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Benefit of Tetrahydrocannabinol versus Cannabidiol for Common Palliative Care Symptoms

Objectives: To determine the relative contributions of tetrahydrocannabinol (THC) and cannabidiol (CBD) to patients’ self-ratings of efficacy for common palliative care symptoms. Design: This is an electronic record-based retrospective cohort study. Model development used logistic regression with bootstrapped confidence intervals (CIs), with standard errors clustered to account for multiple observations by each patient. Setting: This is a national Canadian patient portal. Participants: A total…

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Objectives: To determine the relative contributions of tetrahydrocannabinol (THC) and cannabidiol (CBD) to patients’ self-ratings of efficacy for common palliative care symptoms. Design: This is an electronic record-based retrospective cohort study. Model development used logistic regression with bootstrapped confidence intervals (CIs), with standard errors clustered to account for multiple observations by each patient. Setting: This is a national Canadian patient portal. Participants: A total of 2,431 patients participated. Main Outcome Measures: Self-ratings of efficacy of cannabis, defined as a three-point reduction in neuropathic pain, anorexia, anxiety symptoms, depressive symptoms, insomnia, and post-traumatic flashbacks. Results: We included 26,150 observations between October 1, 2017 and November 28, 2018. Of the six symptoms, response was associated with increased THC:CBD ratio for neuropathic pain (odds ratio [OR]: 3.58; 95% CI: 1.32-9.68; p = 0.012), insomnia (OR: 2.93; 95% CI: 1.75-4.91; p < 0.001), and depressive symptoms (OR: 1.63; 95% CI: 1.07-2.49; p = 0.022). Increased THC:CBD ratio was not associated with a greater response of post-traumatic stress disorder (PTSD)-related flashbacks (OR: 1.43; 95% CI: 0.60-3.41; p = 0.415) or anorexia (OR: 1.61; 95% CI: 0.70-3.73; p = 0.265). The response for anxiety symptoms was not significant (OR: 1.13; 95% CI: 0.77-1.64; p = 0.53), but showed an inverted U-shaped curve, with maximal benefit at a 1:1 ratio (50% THC). Conclusions: These preliminary results offer a unique view of real-world medical cannabis use and identify several areas for future research.

Keywords: cannabis; palliative care; symptom control.

Source: https://pubmed.ncbi.nlm.nih.gov/31386592/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1LgINZmdEb7hTii13TOa5DGOR2cvkVQ2sw4N7-xSaEiod6ucE1&fc=20200804221722&ff=20200813025825&v=2.11.5

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Get the calming and pain-relieving benefits of CBD with these gummies

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With the CBD market emerging into a health and wellness juggernaut over the … However, how do you know what's in that CBD product you're buying? … chronic pain and inflammation, regulating blood pressure, soothing anxiety, … Source:

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Global Cannabidiol Oil (CBD Oil) Market Data Analysis 2020-2026: Whistler, CBD American …

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Numerous dominant market players such as Whistler, CBD American Shaman, NuLeaf Naturals, Kazmira, Emblem Cannabis Oils, ENDOCA, CW Hemp/ … Source:

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Global Cannabidiol Oil (CBD Oil) Market Data Analysis 2020-2026: Whistler, CBD American …

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… ENDOCA, CW Hemp/CW Botanicals, Absolute Terps, Freedom Leaf, The Lab, Canopy Growth Corporation, Folium Biosciences, HempLife Today, … Source:

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