Heartland
Cannabidiol Attenuates Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis Through Induction of Myeloid-Derived Suppressor Cells
Multiple sclerosis (MS) is a chronic debilitating autoimmune disease without a cure. While the use of marijuana cannabinoids for MS has recently been approved in some countries, the precise mechanism of action leading to attenuate neuroinflammation is not clear. We used experimental autoimmune encephalomyelitis (EAE), a murine model of MS, to explore the anti-inflammatory properties of cannabidiol (CBD), a non-psychoactive cannabinoid. Treatment with CBD caused attenuation of EAE disease…

Multiple sclerosis (MS) is a chronic debilitating autoimmune disease without a cure. While the use of marijuana cannabinoids for MS has recently been approved in some countries, the precise mechanism of action leading to attenuate neuroinflammation is not clear. We used experimental autoimmune encephalomyelitis (EAE), a murine model of MS, to explore the anti-inflammatory properties of cannabidiol (CBD), a non-psychoactive cannabinoid. Treatment with CBD caused attenuation of EAE disease paradigms as indicated by a significant reduction in clinical scores of paralysis, decreased T cell infiltration in the central nervous system, and reduced levels of IL-17 and IFNγ. Interestingly, CBD treatment led to a profound increase in myeloid-derived suppressor cells (MDSCs) in EAE mice when compared to the vehicle-treated EAE controls. These MDSCs caused robust inhibition of MOG-induced proliferation of T cells in vitro. Moreover, adoptive transfer of CBD-induced MDSCs ameliorated EAE while MDSC depletion reversed the beneficial effects of CBD treatment, thereby conclusively demonstrating that MDSCs played a crucial role in CBD-mediated attenuation of EAE. Together, these studies demonstrate for the first time that CBD treatment may ameliorate EAE through induction of immunosuppressive MDSCs.
Keywords: autoimmunity; cannabidiol; experimental autoimmune encephalomyelitis; inflammation; marijuana; microRNA; multiple sclerosis; myeloid-derived suppressor cells.
-
Heartland1 week ago
CBD Oil for Dogs With Seizures: The Ultimate Guide
-
Heartland1 week ago
Ag. secy. seeks grants to boost hemp sales
-
Heartland1 week ago
Biochemical aspects of seeds from Cannabis sativa L. plants grown in a mountain environment
-
Heartland1 week ago
Humboldt County, California, permanently bans hemp cultivation
-
News1 week ago
Fiore Cannabis Announces Sale of Surplus Cannabis Licence to Fund Expansion of Apex Cultivation Facility
-
News1 week ago
TILT Holdings Provides Preliminary Fourth Quarter Results, Operational Highlights and 2021 Outlook
-
Uncategorized1 week ago
How to Apply for a Massachusetts Cannabis License
-
News1 week ago
SpeakEasy Announces Closing of $4,302,500 Million Non-Brokered Private Placement