids and terpenes. The pharmacological activity of Cannabis (in epilepsy, sclerosis multiplex (SM), vomiting and nausea, pain, appetite loss, inflammatory bowel diseases (IBDs), Parkinson’s disease, Tourette’s syndrome, schizophrenia, glaucoma, and coronavirus disease 2019 (COVID-19)), which has been…
Cannabis sativa L. turned out to be a valuable source of chemical compounds of various structures, showing pharmacological activity. The most important groups of compounds include phytocannabinoids and terpenes. The pharmacological activity of Cannabis (in epilepsy, sclerosis multiplex (SM), vomiting and nausea, pain, appetite loss, inflammatory bowel diseases (IBDs), Parkinson’s disease, Tourette’s syndrome, schizophrenia, glaucoma, and coronavirus disease 2019 (COVID-19)), which has been proven so far, results from the affinity of these compounds predominantly for the receptors of the endocannabinoid system (the cannabinoid receptor type 1 (CB1), type two (CB2), and the G protein-coupled receptor 55 (GPR55)) but, also, for peroxisome proliferator-activated receptor (PPAR), glycine receptors, serotonin receptors (5-HT), transient receptor potential channels (TRP), and GPR, opioid receptors. The synergism of action of phytochemicals present in Cannabis sp. raw material is also expressed in their increased bioavailability and penetration through the blood-brain barrier. This review provides an overview of phytochemistry and pharmacology of compounds present in Cannabis extracts in the context of the current knowledge about their synergistic actions and the implications of clinical use in the treatment of selected diseases.
Keywords: Cannabis; multitarget; phytocannabinoids (THC and CBD); receptors; terpenes.
Pervasive cropland in protected areas highlight trade-offs between conservation and food security
Global cropland expansion over the last century caused widespread habitat loss and degradation. Establishment of protected areas aims to counteract the loss of habitats and to slow species extinctions. However, many protected areas also include high levels of habitat disturbance and conversion for uses such as cropland. Understanding where and why this occurs may realign conservation priorities and inform protected area policy in light of competing priorities such as food security. Here, we use…
Global cropland expansion over the last century caused widespread habitat loss and degradation. Establishment of protected areas aims to counteract the loss of habitats and to slow species extinctions. However, many protected areas also include high levels of habitat disturbance and conversion for uses such as cropland. Understanding where and why this occurs may realign conservation priorities and inform protected area policy in light of competing priorities such as food security. Here, we use our global synthesis cropland dataset to quantify cropland in protected areas globally and assess their relationship to conservation aims and socio-environmental context. We estimate that cropland occupies 1.4 million km2 or 6% of global protected area. Cropland occurs across all protected area management types, with 22% occurring in strictly protected areas. Cropland inside protected areas is more prevalent in countries with higher population density, lower income inequality, and with higher agricultural suitability of protected lands. While this phenomenon is dominant in midnorthern latitudes, areas of cropland in protected areas of the tropics and subtropics may present greater trade-offs due to higher levels of both biodiversity and food insecurity. Although area-based targets are prominent in biodiversity goal-setting, our results show that they can mask persistent anthropogenic land uses detrimental to native ecosystem conservation. To ensure the long-term efficacy of protected areas, post-2020 goal setting must link aims for biodiversity and human health and improve monitoring of conservation outcomes in cropland-impacted protected areas.
Keywords: CBD; area-based targets; conservation; food security; protected areas.
Conflict of interest statement
The authors declare no competing interest.
- Klein Goldewijk K., Beusen A., Doelman J., Stehfest E.. New anthropogenic land use estimates for the holocene: HYDE 3.2. Earth Syst. Sci. Data. 2017;9:927–953.
- Barrett C. B.. Measuring food insecurity. Science. 2010;327:825–828.
- Fogel R. W.. The Escape from Hunger and Premature Death, 1700-2100: Europe, America, and the Third World. 2004.
- Crist E., Mora C., Engelman R.. The interaction of human population, food production, and biodiversity protection. Science. 2017;356:260–264.
- Pimm S. L., Vijay V.. Population, Agriculture, and Biodiversity: Problems and Prospects. 2020;365.
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