Heartland
Cannabinoids for the treatment of mental disorders and symptoms of mental disorders: a systematic review and meta-analysis
BACKGROUND: Medicinal cannabinoids, including medicinal cannabis and pharmaceutical cannabinoids and their synthetic derivatives, such as tetrahydrocannabinol (THC) and cannabidiol (CBD), have been suggested to have a therapeutic role in certain mental disorders. We analysed the available evidence to ascertain the effectiveness and safety of all types of medicinal cannabinoids in treating symptoms of various mental disorders.

Background: Medicinal cannabinoids, including medicinal cannabis and pharmaceutical cannabinoids and their synthetic derivatives, such as tetrahydrocannabinol (THC) and cannabidiol (CBD), have been suggested to have a therapeutic role in certain mental disorders. We analysed the available evidence to ascertain the effectiveness and safety of all types of medicinal cannabinoids in treating symptoms of various mental disorders.
Methods: For this systematic review and meta-analysis we searched MEDLINE, Embase, PsycINFO, the Cochrane Central Register of Controlled Clinical Trials, and the Cochrane Database of Systematic Reviews for studies published between Jan 1, 1980, and April 30, 2018. We also searched for unpublished or ongoing studies on ClinicalTrials.gov, the EU Clinical Trials Register, and the Australian and New Zealand Clinical Trials Registry. We considered all studies examining any type and formulation of a medicinal cannabinoid in adults (≥18 years) for treating depression, anxiety, attention-deficit hyperactivity disorder (ADHD), Tourette syndrome, post-traumatic stress disorder, or psychosis, either as the primary condition or secondary to other medical conditions. We placed no restrictions on language, publication status, or study type (ie, both experimental and observational study designs were included). Primary outcomes were remission from and changes in symptoms of these mental disorders. The safety of medicinal cannabinoids for these mental disorders was also examined. Evidence from randomised controlled trials was synthesised as odds ratios (ORs) for disorder remission, adverse events, and withdrawals and as standardised mean differences (SMDs) for change in symptoms, via random-effects meta-analyses. The quality of the evidence was assessed with the Cochrane risk of bias tool and Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach. This study is registered with PROSPERO (CRD42017059372, CRD42017059373, CRD42017059376, CRD42017064996, and CRD42018102977).
Findings: 83 eligible studies (40 randomised controlled trials, n=3067) were included: 42 for depression (23 randomised controlled trials; n=2551), 31 for anxiety (17 randomised controlled trials; n=605), eight for Tourette syndrome (two randomised controlled trials; n=36), three for ADHD (one randomised controlled trial; n=30), 12 for post-traumatic stress disorder (one randomised controlled trial; n=10), and 11 for psychosis (six randomised controlled trials; n=281). Pharmaceutical THC (with or without CBD) improved anxiety symptoms among individuals with other medical conditions (primarily chronic non-cancer pain and multiple sclerosis; SMD -0·25 [95% CI -0·49 to -0·01]; seven studies; n=252), although the evidence GRADE was very low. Pharmaceutical THC (with or without CBD) worsened negative symptoms of psychosis in a single study (SMD 0·36 [95% CI 0·10 to 0·62]; n=24). Pharmaceutical THC (with or without CBD) did not significantly affect any other primary outcomes for the mental disorders examined but did increase the number of people who had adverse events (OR 1·99 [95% CI 1·20 to 3·29]; ten studies; n=1495) and withdrawals due to adverse events (2·78 [1·59 to 4·86]; 11 studies; n=1621) compared with placebo across all mental disorders examined. Few randomised controlled trials examined the role of pharmaceutical CBD or medicinal cannabis.
Interpretation: There is scarce evidence to suggest that cannabinoids improve depressive disorders and symptoms, anxiety disorders, attention-deficit hyperactivity disorder, Tourette syndrome, post-traumatic stress disorder, or psychosis. There is very low quality evidence that pharmaceutical THC (with or without CBD) leads to a small improvement in symptoms of anxiety among individuals with other medical conditions. There remains insufficient evidence to provide guidance on the use of cannabinoids for treating mental disorders within a regulatory framework. Further high-quality studies directly examining the effect of cannabinoids on treating mental disorders are needed.
Funding: Therapeutic Goods Administration, Australia; Commonwealth Department of Health, Australia; Australian National Health and Medical Research Council; and US National Institutes of Health.
Heartland
Can cbd help prevent hearing loss due to noise?
Visit our community site for vetted suppliers at http://theCBD.place. It’s time that this subject was given more internet exposure. We are here to discuss topics related to medical marijuana and our experiences using CBD. Please do not assume that anyone here is a medical professional.
Source: https://www.reddit.com/r/CBD/comments/l5b0ik/can_cbd_help_prevent_hearing_loss_due_to_noise/
Heartland
Europe – Where to incorporate CBD affiliate company
I’m looking for advice. I have been working on CBD affiliate sites for the last few months, the sites are starting to have a decent amount of traffic and I need to incorporate a company.
The question is; where should I incorporate it? I’m not looking for massive tax breaks, but rather a country where the banking isn’t a massive headache and a place where I don’t have to be personally present.
Heartland
Plant Power: Everyday Plants That Activate the Endocannabinoid System
When people hear about cannabinoids, they automatically think of cannabis (which makes sense, given the name). What most have yet to realize is that many other plants make cannabinoids too – a lot of everyday flowers, vegetables, and spices that you probably wouldn’t expect. This train of thought was not exclusive to consumers though; until […]
The post Plant Power: Everyday Plants That Activate the Endocannabinoid System appeared first on CBD Testers.

When people hear about cannabinoids, they automatically think of cannabis (which makes sense, given the name). What most have yet to realize is that many other plants make cannabinoids too – a lot of everyday flowers, vegetables, and spices that you probably wouldn’t expect.
This train of thought was not exclusive to consumers though; until recently, even scientists had only been able to identify cannabinoids in the cannabis plant. But current studies have found these compounds in a handful of common, day-to-day plants, including clove, black pepper, cocoa, echinacea, broccoli, ginseng, hops, and even carrots.
But no matter how much of these plants you consume, they won’t feel any type of psychedelic effects. This is because they don’t have the cannabinoids we’re all familiar with, like tetrahydrocannabinol (THC), cannabidiol (CBD), or cannabigerol (CBN). Rather, they have their own compounds that directly engage our Endocannabinoid Systems (ECS).
The ECS is itself only recently discovered, and understanding how different phytocannabinoids interact with this network of neurotransmitters in our bodies can lead to important medical innovations in the future. Ones that are natural, safer for patients, and more focused on plant-based healthcare.
To learn more about cannabis, and for exclusive deals on flowers and other products, subscribe to The CBD Flowers Weekly Newsletter
Pain-relieving drugs made from plants
Chronic pain affects at least 10 percent of the global population, which is approximately 60 million people. However, experts estimate that figure to be closer to 20-25 percent on some countries and regions. Finding a solution that doesn’t put patients at risk for addiction and addition problems, is paramount.
As we humans have done since the dawn of time, we continue looking to the plant world for ways to improve our health and wellbeing. Cannabinoids might be the trendiest at the moment, but they’re certainly not the only plant-based compound that’s been utilized to help fight pain.
Opiates
Opiates get a bad rap because of their high rate for addiction and abuse, but they do have an important place in the world of medicine. Very intense pain, post-surgical or from a broken bone for example, typically won’t respond to cannabinoids. Something stronger like morphine, codeine, and other opiate drugs are sometimes necessary. They have many added ingredients these days, but believe-it-or-not, these medicates have a natural element to them. Opiates are made from opium, which comes from the poppy plant. Just like cannabinoids, these pharmaceutical drugs interact with opiate receptors in the human brain, which is why they can be incredibly effective when used responsibly.
Aspirin
Dating back to ancient Egypt, tea made from the willow tree was used to manage pain and reduce fever. Fast forward a few centuries and scientists are looking at the willow tree yet again, this time isolating the active compound used in that ancient tea – salicylic acid – and used it to formulate numerous medications used to treat pain and inflammation; most notably, aspirin. Salicylic acid is also a very common active ingredient in acne medication.
Anesthetics
Common anesthetics like lidocaine, used routinely by dentists to numb the mouth before initializing treatment, are also distantly related to wild plant – Coca. The leaves of the coca plant were used in the ancient Incan Empire in South America to treat many different levels of pain, from headaches to fractures. Eventually, the coca plant gave way to the drug cocaine, which is an illegal drug of abuse but also a very effective anesthetic.
Plant cannabinoids and the endocannabinoid system
Cannabis has been used medicinally for centuries, but it wasn’t until recently that science started to catch up with what our ancestors have been telling us. Ancient texts from China, Egypt, Tibet, and many other parts of the world hail cannabis as a natural remedy for numerous ailments including pain, inflammation, nausea, anxiety, epilepsy, and even sexual dysfunction. But how can one plant serve so many different functions in the human body? It all boils down to a network of receptors and neurotransmitters known as the Endocannabinoid System (ECS).
Unfortunately, the federally illegal status of cannabis and its use as a recreational drug has been a major hinderance on the ability of researchers to study the full capabilities of this plant. Until recently, most of the information we had came from scientists in Israel, where they had less restrictions when it came to using the plant compounds medicinally.
The Endocannabinoid System (ECS) is involved in multiple physiological processes including appetite regulation, pain threshold, sleep/wake cycles, memory, and mood. It plays a major role in allowing our bodies to achieve homeostasis, or internal balance. The discovery of the ECS shed new light on how and why plant-based cannabinoids, or phytocannabinoids, affect humans in the way they do. In cannabis alone, over 80 phytocannabinoids have been indexed and these compounds exist in many, many plants we consume regularly.
Other plants that engage the ECS
Like cannabis, many other plants have compounds that engage the endocannabinoid system, and with growing attention on this newly-discovered system, the more sources of phytocannabinoids we have the better. While these other plants don’t have cannabinoids as we know them, many of them contains Alkylamides, compounds that are structurally similar to endocannabinoids, and terpenes, that give plants their unique aromas – both of which effectively activate the ECS.
Plants of interest include (but not limited to):
- Black pepper
- Hops
- Helichrysum
- Oregano
- Cinnamon
- Carrots
- Basil
- Cloves
- Lavender
- Rosemary
- Cocoa
- Echinacea
- Black truffles
- Electric daisies
- Liverwort
- Kava
More about plant terpenes
Worth an additional mention since they often work synergistically with cannabinoids, in addition to activating the endocannabinoid system indirectly. Terpenes are a very large and diverse class of organic compounds that are produced by a wide variety of plants, including the ones listed above. In cannabis, they are secreted by the same glands that produce some of the more dominant cannabinoids including THC and CBD. Their role and effects are quite different, however.
Terpenes are aromatic plant oils that, when combined with other plant compounds, create a never-ending palate of scents and flavors. In nature, terps serve as a defense mechanism by deterring herbivores and by attracting predators and parasites that attack herbivores.
Chemically, terpenes are hydrocarbons, and they differ from terpenoids, which typically have added functional groups such as oxygen. The words “terpenes” and “terpenoids” are often used interchangeably but this is incorrect. Terpenes are also the major component of rosin, which a sap/waxy-like substance that is produced when cannabis buds are placed under high heat and pressure. Climate, weather, age and maturation, fertilizers, soil type, and light cycles can have an impact on the development of terpenes.
As far as cannabis goes, terpenes are the key to differentiating the effects and flavor of a strain. Some terpenes are relaxing, like those found in lavender, while others are energizing, like citrus. Some smell fruity, some are piney, others are musky, or even floral. There really is no limit to the variation. So far, over 100 different terpenes have been discovered in cannabis plants alone, and each strain typically has its own unique blend and composition of terps.
Terpenes have long been known to hold great therapeutic value, and some of the more common ones have been studied more extensively, considering they’re found in many different types of legal plants. More research is needed to determine the extent of their medicinal effects when combined with other cannabis plant compounds.
Conclusion
No matter how many veggies you munch on, or how many spices you add to your dish, you won’t get high from it like you would with actual cannabis. Our everyday plants don’t have THC, CBD, or any of the other major cannabinoids, but they have their own structurally similar compounds that engage with our Endocannabinoid Systems and can offer us natural, medicinal possibilities well beyond what science ever believed would be possible.
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RESOURCES:
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Source: https://cbdtesters.co/2021/01/26/plants-cannabinoids-endocannabinoid-system/
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