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Cannabidiol Regulates the Expression of Keratinocyte Proteins Involved in the Inflammation Process through Transcriptional Regulation

Cannabidiol (CBD), a natural phytocannabinoid without psychoactive effect, is a well-known anti-inflammatory and antioxidant compound. The possibility of its use in cytoprotection of cells from harmful factors, including ultraviolet (UV) radiation, is an area of ongoing investigation. Therefore, the aim of this study was to evaluate the effect of CBD on the regulatory mechanisms associated with the redox balance and inflammation in keratinocytes irradiated with UVA [30 J/cm²] and UVB [60…

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Cannabidiol (CBD), a natural phytocannabinoid without psychoactive effect, is a well-known anti-inflammatory and antioxidant compound. The possibility of its use in cytoprotection of cells from harmful factors, including ultraviolet (UV) radiation, is an area of ongoing investigation. Therefore, the aim of this study was to evaluate the effect of CBD on the regulatory mechanisms associated with the redox balance and inflammation in keratinocytes irradiated with UVA [30 J/cm2] and UVB [60 mJ/cm2]. Spectrophotometric results show that CBD significantly enhances the activity of antioxidant enzymes such as superoxide dismutase and thioredoxin reductase in UV irradiated keratinocytes. Furthermore, despite decreased glutathione peroxidase and reductase activities, CBD prevents lipid peroxidation, which was observed as a decreased level of 4-HNE and 15d-PGJ2 (measured using GC/MS and LC/MS). Moreover, Western blot analysis of protein levels shows that, under stress conditions, CBD influences interactions of transcription factors Nrf2- NFκB by inhibiting the NFκB pathway, increasing the expression of Nrf2 activators and stimulating the transcription activity of Nrf2. In conclusion, the antioxidant activity of CBD through Nrf2 activation as well as its anti-inflammatory properties as an inhibitor of NFκB should be considered during design of new protective treatments for the skin.

Keywords: NFκB; Nrf2; UV radiation; antioxidants; cannabidiol; inflammation; intracellular signaling; keratinocytes.

Source: https://pubmed.ncbi.nlm.nih.gov/31382646/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1TQbL92JdzYTve0m3OsSoggMby2JyZDVBLRHiDMYZkT1hs6YNQ&fc=20200804223051&ff=20200815134947&v=2.11.5

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What kind of pod systems can you use with cbd?

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Hey, I’ve recently started using cbd gummy’s to help with my anxiety attacks, but I’ve noticed it doesn’t take effect fast enough to really help. I want to try out vaping it but I am not really interested in using disposables. Can you use any kind of pod systems to vape eliquid?

Source: https://www.reddit.com/r/CBD/comments/l49kgi/what_kind_of_pod_systems_can_you_use_with_cbd/

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pre-made tincture are more expensive?

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I’ve been looking around for tinctures, mainly full spectrum 1000mg/30 mL. The price for this has been hovering around $60-$70 from several vendors. However as I was browsing through powders, I found 1000mg full spectrum powder for just $30 at cbdistillery, at half the cost of pre-made full spectrum tincture. Is the price difference mainly just convenience? Pre-made tinctures seem to be far more expensive than a DIY. I understand you’d need to buy a carrier oil to make a tincture, so the total cost at first purchase would be more than $30, but one would be set for making additional cbd tinctures in the future.

Source: https://www.reddit.com/r/CBD/comments/l49ga2/premade_tincture_are_more_expensive/

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Have you guys noticed any synergetic effect of drinking coffe after/before taking cbd?

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Visit our community site for vetted suppliers at http://theCBD.place. It’s time that this subject was given more internet exposure. We are here to discuss topics related to medical marijuana and our experiences using CBD. Please do not assume that anyone here is a medical professional.

Source: https://www.reddit.com/r/CBD/comments/l4749q/have_you_guys_noticed_any_synergetic_effect_of/

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