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Cannabidiol Derivative May Be Effective as EB Treatment, Studies Suggest

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A modified version of cannabidiol has potent antioxidant and anti-inflammatory properties that may help to treat epidermolysis bullosa (EB), research suggests.

Cannabidiol, or CBD, is one of the most studied active chemicals — called cannabinoids — of the cannabis plant. CBD is devoid of the mind-altering effects linked with cannabis, and has antioxidant and anti-inflammatory properties that make it increasingly of interest as a therapy for several disorders, including EB.

But the mechanism of action underlying the therapeutic effects of CBD in skin diseases is unclear.

In the study “Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1,” published in the journal Redox Biologyresearchers at the University of Cordoba, in Spain, and the University of Dundee, in Scotland, incubated the main cells of the top layer of the skin, called keratinocytes, with CBD for 24 hours and them compared them with untreated cells serving as controls.

The team looked at how the cell’s transcriptome — the entire set of messenger RNA molecules that carry the information needed to convert DNA into proteins — and proteome (all proteins) changed after treatment with CBD.

Their analysis revealed that CBD may promote the proliferation and maturation of keratinocytes, as well as pathways important for skin development. Such results were confirmed in mice.

One of the genes activated by CBD was HMOX1, which codes for a protein called heme oxygenase 1. This enzyme has antioxidant and anti-inflammatory properties in the skin. Further experiments showed that CBD led to the degradation of a protein called BACH1, which acts as a repressor of HMOX1.

Once the mechanism was clear, the researchers developed tweaked forms of CBD with enhanced antioxidant and anti-inflammatory effects.

“Once we described the whole working mechanism, we have continued our partnership, making modifications to the cannabidiol molecule in order to try to improve its properties that fight against skin diseases,” Eduardo Muñoz, a professor of immunology and the lead investigator of the research group at the University of Cordoba, said in a press release.

The team developed a derivative of CBD that not only blocks the action of BACH1 but also promotes the activity of the NRF2 protein, a master regulator of genes with antioxidant activity.

In the subsequent study “Isomeric O-methyl cannabidiolquinones with dual BACH1/NRF2 activity,” published in the same journal, these researchers showed that the new CBD derivative stabilized the NRF2 protein and induced HMOX1 activity. Cells models of Huntington’s disease, characterized by inflammation and oxidative stress, showed that this derivative of CBD has antioxidant properties and may also be beneficial in countering some effects of aging.

As a side note, oxidative stress is caused by an imbalance between the production of potentially harmful reactive oxygen species and antioxidant defenses.

“When combining the inhibition of BACH1 with the activation of NRF2, the result is a very potent antioxidant and anti-inflammatory response and better therapeutic effects,” Muñoz said.

Planned future research includes continuing to tweak the CBD-derived molecules, and to test them in animal models of skin diseases and other inflammatory disorders.

This work at the University of Cordoba led to the creation of Emerald Health Biotechnology and Innohealth Madrid, now part of Evonik Industries, which also collaborated in initial steps of the research.­­

Patricia holds her Ph.D. in Cell Biology from University Nova de Lisboa, and has served as an author on several research projects and fellowships, as well as major grant applications for European Agencies. She also served as a PhD student research assistant in the Laboratory of Doctor David A. Fidock, Department of Microbiology & Immunology, Columbia University, New York.

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José holds a PhD in Neuroscience from Universidade of Porto, in Portugal. He has also studied Biochemistry at Universidade do Porto and was a postdoctoral associate at Weill Cornell Medicine, in New York, and at The University of Western Ontario in London, Ontario, Canada. His work has ranged from the association of central cardiovascular and pain control to the neurobiological basis of hypertension, and the molecular pathways driving Alzheimer’s disease.

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Patricia holds her Ph.D. in Cell Biology from University Nova de Lisboa, and has served as an author on several research projects and fellowships, as well as major grant applications for European Agencies. She also served as a PhD student research assistant in the Laboratory of Doctor David A. Fidock, Department of Microbiology & Immunology, Columbia University, New York.

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Never been a “flavored” CBD person but the hint of mint in this product is not bad.

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Visit our community site for vetted suppliers at http://theCBD.place. It’s time that this subject was given more internet exposure. We are here to discuss topics related to medical marijuana and our experiences using CBD. Please do not assume that anyone here is a medical professional.

Source: https://www.reddit.com/r/CBD/comments/l2fnmg/never_been_a_flavored_cbd_person_but_the_hint_of/

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Minty taste when vaping CBD isolate?

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I have plenty of experience using CBD flower and tinctures, etc. but I just recently purchased and vaped pure CBD isolate for the first time. I used my large dab rig and was expecting no taste or flavor profile since there are no terpenes but was surprised when I was met with a somewhat strong spearmint aftertaste. It even made the room smell minty. Is this normal? I purchased from a very reputable company that I have been buying various other nootropics from for years and received lab results with my order.

Source: https://www.reddit.com/r/CBD/comments/l2bzgt/minty_taste_when_vaping_cbd_isolate/

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Help with sleep

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Hi all,

I’ve been a fairly heavy cannabis smoker for about 5 years now, I’d say atleast 1g a day with the odd day off here and there due to either not being able to source any or not being able to afford any. My problem is I really struggle to sleep without a joint before bed, I also struggle to not smoke all day on my days off which is an issue not just from the usage standpoint but also productivity.

I’ve had quite a lot going on this past couple of years especially, I lost my business, was forced to move out of my parents into a flat with my brother (we always smoked together) he then bailed to live with a friend in a much nicer apartment, which while I prefer this it has made my anxiety much worse as it’s a struggle to afford the bills (They always come before weed regardless) which all together is making it difficult to sleep without either having a nice joint or having a few glasses of whiskey. Which is part the reason I’m looking for advice as I know I have an addictive personality, and I don’t really want to end developing an alcohol problem.

I have read a few contradictory articles online about CBD and sleep so I’m hoping you guys could help me out with some educated information haha, or any alternatives all the same I’d appreciate the help. TIA!

Source: https://www.reddit.com/r/CBD/comments/l2awoc/help_with_sleep/

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