Heartland

Cannabinoids concentration variability in cannabis olive oil galenic preparations

CONCLUSIONS: Our results highlighted a wide variability in THC and CBD concentrations that justify the need for titration and opens further questions about other pharmaceutical preparations without regulatory indication for this procedure.

Published

3 years ago

October 24, 2017

Republished by Plato

Objectives: Knowledge of the exact concentration of active compounds in galenic preparations is crucial to be able to ensure their quality and to properly administer the prescribed dose. Currently, the need for titration of extracts is still debated. Considering this, together with the absence of a standard preparation method, the aim of this study was to evaluate cannabinoids concentrations variability in galenic olive oil extracts, to evaluate the interlot and interlaboratory variability in the extraction yield and in the preparation composition.

Methods: Two hundred and one extracts (123 (61.2%) from Bedrocan^® , 54 (26.9%) from Bediol^® , 11 (5.5%) from Bedrolite^® , and 13 (6.5%) from mixed preparations) were analysed by liquid chromatography coupled with tandem mass spectrometry, quantifying cannabinoids (THC, CBD, THCA, CBDA and CBN) concentrations.

Key findings: The RSD% of THC and CBD concentrations resulted higher than 50%. Specifically for Bedrocan^® , Bediol^® , Bedrolite^® (5 g/50 ml), these were THC 82%, THC 53% and CBD 91%, THC 58% and CBD 59%, respectively. The median extraction yields were greater than 75% for all preparations.

Conclusions: Our results highlighted a wide variability in THC and CBD concentrations that justify the need for titration and opens further questions about other pharmaceutical preparations without regulatory indication for this procedure.

Keywords: Bediol®; Bedrocan®; Bedrolite®; LC-MS; cannabis; cannabis olive oil.

Source: https://pubmed.ncbi.nlm.nih.gov/29057480/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1TUbR4JfRTv1rbahLd1HaiF0w5ryO5ocWB3_xk3Prq78L0AEhI&fc=20200804222312&ff=20200817013501&v=2.11.5

Related Topics:cannabis cbd extraction heartland method quality Regulatory thc

Up Next

The crop-residue of fiber hemp cv. Futura 75: from a waste product to a source of botanical insecticides

Don't Miss

Bio-affinity mediated immobilization of lipase onto magnetic cellulose nanospheres for high yield biodiesel in one time addition of methanol

Heartland

My experience with CBD

Published

1 hour ago

October 31, 2020

Republished by Plato

I will not spend an hour summarizing my mental health. I will just say that for years I have been plagued by depression, anxiety, antisocial feelings, and over the past year or so a feeling of brain fog. I was diagnosed with ADD as a child and they decided I didn’t have it 2 years later but I know I likely still do. I decided to finally give CBD from the local Rite aid a try. After 4 days I can say that the brain fog is gone. A week ago I couldn’t even explain the feeling that plagued me. I still don’t feel anything close to a normal person but I can say that I have a better ability to process my brain that I haven’t felt in years. I reccomend anyone who is interested give CBD a try. I only hope the clowns in our country can get past the marijuana BS that they try to strong along and connect to CBD.

Source: https://www.reddit.com/r/CBD/comments/jlasaf/my_experience_with_cbd/

Heartland

Anyone tried 10DollarCartridge CBD carts?

Published

3 hours ago

October 31, 2020

Republished by Plato

Visit our community site for vetted suppliers at http://theCBD.place. It’s time that this subject was given more internet exposure. We are here to discuss topics related to medical marijuana and our experiences using CBD. Please do not assume that anyone here is a medical professional.

Source: https://www.reddit.com/r/CBD/comments/jl95ga/anyone_tried_10dollarcartridge_cbd_carts/

Heartland

Anxiety and ADD?

Published

5 hours ago

October 30, 2020

Republished by Plato

I went to a doctor to try and sort out my anxiety issues, they are becoming a bit much to self manage. They put me on Prozac and it was a complete nightmare, the side effects were horrible, not to mention all of the unspoken rules that came along with it, no drinking, no ibuprofen, and countless others.

I am a regular THC user and that seems to help control my anxiety in the evenings but I obviously do not use at work which is where the problem lies.

I have issues with general anxiety, social anxiety, and add. Can CBD help me? How do I know how much to take, and do I have to keep taking it as in does it wear off ever couple hours? I dont know anything about this stuff but I know that Prozac is NOT for me!!!

Source: https://www.reddit.com/r/CBD/comments/jl7gfk/anxiety_and_add/