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Cannabidiol in the Treatment of Post-Traumatic Stress Disorder: A Case Series

CONCLUSIONS: Administration of oral CBD in addition to routine psychiatric care was associated with PTSD symptom reduction in adults with PTSD. CBD also appeared to offer relief in a subset of patients who reported frequent nightmares as a symptom of their PTSD. Additional clinical investigation, including double-blind, placebo-controlled trials, would be necessary to further substantiate the response to CBD that was observed in this study.

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Objectives: Cannabidiol (CBD) is a non-psychotomimetic cannabinoid compound that is found in plants of the genus Cannabis. Preclinical research has suggested that CBD may have a beneficial effect in rodent models of post-traumatic stress disorder (PTSD). This effect is believed to be due to the action of CBD on the endocannabinoid system. CBD has seen a recent surge in research regarding its potential value in a number of neuro-psychiatric conditions. This is the first study to date examining the clinical benefit of CBD for patients with PTSD.

Methods: This retrospective case series examines the effect of oral CBD administration on symptoms of PTSD in a series of 11 adult patients at an outpatient psychiatry clinic. CBD was given on an open-label, flexible dosing regimen to patients diagnosed with PTSD by a mental health professional. Patients also received routine psychiatric care, including concurrent treatment with psychiatric medications and psychotherapy. The length of the study was 8 weeks. PTSD symptom severity was assessed every 4 weeks by patient-completed PTSD Checklist for the DSM-5 (PCL-5) questionnaires.

Results: From the total sample of 11 patients, 91% (n = 10) experienced a decrease in PTSD symptom severity, as evidenced by a lower PCL-5 score at 8 weeks than at their initial baseline. The mean total PCL-5 score decreased 28%, from a mean baseline score of 51.82 down to 37.14, after eight consecutive weeks of treatment with CBD. CBD was generally well tolerated, and no patients discontinued treatment due to side effects.

Conclusions: Administration of oral CBD in addition to routine psychiatric care was associated with PTSD symptom reduction in adults with PTSD. CBD also appeared to offer relief in a subset of patients who reported frequent nightmares as a symptom of their PTSD. Additional clinical investigation, including double-blind, placebo-controlled trials, would be necessary to further substantiate the response to CBD that was observed in this study.

Keywords: PTSD; anxiety; cannabidiol; cannabis; nightmares; post-traumatic stress disorder.

Source: https://pubmed.ncbi.nlm.nih.gov/30543451/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1LgINZmdEb7hTii13TOa5DGOR2cvkVQ2sw4N7-xSaEiod6ucE1&fc=20200804221722&ff=20200815071104&v=2.11.5

Heartland

Questions about AVD carts

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I’m relatively new to CBD and i’ve just gotten my order from hemp barn and i was surprised to see i receieved an avd cart rather than a ccell my questions are:

  1. is avd better than ccells?

  2. What voltage should I run avd carts at? It hits weaker than my last cart

  3. Is my avd disposable cart refillable?

Source: https://www.reddit.com/r/CBD/comments/jlpa2v/questions_about_avd_carts/

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Heartland

Trump’s Department of Justice Is Harassing Legal Weed Companies Because Bill Barr Hates Pot

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A DOJ whistleblower says that because of Barr’s personal antipathy toward cannabis, the department is deliberately harassing legal cannabis companies with pointless investigations. The top brass around Barr knows that these probes are absolutely bogus.

Source: https://www.reddit.com/r/CBD/comments/jlp467/trumps_department_of_justice_is_harassing_legal/

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Heartland

CBD, Abilify? Will it interact with 2.5mg a day

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My doc is ant-cannabis she sees no medicinal value in cannabis. I don’t smoke weed and that’s the only med I’m taking. Thought maybe some other people in a similar situation could give me some info. I know it’s metabolised by the same enzyme I don’t want a build up of Abilify although with a so low dose does it matter is my question?

Source: https://www.reddit.com/r/CBD/comments/jlogep/cbd_abilify_will_it_interact_with_25mg_a_day/

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