Heartland
Cannabidiol prevents haloperidol-induced vacuos chewing movements and inflammatory changes in mice via PPARγ receptors
The chronic use of drugs that reduce the dopaminergic neurotransmission can cause a hyperkinetic movement disorder called tardive dyskinesia (TD). The pathophysiology of this disorder is not entirely understood but could involve oxidative and neuroinflammatory mechanisms. Cannabidiol (CBD), the major non-psychotomimetic compound present in Cannabis sativa plant, could be a possible therapeutic alternative for TD. This phytocannabinoid shows antioxidant, anti-inflammatory and antipsychotic…

The chronic use of drugs that reduce the dopaminergic neurotransmission can cause a hyperkinetic movement disorder called tardive dyskinesia (TD). The pathophysiology of this disorder is not entirely understood but could involve oxidative and neuroinflammatory mechanisms. Cannabidiol (CBD), the major non-psychotomimetic compound present in Cannabis sativa plant, could be a possible therapeutic alternative for TD. This phytocannabinoid shows antioxidant, anti-inflammatory and antipsychotic properties and decreases the acute motor effects of classical antipsychotics. The present study investigated if CBD would attenuate orofacial dyskinesia, oxidative stress and inflammatory changes induced by chronic administration of haloperidol in mice. Furthermore, we verified in vivo and in vitro (in primary microglial culture) whether these effects would be mediated by PPARγ receptors. The results showed that the male Swiss mice treated daily for 21 days with haloperidol develop orofacial dyskinesia. Daily CBD administration before each haloperidol injection prevented this effect. Mice treated with haloperidol showed an increase in microglial activation and inflammatory mediators in the striatum. These changes were also reduced by CBD. On the other hand, the levels of the anti-inflammatory cytokine IL-10 increased in the striatum of animals that received CBD and haloperidol. Regarding oxidative stress, haloperidol induced lipid peroxidation and reduced catalase activity. This latter effect was attenuated by CBD. The combination of CBD and haloperidol also increased PGC-1α mRNA expression, a co-activator of PPARγ receptors. Pretreatment with the PPARγ antagonist, GW9662, blocked the behavioural effect of CBD in our TD model. CBD also prevented LPS-stimulated microglial activation, an effect that was also antagonized by GW9662. In conclusion, our results suggest that CBD could prevent haloperidol-induced orofacial dyskinesia by activating PPARγ receptors and attenuating neuroinflammatory changes in the striatum.
Keywords: Cannabidiol; Neuroinflammation; Oxidative stress; PPARγ receptors; Tardive dyskinesia.
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What is one of the strongest CBD in vaping form?
Visit our community site for vetted suppliers at http://theCBD.place. It’s time that this subject was given more internet exposure. We are here to discuss topics related to medical marijuana and our experiences using CBD. Please do not assume that anyone here is a medical professional.
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Source: https://www.reddit.com/r/CBD/comments/m0zvtg/what_is_one_of_the_strongest_cbd_in_vaping_form/
Heartland
Anzac Day march increased to 5000 in Sydney's CBD

Any veteran who wishes to participate in the Sydney CBD march will be required to register via the RSL NSW website.
In previous years, veterans and their descendants have not been required to register to march, with more than 12,000 taking to Sydney’s streets in 2019.
Earlier on Tuesday, Mr Morrison said he would like to see Anzac Day celebrations “return to normal as much as we possibly can”.
“I respect ultimately these are calls that have got to be made by state governments, but I want Anzac Day on,” he told reporters in Sydney.
“If people can party, and if people can protest, then we can remember as a nation and honour our veterans on Anzac Day. And I would like to see that done as fully and as safely as possible.”
In 2020, Anzac Day marches across Australia were cancelled as the nation entered strict coronavirus restrictions. In lieu of the march, “Light Up the Dawn” driveway services were held in neighbourhoods across the country.
Tuesday marked NSW’s 51st consecutive day of no locally acquired coronavirus cases.
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Source: https://www.google.com/url?rct=j&sa=t&url=https://www.smh.com.au/national/nsw/anzac-day-march-increased-to-5000-in-sydney-s-cbd-20210309-p5792r.html&ct=ga&cd=CAIyGjQ2MzM1ZTBkNWQyZmIyYzc6Y29tOmVuOlVT&usg=AFQjCNGJKXeFEPybOePsWcm_wHfdMbTZww
Heartland
Anzac Day march increased to 5000 in Sydney's CBD
The Anzac Day march in Sydney's CBD will be capped at 5000 after RSL NSW reached an agreement with the NSW government and police to … Checkout PrimeXBT
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