Connect with us

Heartland

Cannabidiol Does Not Convert to Δ9-Tetrahydrocannabinol in an In Vivo Animal Model

Introduction: Cannabidiol (CBD) can convert to Δ⁹-tetrahydrocannabinol (THC) in vitro with prolonged exposure to simulated gastric fluid; however, in vitro conditions may not be representative of the in vivo gut environment. Using the minipig, we investigated whether enteral CBD converts to THC in vivo. Materials and Methods: Synthetic CBD (100 mg/mL) was administered orally in a sesame oil formulation twice daily to minipigs (N=3) in 15 mg/kg doses for 5 consecutive days. Blood samples were…

Republished by Plato

Published

on

Introduction: Cannabidiol (CBD) can convert to Δ9-tetrahydrocannabinol (THC) in vitro with prolonged exposure to simulated gastric fluid; however, in vitro conditions may not be representative of the in vivo gut environment. Using the minipig, we investigated whether enteral CBD converts to THC in vivo. Materials and Methods: Synthetic CBD (100 mg/mL) was administered orally in a sesame oil formulation twice daily to minipigs (N=3) in 15 mg/kg doses for 5 consecutive days. Blood samples were taken before and 1, 2, 4, and 6 h after morning doses on Days 1 and 5. Six hours after the final dose on Day 5, the animals were euthanized, and samples of gastrointestinal (GI) tract contents were obtained. Liquid chromatography with tandem mass spectrometry analysis determined CBD, THC, and 11-hydroxy-THC (11-OH-THC) concentrations. Lower limits of quantification: plasma CBD=1 ng/mL, plasma THC and 11-OH-THC=0.5 ng/mL, GI tract CBD=2 ng/mL, and GI tract THC and 11-OH-THC=1 ng/mL. Results: THC and 11-OH-THC were undetectable in all plasma samples. Maximum plasma concentrations (Cmax) of CBD were observed between 1 and 4 h on Days 1 and 5. CBD was present in plasma 6 h after administration on Days 1 (mean 33.6 ng/mL) and 5 (mean 98.8 ng/mL). Mean Cmax CBD values, 328 ng/mL (Day 1) and 259 ng/mL (Day 5), were within range of those achieved in clinical studies. Mean CBD exposure over 6 h was similar on Days 1 (921 h·ng/mL) and 5 (881 h·ng/mL). THC and 11-OH-THC were not detected in all GI tract samples. Mean CBD concentrations reached 84,500 ng/mL in the stomach and 43,900 ng/mL in the small intestine. Conclusions: Findings of the present study show that orally dosed CBD, yielding clinically relevant plasma exposures, does not convert to THC in the minipig, a species predictive of human GI tract function.

Keywords: cannabidiol; conversion; minipig; tetrahydrocannabinol.

Source: https://pubmed.ncbi.nlm.nih.gov/29285522/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1TUbR4JfRTv1rbahLd1HaiF0w5ryO5ocWB3_xk3Prq78L0AEhI&fc=20200804222312&ff=20200817013501&v=2.11.5

Heartland

CBD increases sex drive?

Republished by Plato

Published

on

Visit our community site for vetted suppliers at http://theCBD.place. It’s time that this subject was given more internet exposure. We are here to discuss topics related to medical marijuana and our experiences using CBD. Please do not assume that anyone here is a medical professional.

Source: https://www.reddit.com/r/CBD/comments/jhcl3v/cbd_increases_sex_drive/

Continue Reading

Heartland

PSA for anyone using CBD, it acts like grapefruit juice [CYP450 enzyme]

Republished by Plato

Published

on

Visit our community site for vetted suppliers at http://theCBD.place. It’s time that this subject was given more internet exposure. We are here to discuss topics related to medical marijuana and our experiences using CBD. Please do not assume that anyone here is a medical professional.

Source: https://www.reddit.com/r/CBD/comments/jhbybu/psa_for_anyone_using_cbd_it_acts_like_grapefruit/

Continue Reading

Heartland

Does CBD go bad?

Republished by Plato

Published

on

Long story short my mailman put my package containing a lazarus naturals tincture in the wrong locker. It was in there for probably a month in the Texas heat. Do you guys think it is still good? Im hoping so because no it is a large bottle!

Thank you in advance

Source: https://www.reddit.com/r/CBD/comments/jhak23/does_cbd_go_bad/

Continue Reading
Heartland4 days ago

Web site credit card processing

Manufacturing3 days ago

New and Noteworthy Categories on Thomasnet.com for October 2020

Heartland3 days ago

CBG Study Shows Antimicrobial Properties of Cannabis

Heartland3 days ago

Medical Marijuana: 7 Incredible Health Benefits for Women

Heartland2 days ago

German Cannabis Flower Market is Ready to Explode

CBD5 days ago

CBD and Geriatric Medicine: Should Seniors Take CBD?

Heartland4 days ago

CBG tinctures

Heartland3 days ago

Thanks to these CBD “cigarettes” I am a full week tobacco/nicotine free 🎉

Heartland4 days ago

Find your perfect sleep system

Heartland2 days ago

Cybin Raises C$45 Million: The Largest Go Public Capital Raise in the Canadian Psychedelic Sector

Heartland19 hours ago

Medical Experts Discuss Uses of CBD (via JAMA — Top Medical Journal)

Heartland3 days ago

Question on CBD vs CBG

Heartland2 days ago

Dosage for CBG/CBD tincture from LN?

Manufacturing4 days ago

Look ! so lovely and warm smile@v@

Heartland3 days ago

Will I get high from a gummy with 4.5 mg cbd and .5 mg thc? I have no tolerance.

Heartland5 days ago

The Daily Hit: October, 19th 2020

Material4 days ago

Tribological characteristics of graphite epoxy composites using adhesive wear experiments

Heartland2 days ago

Indus Holdings, Inc. Welcomes Bruce Gates to Board of Directors; Announces Results of Annual Shareholder Meeting

Heartland3 days ago

National Cannabis Lobbying Falls, Again

CBD22 hours ago

CBD News Roundup: NFLPA Warns Players Not to Endorse CBD

Heartland4 days ago

First Ever Harvest 🎃😈 15 Autos hanging to dry!

Heartland3 days ago

In need of some honest advice/opinions concerning the use of thc as a maladaptive coping mechanism and the use of cbd to combat it

Heartland3 days ago

Any success stories with smoking cessation?

Heartland3 days ago

BZA denies permit for hemp facility on Poplar

Heartland3 days ago

Anyone begin CBD as a skeptic?

Heartland19 hours ago

CBD is a life-saver for me.

Heartland5 days ago

Brand Spotlight: Cannabiotix

Heartland5 days ago

Just bought pre-rolls of hemp flower at a new head shop in Kentucky. The guy said they just legalized the sale of hemp flower like a month ago so they can sell it now but can’t find anything about it on the internet. Is it legal for me to own these?

Material4 days ago

The inhibitive action of Calendula officinalis flower heads extract for mild steel corrosion in 1 M HCl solution

News3 days ago

The First Medical Cannabis Dispensary in Virginia has Opened its Doors

Trending

A Cloud Nine Capital Entity Copyright © 2020 – All Rights Reserved Proudly Made in America