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Cannabis Compounds May Help Reduce Lung Inflammation in COVID-19

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Key Takeaways

  • New research shows that certain cannabis compounds may decrease inflamed lung cells.
  • This research could have implications in the treatment of coronavirus patients because lung inflammation is one of the most debilitating and deadly complications in the later stage of the disease.
  • Innovative methods have been developed to test the efficacy of the compounds. 
  • Clinical trials have not yet been conducted and caution is needed going forward, because while some cannabis compounds have been found to decrease lung inflammation, others can increase it.

Cannabis compounds could be helpful in fighting lung cell inflammation in patients with COVID-19, according to a paper published in Scientific Reports in January.

The paper looks at how cannabis could potentially be used to treat the inflammation related to the COVID-19 virus (SARS-CoV-2). The virus stimulates an acute inflammation in the lungs as well as in other body organs, known as a “cytokine storm.” 

Cytokine storms take place when the body produces too many immune cells and compounds that activate them, called cytokines. The result can be lung damage, respiratory distress syndrome, organ failure and other severe medical problems. For some COVID-19 patients, the immune system response to COVID-19 is to produce these cytokine storms. 

Lung inflammation is one of the leading causes of death from the global pandemic, which has infected more than 100 million people around the world and taken over 2.3 million lives in a little over a year.

Study author Hinanit Koltai, PhD, a researcher at the Agricultural Research Organization (ARO) at the Volcani Center in Israel, tells Verywell her team has identified a CBD rich fraction (FCBD) from the extract of a cannabis strain that seems to be able modify immune system activity in lung cells and macrophage cells, which are responsible for releasing cytokines. In turn, this FCBD can reduce inflammation.

In addition to CBD, cannabis compounds CBG and THCV may have clinical value in reducing cytokine secretion in lung epithelial cells.

“On the one hand, we know that cannabis works for the reduction of pain for different medical conditions—for the alleviation of symptoms of Crohn’s disease and colitis, for example,” Koltai says. Although her team has not yet worked with the COVID-19 virus in their research, they have been able to induce COVID-19-like inflammation into cells, so these results could have implications in treating the disease.

Nanotechnology Delivers Cannabis Compounds to Cells

Study co-author Guy Mechrez, PhD, a chemist at the Institute for Postharvest and Food Science at ARO, says that he and his research group, who are working with material science and nanotechnology, saw a unique opportunity to collaborate in an innovative way in the cannabis compound research. 

Using nanoparticles, “we were able to create an advanced delivery system that allowed us to deliver cannabis-based active material [into cells],” he tells Verywell. “We worked on the development of particles to allow Hinanit’s group to monitor phagocytosis [intake of particles] by cells.”

Koltai and her team have registered a patent to protect specific cannabis compositions that counteract lung cell inflammation.

The patent is based on the exclusive formulation of active ingredients that have been selectively extracted from cannabis due to their high anti-inflammatory activity. It is important to note, she says, that certain compositions of compounds from the plant have also been found to lead to a significant reduction in the expression of the ACE2 gene, a protein in lung cells that acts as receptor through which the coronavirus enters cells.

But she found that while cannabis can decrease inflammation, it can also have the opposite effect and increase inflammation if the correct compounds and amounts are not used.

“Although more studies are needed of cannabis treatment in COVID-19 patients, there needs to be caution in proposing cannabis treatment for these patients, as is presently being suggested in the media,” she says. “Using the full-spectrum cannabis extract has led to an increase, not a decrease, in the properties of inflammation, which suggests that caution should be exercised in using cannabis for COVID-19 patients, and the active ingredients that reduce inflammation properties should be selected from cannabis.”

Koltai said her research group is hoping to move into clinical trials within a year.

“All efforts must be made to fight this new viral disease, and especially the acute inflammation that arises during the disease and may cause fatality,” she says.

What This Means For You

It’s still too early to know exactly how cannabis compounds would be administered to participants in clinical trials, but researchers are hopeful these compounds may be effective at stopping dangerous inflammation.

Source: https://www.google.com/url?rct=j&sa=t&url=https://www.verywellhealth.com/cannabis-compounds-reduce-lung-inflammation-covid-5112554&ct=ga&cd=CAIyGmRjNmI1OTk1NmZmODE5ZmQ6Y29tOmVuOlVT&usg=AFQjCNEbAD3iR34VBDyji79Dax45Z8wYFw

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Ask the Dentist: Could CBD help tackle not just plaque but deadly diseases?

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OVER Easter an insect took a liking to my leg and bit it. I thought nothing of it until the area started to swell and hurt a week later. To quell my runaway thoughts of spreading infection, cellulitis and death I decided to speak to a doctor, who prescribed some antibiotics. These are the first I have taken in 20 years and they worked a treat; the leg has been saved and equilibrium restored.

It got me thinking about how lucky we are to be able to stop infections from spreading and causing complications. Dentists prescribe about 10 per cent of all antibiotics given out – that’s a humongous three million scripts for dental infections written each year in the UK alone.

Antibiotics have been around for thousands of years but not in the modern fashion; the Egyptians squished mouldy bread on to their infected wounds to treat them. We needed to wait until 1909, when the German doctor Paul Ehrlich discovered that the chemical arsphenamine was effective when treating syphilis, before the first antibiotic was given to eternally grateful patients.

As with all good things, the success of antibiotics has a sting in its tail, that is the emergence of stubborn antibiotic-resistant infections. The rise of antibiotic resistance causes untold damage and death so researchers have logically been on the lookout for alternatives to antibiotics that can tame these difficult infections.

The University of Queensland and Botanix Pharmaceuticals Limited have teamed up and made a breakthrough discovery about cannabidiol, CBD. CBD is one of the active ingredients of cannabis (marijuana) – and it’s always stressed that it doesn’t cause a high as if that were a positive, which I will deliberate over while drinking my Bacardi and lemonade…

I digress. The researchers have shown for the first time that CBD can kill the bacteria responsible for gonorrhoea, meningitis and legionnaires disease. This is to be used to provide a new type of antimicrobial, the first in 60 years, that can be used to treat antibiotic-resistant bacteria.

The scientists also showed that CBD was useful in breaking down plaque bacteria on teeth which may see it being added to mainstream toothpastes in the future.

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Source: https://www.google.com/url?rct=j&sa=t&url=https://www.irishnews.com/lifestyle/2021/04/15/news/ask-the-dentist-could-cbd-help-tackle-not-just-plaque-but-deadly-diseases–2285321/&ct=ga&cd=CAIyGjQ2MzM1ZTBkNWQyZmIyYzc6Y29tOmVuOlVT&usg=AFQjCNEQzwDuXxKnsgi58sUhcZqFvFmZuQ

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Any sales for goin on ?

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Some of the rules have changed and we are trying to limit discussion of sourcing on the subreddit. I know its important when it comes to CBD, so we set up a community resource for you to use with everything related to CBD, including the important stuff. You can use it for the vetted list and information. The website is http://theCBD.place, Enjoy! This is a bot, if this is off topic please ignore!

I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.

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Source: https://www.reddit.com/r/CBD/comments/mr30ld/any_sales_for_goin_on/

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Can CBD help relieve PMS symptoms?

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However, for those who don't want to be pumping their bodies with chemicals on a monthly basis, there is a more natural alternative: CBD oil. Invest w Mintos
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