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Cannabisin F from Hemp (Cannabis sativa) Seed Suppresses Lipopolysaccharide-Induced Inflammatory Responses in BV2 Microglia as SIRT1 Modulator

Hemp seed (Fructus cannabis) is rich in lignanamides, and initial biological screening tests showed their potential anti-inflammatory and anti-oxidative capacity. This study investigated the possible effects and underlying mechanism of cannabisin F, a hempseed lignanamide, against inflammatory response and oxidative stress in lipopolysaccharide (LPS)-stimulated BV2 microglia cells. Cannabisin F suppressed the production and the mRNA levels of pro-inflammatory mediators such as interleukin 6…

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Hemp seed (Fructus cannabis) is rich in lignanamides, and initial biological screening tests showed their potential anti-inflammatory and anti-oxidative capacity. This study investigated the possible effects and underlying mechanism of cannabisin F, a hempseed lignanamide, against inflammatory response and oxidative stress in lipopolysaccharide (LPS)-stimulated BV2 microglia cells. Cannabisin F suppressed the production and the mRNA levels of pro-inflammatory mediators such as interleukin 6 (IL-6) and tumor necrosis factor α (TNF-α) in a concentration-dependent manner in LPS-stimulated BV2 microglia cell. Furthermore, cannabisin F enhanced SIRT1 expression and blocked LPS-induced NF-κB (Nuclear factor kappa B) signaling pathway activation by inhibiting phosphorylation of IκBα (Inhibit proteins of nuclear factor kappaB) and NF-κB p65. And the SIRT1 inhibitor EX527 significantly inhibited the effect of cannabisin F on pro-inflammatory cytokines production, suggesting that the anti-inflammatory effects of cannabisin F are SIRT1-dependent. In addition, cannabisin F reduced the production of cellular reactive oxygen species (ROS) and promoted the expression of Nrf2 (Nuclear factor erythroid-2 related factor 2) and HO-1 (Heme Oxygenase-1), suggesting that the anti-oxidative effects of cannabisin F are related to Nrf2 signaling pathway. Collectively, these results suggest that the neuro-protection effect of cannabisin F against LPS-induced inflammatory response and oxidative stress in BV2 microglia cells involves the SIRT1/NF-κB and Nrf2 pathway.

Keywords: SIRT1; anti-oxidative; cannabisin F; hemp seed; neuro-inflammatory.

Source: https://pubmed.ncbi.nlm.nih.gov/30691004/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1lg0RU4SkRVNqPFA7e6OZattw-Uzcw0dBEajJBQqmhHlNZ8MdX&fc=20200804212534&ff=20200813215111&v=2.11.5

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What is one of the strongest CBD in vaping form?

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Visit our community site for vetted suppliers at http://theCBD.place. It’s time that this subject was given more internet exposure. We are here to discuss topics related to medical marijuana and our experiences using CBD. Please do not assume that anyone here is a medical professional.

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Source: https://www.reddit.com/r/CBD/comments/m0zvtg/what_is_one_of_the_strongest_cbd_in_vaping_form/

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Anzac Day march increased to 5000 in Sydney's CBD

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Any veteran who wishes to participate in the Sydney CBD march will be required to register via the RSL NSW website.

In previous years, veterans and their descendants have not been required to register to march, with more than 12,000 taking to Sydney’s streets in 2019.

Earlier on Tuesday, Mr Morrison said he would like to see Anzac Day celebrations “return to normal as much as we possibly can”.

“I respect ultimately these are calls that have got to be made by state governments, but I want Anzac Day on,” he told reporters in Sydney.

“If people can party, and if people can protest, then we can remember as a nation and honour our veterans on Anzac Day. And I would like to see that done as fully and as safely as possible.”

In 2020, Anzac Day marches across Australia were cancelled as the nation entered strict coronavirus restrictions. In lieu of the march, “Light Up the Dawn” driveway services were held in neighbourhoods across the country.

Tuesday marked NSW’s 51st consecutive day of no locally acquired coronavirus cases.

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Source: https://www.google.com/url?rct=j&sa=t&url=https://www.smh.com.au/national/nsw/anzac-day-march-increased-to-5000-in-sydney-s-cbd-20210309-p5792r.html&ct=ga&cd=CAIyGjQ2MzM1ZTBkNWQyZmIyYzc6Y29tOmVuOlVT&usg=AFQjCNGJKXeFEPybOePsWcm_wHfdMbTZww

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Anzac Day march increased to 5000 in Sydney's CBD

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The Anzac Day march in Sydney's CBD will be capped at 5000 after RSL NSW reached an agreement with the NSW government and police to … Checkout PrimeXBT
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