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Cannabidiol (CBD) reduces anxiety-related behavior in mice via an FMRP-independent mechanism

Fragile X Syndrome is a neurodevelopmental disorder which affects intellectual, social and physical development due to mutation of the Fragile X mental retardation 1 (FMR1) gene. The resultant loss of Fragile X mental retardation protein can be modelled by Fmr1 gene knockout (KO) in mice. The current study investigated the behavioural effects of cannabidiol (CBD; a non-psychoactive phytocannabinoid) in male Fmr1 KO mice as a preclinical model for therapeutic discovery. Vehicle or CBD (5 or 20…

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Fragile X Syndrome is a neurodevelopmental disorder which affects intellectual, social and physical development due to mutation of the Fragile X mental retardation 1 (FMR1) gene. The resultant loss of Fragile X mental retardation protein can be modelled by Fmr1 gene knockout (KO) in mice. The current study investigated the behavioural effects of cannabidiol (CBD; a non-psychoactive phytocannabinoid) in male Fmr1 KO mice as a preclinical model for therapeutic discovery. Vehicle or CBD (5 or 20 mg/kg body weight) was administered to adult Fmr1 KO and wild type-like (WT) mice before they were tested in behavioural tasks including: open field (OF), elevated plus maze (EPM), spontaneous alternation, social preference, and passive avoidance tasks. Fmr1 KO mice were hyperlocomotive and hyperexplorative and habituated more slowly to a novel environment compared to control animals. Furthermore, Fmr1 KO mice showed fewer anxiety-related behaviours across tests. Effects of CBD were subtle and limited to the EPM, where CBD decreased the anxiety response of all mice tested. Acute CBD had no impact on locomotion or anxiety-related parameters in the OF. Cognitive performance of Fmr1 KO mice was equivalent to controls and not affected by CBD treatment. Brain concentrations of CBD were equivalent between genotypes, but in animals sacrificed 90 min post-administration, decreased plasma CBD in Fmr1 KO mice compared to WT suggested more rapid clearance of CBD by transgenic animals. Overall, acute CBD at the doses chosen did not selectively normalize behavioural abnormalities in Fmr1 KO mice, but reduced anxiety-like behaviour in both Fmr1 KO and WT mice.

Keywords: Anxiety; Cannabidiol (CBD); Cognition; Fragile X syndrome; Locomotion; Mouse model; Social behaviours.

Source: https://pubmed.ncbi.nlm.nih.gov/31063743/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1LgINZmdEb7hTii13TOa5DGOR2cvkVQ2sw4N7-xSaEiod6ucE1&fc=20200804221722&ff=20200814111229&v=2.11.5

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Would I get the same feeling throughout the day if I was to put about 10 drops of CBD 15 or 20 times a day instead of the recommend amount twice a day?

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Visit our community site for vetted suppliers at http://theCBD.place. It’s time that this subject was given more internet exposure. We are here to discuss topics related to medical marijuana and our experiences using CBD. Please do not assume that anyone here is a medical professional.

Source: https://www.reddit.com/r/CBD/comments/lusau9/would_i_get_the_same_feeling_throughout_the_day/

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What type of CBD or anxiety/panic attacks?

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I have one brand I got years ago and didn’t really think it did much for me. I see there are different types like broad spectrum. I have anxiety and sometimes panic attacks when driving or having to go to the dentist. I’ve been researching and there are a wealth of brands. I’m a bit overwhelmed. Any advice?

Source: https://www.reddit.com/r/CBD/comments/lurxkx/what_type_of_cbd_or_anxietypanic_attacks/

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Anyone recently fly with CBD oil/vapes?

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I know this question has been asked a couple times on here, but just want to be sure. Going to be in Florida for a week, and really don’t want to have to leave it behind. Has been doing wonders for my anxiety. Guess I’m more worried about the vape- I’ve got one right now from Steve’s Goods that smells a little strong of terps.

Source: https://www.reddit.com/r/CBD/comments/luro9r/anyone_recently_fly_with_cbd_oilvapes/

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