Connect with us

Heartland

Biological effects of Cannabidiol on normal human healthy cell populations: Systematic review of the literature

A systematic review was performed to evaluate the biological effects of Cannabidiol (CBD), one of the major components of Cannabis Sativa, on normal human healthy cell populations in terms of cell viability, proliferation, migration, apoptosis and inflammation. Inclusion criteria were: studies on cell lines and primary cell culture from healthy donors, CBD exposure as variable, no CBD exposure as control and published in English language. Quality assessment was based on ToxR tool, with a score…

Republished by Plato

Published

on

A systematic review was performed to evaluate the biological effects of Cannabidiol (CBD), one of the major components of Cannabis Sativa, on normal human healthy cell populations in terms of cell viability, proliferation, migration, apoptosis and inflammation. Inclusion criteria were: studies on cell lines and primary cell culture from healthy donors, CBD exposure as variable, no CBD exposure as control and published in English language. Quality assessment was based on ToxR tool, with a score of reliability ranging from 15 to 18.Following the PRISMA statement, three independent reviewers performed both a manual and an electronic search using MEDLINE via PubMed, Scopus, Web of Science and Cochrane. From a total of 9437eligible articles, 29 studies have been selected. The average quality assessment score was 16.48.Theresults showed heterogeneous CBD concentration exposure (0.01-50 μM or 0.1 nmol/mL-15 mg/mL). The definition of a threshold limit would allow the identification of specific effects on expected outcomes. From the data obtained CBD resulted to inhibit cell viability in a dose-dependent manner above 2 μM, while in oral cell populations the inhibitory concentration is higher than 10 μM. Moreover, it was observed a significantly inhibition of cell migration and proliferation. On the contrary, it was highlighted a stimulation of apoptosis only at high doses (from 10 μM).Finally, CBD produced an anti-inflammatory effect, with a reduction of the pro-inflammatory cytokine gene expression and secretion. CBD down-regulated ROS production, although at high concentrations (16 μM) increased ROS-related genes expression. The diffusion of CBD for therapeutic and recreational uses require a precise definition of its potential biological effects. A thorough knowledge of these aspects would allow a safe use of this substance without any possible side effects.

Keywords: Apoptosis; Cannabidiol; Cell viability; In vitro study; Inflammation.

Source: https://pubmed.ncbi.nlm.nih.gov/33038581/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1zmroqAMnEquTZFTfdGx1V1gPEavo-Be3-FKTecJpOlB7LykCL&fc=20200804213506&ff=20201011021357&v=2.12.3

Heartland

Republished by Plato

Published

on

Source:

Continue Reading

Heartland

Republished by Plato

Published

on

Source:

Continue Reading

Heartland

Republished by Plato

Published

on

Source:

Continue Reading
Heartland3 days ago

Florida Bill Aims to Legalize Medical Magic Mushrooms

Heartland4 days ago

Affordable cbd oil?

Material4 days ago

Nanocrystallization of a Ti40 cladding layer by ultrasonic impact to improve burn resistance

Heartland3 days ago

Delta 8: Shipping Vape Ban Goes Into Effect Soon – What Does It Means?

Metal3 days ago

Local Turkish DKP grade scrap prices remain stable

Heartland2 days ago

Explained: How CBD Oil is Different Than CBD Capsule?

Material4 days ago

Investigation of severe lunar environmental conditions on the physical and mechanical properties of lunar regolith geopolymers

Material4 days ago

Wear behavior of nanostructured carbo-austempered cast steels under rolling-sliding conditions

Heartland4 days ago

Heartland5 days ago

Material4 days ago

Dielectric properties and potential applications of alizarin yellow GG-Cu(II) complex film blended with polyvinyl alcohol

Material3 days ago

Chemical attack and corrosion resistance of concrete prepared with electrolyzed water

Heartland5 days ago

Perfect harmony blended with an inked soul, Craig Cavanagh to create sensations in the mind

Manufacturing4 days ago

What can I use besides injection moulding?

Material4 days ago

A method for estimating superplastic material parameters via free–inflation tests

Heartland4 days ago

CBD and Inflammation

Heartland3 days ago

Bermuda Prepares To Lock Horns With United Kingdom Over Adult Use Cannabis

Manufacturing5 days ago

Making a Yellow Taxi Toplight

Heartland4 days ago

Unnamed Company Tried to Buy Aphria While It Was Negotiating Tilray Merger

Material3 days ago

Growth kinetics of the FeB/Fe2B boride layer on the surface of 4Cr5MoSiV1 steel: experiments and modelling

Material3 days ago

Competitive mechanisms occurring during quenching and partitioning of three silicon variants of 0.4 wt.% carbon steels

Material4 days ago

Correlative cross-sectional characterization of nitrided, carburized and shot-peened steels: synchrotron micro-X-ray diffraction analysis of stress, microstructure and phase gradients

Material4 days ago

Influence of heavy metal oxides to the mechanical and radiation shielding properties of borate and silica glass system

Material3 days ago

Activated carbon electrode with promising specific capacitance based on potassium bromide redox additive electrolyte for supercapacitor application

Heartland3 days ago

Where To Buy CBD in Fort Worth

Material4 days ago

Electronic and magnetic properties of graphene quantum dots doped with alkali metals

News4 days ago

2:1 or 1:1 CBD to Delta-8 THC Ratio: You Decide!

Material5 days ago

Fatigue rate evaluation of a transparent polyester resin subjected to low-temperature environments

Heartland4 days ago

Is CBD isolate effective for anxiety?

Heartland4 days ago

Efficacy of CBD Edibles

Trending

A Cloud Nine Capital Entity Copyright © 2020 – All Rights Reserved Proudly Made in America