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Metal

Boosting the photodynamic therapy efficiency by using stimuli-responsive and AIE-featured nanoparticles

Abstract: Photosensitizers with aggregation-induced emission (AIE) characteristics are of great interest for cancer theranostics involving both fluorescence imaging and photodynamic therapy (PDT). However, in the purpose of clinical trials of PDT, the development of prominent drug delivery systems for boosting the PDT efficiency of AIE photosensitizers is highly desirable but still remain a challenging task. Herein, a novel strategy is designed and performed for boosting PDT effect based on stimuli-responsive nano-micelles as extraordinary carriers for an AIE photosensitizer, namely MeTTMN. Those presented stimuli-responsive nano-micelles loading MeTTMN exhibit good biocompatibility, excellent stability, appropriate nanoparticle size, high loading efficiency, outstanding imaging quality and significantly promoted PDT performance, eventually making them remarkably impressive and significantly superior to commercially available nano-micelles carried MeTTMN. This study thus offers an ideal template for fluorescence imaging-guided PDT, as well as a promising candidate for clinical trials.

https://doi.org/10.1016/j.biomaterials.2019.119749

Boosting the photodynamic therapy efficiency by using stimuli-responsive and AIE-featured nanoparticles

READ THE FULL TEXT ON SCIENCEDIRECT

Republished by Plato

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Abstract: Photosensitizers with aggregation-induced emission (AIE) characteristics are of great interest for cancer theranostics involving both fluorescence imaging and photodynamic therapy (PDT). However, in the purpose of clinical trials of PDT, the development of prominent drug delivery systems for boosting the PDT efficiency of AIE photosensitizers is highly desirable but still remain a challenging task. Herein, a novel strategy is designed and performed for boosting PDT effect based on stimuli-responsive nano-micelles as extraordinary carriers for an AIE photosensitizer, namely MeTTMN. Those presented stimuli-responsive nano-micelles loading MeTTMN exhibit good biocompatibility, excellent stability, appropriate nanoparticle size, high loading efficiency, outstanding imaging quality and significantly promoted PDT performance, eventually making them remarkably impressive and significantly superior to commercially available nano-micelles carried MeTTMN. This study thus offers an ideal template for fluorescence imaging-guided PDT, as well as a promising candidate for clinical trials.

https://doi.org/10.1016/j.biomaterials.2019.119749

Boosting the photodynamic therapy efficiency by using stimuli-responsive and AIE-featured nanoparticles

READ THE FULL TEXT ON SCIENCEDIRECT Source: https://www.materialstoday.com/biomaterials/features/boosting-the-photodynamic-therapy-efficiency/

Metal

Ex-CIS BPI price hits new high in fresh booking to US

By the end of week, a basic pig iron supplier succeeded in booking material at a new high.

Republished by Plato

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Information Provided By:

SteelOrbis Elektronik Pazaryeri A.Ş. (“SteelOrbis”)
19 Mayıs Mahallesi, Atatürk Caddesi
Şeref Yazgan İş Merkezi, No: 72, Kat: 7, D: 18
Kozyatağı – 34736
Istanbul, Turkey

Trade Registration Number : 541892
MERSİS Number : 0470048178400014
Customer Relations Officer : Sinem Alpkaya
Tel : +90 216 468 10 50
Fax : +90 216 386 41 08

This Information Form has been drawn up in order to provide information to the customer (“Customer”) who seeks a free trial on an electronic environment for the purpose of benefiting from the services offered by the SteelOrbis website at “www.steelorbis.com” prior to acceptance of the Membership Contract, and it allows the Customer to gain clear information on the terms and conditions of the membership to be established as well as to review the text of the Contract in question.

The following successive steps shall be taken in order to establish a free trial:

– The Customer selects the “Free Trial” option on the home page at https://www.steelorbis.com.
– The Customer provides all information requested in the “Free Trial Application” form displayed on the screen and confirms it.
– SteelOrbis sends an account activation e-mail to the e-mail address of the Customer provided in the application form.
– The Customer clicks on the activation link sent to his/her e-mail address and activates his/her account. The website Membership Contract is presented to the Customer during the account activation process.

Storage of the Membership Contract:

You can either save the Membership Contract on your computer or make print-outs of it for storage. The Membership Contract accepted and confirmed by the Customer is not kept by SteelOrbis. You can always get access to the standard Membership Contract displayed on the website. However, as amendments may be made to the standard Contract, it may include some variations in comparison with the text approved by you. Accordingly, it may not be possible for you to access on the website the text you originally approved.

Data entry errors:

The information you should provide for membership application and the fields you should fill in are indicated during each step of the operation. You are obliged to provide such information. If you leave the required fields blank, the system will issue a warning. Please fill in all necessary fields. Prior to the completion of the operation, all data entered by you in the previous step will be displayed once more. Please make sure that the information provided by you is accurate and complete before finally confirming the operation; any missing or incorrect information should be completed or corrected. Any amendment or correction on the information provided by you after the confirmation may be performed by means of website logins after the establishment of the membership.

Our confidentiality policy:

Please click here to review our confidentiality policy.

Source: https://www.steelorbis.com/steel-prices/steel-prices-market-analyses/scrap-and-raw-materials/ex_cis-bpi-price-hits-new-high-in-fresh-booking-to-us-1174350.htm

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Metal

Chinese manganese ore prices mostly stable, with some slight downticks

Chinese domestic manganese ore prices have followed a mostly stable trend during the past week.

Republished by Plato

Published

on


Information Provided By:

SteelOrbis Elektronik Pazaryeri A.Ş. (“SteelOrbis”)
19 Mayıs Mahallesi, Atatürk Caddesi
Şeref Yazgan İş Merkezi, No: 72, Kat: 7, D: 18
Kozyatağı – 34736
Istanbul, Turkey

Trade Registration Number : 541892
MERSİS Number : 0470048178400014
Customer Relations Officer : Sinem Alpkaya
Tel : +90 216 468 10 50
Fax : +90 216 386 41 08

This Information Form has been drawn up in order to provide information to the customer (“Customer”) who seeks a free trial on an electronic environment for the purpose of benefiting from the services offered by the SteelOrbis website at “www.steelorbis.com” prior to acceptance of the Membership Contract, and it allows the Customer to gain clear information on the terms and conditions of the membership to be established as well as to review the text of the Contract in question.

The following successive steps shall be taken in order to establish a free trial:

– The Customer selects the “Free Trial” option on the home page at https://www.steelorbis.com.
– The Customer provides all information requested in the “Free Trial Application” form displayed on the screen and confirms it.
– SteelOrbis sends an account activation e-mail to the e-mail address of the Customer provided in the application form.
– The Customer clicks on the activation link sent to his/her e-mail address and activates his/her account. The website Membership Contract is presented to the Customer during the account activation process.

Storage of the Membership Contract:

You can either save the Membership Contract on your computer or make print-outs of it for storage. The Membership Contract accepted and confirmed by the Customer is not kept by SteelOrbis. You can always get access to the standard Membership Contract displayed on the website. However, as amendments may be made to the standard Contract, it may include some variations in comparison with the text approved by you. Accordingly, it may not be possible for you to access on the website the text you originally approved.

Data entry errors:

The information you should provide for membership application and the fields you should fill in are indicated during each step of the operation. You are obliged to provide such information. If you leave the required fields blank, the system will issue a warning. Please fill in all necessary fields. Prior to the completion of the operation, all data entered by you in the previous step will be displayed once more. Please make sure that the information provided by you is accurate and complete before finally confirming the operation; any missing or incorrect information should be completed or corrected. Any amendment or correction on the information provided by you after the confirmation may be performed by means of website logins after the establishment of the membership.

Our confidentiality policy:

Please click here to review our confidentiality policy.

Source: https://www.steelorbis.com/steel-prices/steel-prices-market-analyses/scrap-and-raw-materials/chinese-manganese-ore-prices-mostly-stable-with-some-slight-downticks-1174347.htm

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Metal

Tokyo Steel hikes scrap prices for two assets, ex-Japan prices still rallying

Tokyo Steel has announced a further increase in its local scrap purchase prices by JPY 500-1,000/mt ($4.8-9.6/mt) for two of its assets.

Republished by Plato

Published

on


Information Provided By:

SteelOrbis Elektronik Pazaryeri A.Ş. (“SteelOrbis”)
19 Mayıs Mahallesi, Atatürk Caddesi
Şeref Yazgan İş Merkezi, No: 72, Kat: 7, D: 18
Kozyatağı – 34736
Istanbul, Turkey

Trade Registration Number : 541892
MERSİS Number : 0470048178400014
Customer Relations Officer : Sinem Alpkaya
Tel : +90 216 468 10 50
Fax : +90 216 386 41 08

This Information Form has been drawn up in order to provide information to the customer (“Customer”) who seeks a free trial on an electronic environment for the purpose of benefiting from the services offered by the SteelOrbis website at “www.steelorbis.com” prior to acceptance of the Membership Contract, and it allows the Customer to gain clear information on the terms and conditions of the membership to be established as well as to review the text of the Contract in question.

The following successive steps shall be taken in order to establish a free trial:

– The Customer selects the “Free Trial” option on the home page at https://www.steelorbis.com.
– The Customer provides all information requested in the “Free Trial Application” form displayed on the screen and confirms it.
– SteelOrbis sends an account activation e-mail to the e-mail address of the Customer provided in the application form.
– The Customer clicks on the activation link sent to his/her e-mail address and activates his/her account. The website Membership Contract is presented to the Customer during the account activation process.

Storage of the Membership Contract:

You can either save the Membership Contract on your computer or make print-outs of it for storage. The Membership Contract accepted and confirmed by the Customer is not kept by SteelOrbis. You can always get access to the standard Membership Contract displayed on the website. However, as amendments may be made to the standard Contract, it may include some variations in comparison with the text approved by you. Accordingly, it may not be possible for you to access on the website the text you originally approved.

Data entry errors:

The information you should provide for membership application and the fields you should fill in are indicated during each step of the operation. You are obliged to provide such information. If you leave the required fields blank, the system will issue a warning. Please fill in all necessary fields. Prior to the completion of the operation, all data entered by you in the previous step will be displayed once more. Please make sure that the information provided by you is accurate and complete before finally confirming the operation; any missing or incorrect information should be completed or corrected. Any amendment or correction on the information provided by you after the confirmation may be performed by means of website logins after the establishment of the membership.

Our confidentiality policy:

Please click here to review our confidentiality policy.

Source: https://www.steelorbis.com/steel-prices/steel-prices-market-analyses/scrap-and-raw-materials/tokyo-steel-hikes-scrap-prices-for-two-assets-ex_japan-prices-still-rallying-1174340.htm

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